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    Pathophysiology of Peptic Ulcer Disease Definition

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    Israel Soria Espero
    Peptic ulcer disease is caused by erosion of the mucosal lining of the stomach. Predisposing factors include age over 40, male gender, lifestyle factors like alcohol ingestion, and familial tendencies. Precipitating factors can be malignant tumors, gastric hyperacidity, stress, and irritating foods. Damage to the mucosa from things like alcohol, smoking, and aspirin can allow acid and pepsinogen to cause ulcers. Infection with Helicobacter pylori or an imbalance of protective factors can also lead to ulcers. Ulcers result in erosive gastritis, inflammation, decreased acid production, and mucosal ulcerations that can potentially bleed and scar.

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    Pathophysiology of Peptic Ulcer Disease Definition

    Uploaded by

    Israel Soria Espero
    102 views2 pages
    Peptic ulcer disease is caused by erosion of the mucosal lining of the stomach. Predisposing factors include age over 40, male gender, lifestyle factors like alcohol ingestion, and familial tendencies. Precipitating factors can be malignant tumors, gastric hyperacidity, stress, and irritating foods. Damage to the mucosa from things like alcohol, smoking, and aspirin can allow acid and pepsinogen to cause ulcers. Infection with Helicobacter pylori or an imbalance of protective factors can also lead to ulcers. Ulcers result in erosive gastritis, inflammation, decreased acid production, and mucosal ulcerations that can potentially bleed and scar.

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    20308136 Pathophysiolohy of Peptic Ulcer

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    Peptic ulcer disease is caused by erosion of the mucosal lining of the stomach. Predisposing factors include age over 40, male gender, lifestyle factors like alcohol ingestion, and familial tendencies. Precipitating factors can be malignant tumors, gastric hyperacidity, stress, and irritating foods. Damage to the mucosa from things like alcohol, smoking, and aspirin can allow acid and pepsinogen to cause ulcers. Infection with Helicobacter pylori or an imbalance of protective factors can also lead to ulcers. Ulcers result in erosive gastritis, inflammation, decreased acid production, and mucosal ulcerations that can potentially bleed and scar.

    Copyright:

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    Download as PDF, TXT or read online from Scribd
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    102 views2 pages

    Pathophysiology of Peptic Ulcer Disease Definition

    Uploaded by

    Israel Soria Espero
    Peptic ulcer disease is caused by erosion of the mucosal lining of the stomach. Predisposing factors include age over 40, male gender, lifestyle factors like alcohol ingestion, and familial tendencies. Precipitating factors can be malignant tumors, gastric hyperacidity, stress, and irritating foods. Damage to the mucosa from things like alcohol, smoking, and aspirin can allow acid and pepsinogen to cause ulcers. Infection with Helicobacter pylori or an imbalance of protective factors can also lead to ulcers. Ulcers result in erosive gastritis, inflammation, decreased acid production, and mucosal ulcerations that can potentially bleed and scar.

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    PATHOPHYSIOLOGY OF PEPTIC ULCER DISEASE Definition: Peptic ulcer disease is an excavation (hollowed-out area) that forms in the mucosal

    wall of the stomach. Erosion of a circumscribed area of mucous membrane is the cause.

    Predisposing Factors Age (40- 0) #ender &ifest%le (Alcohol ingestion) (amilial tendenc%

    Precipitating Factors ! "alignant tumors ! #astric $%peracidit% ! 'tress ! )rritating (oods

    *amage to mucosa with alcohol abuse+ smo,ing+ use of aspirin - .'A)*/s

    Acid - pepsinogen release with chronic vagal response to increased stress

    )nfection with $elicobacter P%lori

    *amaged mucosal barrier

    )mbalance of aggressive defensive factor

    &ow function of mucosal cells0 low 1ualit% of mucous0 less of tight 2unction between cells )nfection gives increased gastrin decreased somatostatin production

    Erosive gastritis3 inflammation !! decreased acid and intrinsic factor "ucosal ulcerations+ possible bleeding and scarring

    A damage mucosa could not secrete enough mucus to act as a barrier against gastric acid. 'evere ulcerations3 Signs and symptoms: Epigastric pain $ematemesis *%spepsia p%rosis

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