Pharmacokinetics Equation Sheet Neuro/Psych Medications

General C = Dose/Vd LD = C x Vd CL = Vd x Kd Kd=CL/Vd (ke and kd can be used interchangeably) Cpss = Dose (S)(F) CL Tau Dose = Cpss CL Tau (S)(F) Cmax = Dose/Vd + Cmin Kd=lnCmax/Cmin t Cpssmin= Dose(S)(F) e-kdtau Vd (1 e-kdtau ) Dose = Cpssmin X Vd X (1-e-kdtau ) e-kdtau (S)(F)

Phenytoin Bioavailablity (F) = 1 Salt Factor Capsule = 0.92 Phenytoin injection = 0.92 Fosphenytoin injection = 0.92 Suspension = 1 Chewable tablet = 1

Phenytoin (continued) Vd = 0.7 L/kg Km = 4.3 mg/L Vmax = 7.4 mg/kg/day

Dose (F)(S)= Vmax X Css Km + Css -Km= MD1-MD2 . MD1 MD2 Css1 Css2 Vmax = (MD2 X S)(Km + Css2) Css2 Ctotal adj = Ctotal 0.2 X albumin + 0.1

Valproic Acid Bioavailability (F) for ER forms= 0.9 (all other forms F=1) Salt Factor = 1 Vd (adults <60 years) = 0.12 L/kg CL(children 3-16 years) = 0.018 L/hr/kg CL(adults < 60 years) = 0.009 L/hr/kg CL (geriatrics >60 year) = 0.007L/hr/kg

Phenobarbital Bioavailability = 1 Salt Factor (for Na salt) = 0.9 Vd (neonates) = 0.96 L/kg Vd (2 weeks 19 years) = 0.63 L/kg Vd (adults > 19 years) = 0.61 L/kg CL (< 1 year) = 0.0047 L/hr/kg CL ( 1-19 years) = 0.0082 L/hr/kg CL (19-65 years) = 0.0056 L/hr/kg CL (>65 years) = 0.0024 L/hr/kg

Carbamazepine Bioavailability (F) = 0.8 Salt Factor = 1 Vd = 0.8-2 L/kg recommend using 1.4 L/kg CL (monotherapy) = 0.064L/hr/kg CL (polytherapy) = 0.01 L/hr/kg

Lithium Bioavailability (F) = 1 Salt Factor = 1 Vd (children) = 0.93 L/kg Vd (adults) = 0.85 L/kg Vd (>59 years) = 0.53 L/kg CL (lithium) = 0.23 (CrCl)