The average percent release of Sentil (500 mg table) after

10, 15, 20, 30, 45 and 60 minutes are:

Tablet A (Brand): 70.9, 86.61, 91.11, 97.15, 99.11,
102.09
Tablet B (Test) :
X , 67.20, 75.13, 84.42, 88.10,
99.84
Calculate the value of X when (similarity factor) is found
to be 41.99.

Solution:
The average percent release of cefuroxime axetil (500 mg table)
after 10, 15, 20, 30, 45 and 60 minutes are:
Tablet A (Brand): 70.9, 86.61, 91.11, 97.15, 99.11, 102.09
Tablet B (Test) :
X , 67.20, 75.13, 84.42, 88.10, 99.84
And (similarity factor) is found to be 41.99.
We know, Similarity factor

Here, Number of timing (n) = 6

(R10 T10) = (70.9 X)
(R15 T15) = (86.61 67.20) = 376.75
(R20 T20) = (91.11 75.13) = 255.36
(R30 T30) = (97.15 84.42) = 162.05
(R45 T45) = (99.11 88.10) = 121.22
(R60 T60) = (102.09 99.84) = 5.06

According to the condition,

50 log ([1 + 1/6{920.44 + (70.9 X)}]-0.5 x 100) = 41.99
log ([1 + 1/6{920.44 + (70.9 X)}]-0.5 x 100) = 0.84
([1 + 1/6{920.44 + (70.9 X)}]-0.5 x 100) = 6.9183
[1 + 1/6{920.44 + (70.9 X)}]-0.5 = 0.0692
[1 + 1/6{920.44 + (70.9 X)}] =
[1 + 1/6{920.44 + (70.9 X)}] = 208.83
1/6{920.44 + (70.9 X)} = 207.83
{920.44 + (70.9 X)} = 1246.98
(70.9 X) = 326.54
70.9 x = 18.07
When (+) is taken, then

When () is taken, then

70.9 x = 18.07

70.9 x = 18.07

.. x = 52.02

.. x = 88.16