How to take Diosmin? Diosmin, guidechem, 520-27-4 Diosmin is a type of plant chemical found mainly in citrus fruits.

People use diosmin to make medicine. It is a semisynthetic drug (modified hesperidin), a member of the flavonoid family. It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin. Diosmin(CAS NO: 520-27-4) is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs (venous stasis), and bleeding (hemorrhage) in the eye or gums. It is also used to treat swelling of the arms (lymphedema) following breast cancer surgery, and to protect against liver toxicity. It is often taken in combination with hesperidin, another plant chemical. Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis. This increases the venous return and reduces venous hyperpressure present in patients suffering from CVI. Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries. Furthermore, this medicine with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure. At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes. It reduces the expression of endothelial adhesion molecules (ICAM1, VCAM1), and inhibits the adhesion, migration, and activation of leukocytes at the capillary level. This leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins (PGE2, PGF2a). Diosmin is often taken in combination with hesperidin.The following doses have been studied in scientific research: By mouth: For the treatment of internal hemorrhoids: 1350 mg of diosmin plus 150 mg of hesperidin twice daily for 4 days followed by 900 mg of this medicine and 100 mg of hesperidin twice daily for 3 days. Some researchers also try 600 mg of this medicine three times daily for 4 days, followed by 300 mg twice daily for 10 days, in combination with 11 grams of psyllium daily. However, this lower diosmin dose does not seem to be as effective. For prevention of relapse internal hemorrhoids: 450 mg of this medicine plus 50 mg of hesperidin

twice daily for 3 months of therapy. For the treatment of leg wounds due to bloodflow problems (venous stasis ulcers): the combination of 900 mg of this medicine and 100 mg of hesperidin daily has been used for up to 2 months. Diosmin is safe for most people when used short-term for up to three months. It can cause some side effects such as stomach and abdominal pain, diarrhea, and headache. Do not take it for more than three months without medical supervision. Here are some Special Precautions & Warnings about Diosmin, you should be careful: Pregnancy and breast-feeding: Not enough is known about the use of diosmin during pregnancy and breast-feeding. Stay on the safe side and avoid use. Want to learn more information about Diosmin, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals.