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MALE REPRODUCTION

By Khairun Nisa

Physiology of Male Reproduction


Regulation of Reproductive Hormone secretion in Males: 1. Gn-RH from hypothalamus stimulates the secretion of LH and FSH from anterior pituitary 2. LH stimulates the interstitial cells of the testes to secrete testosterone, and FSH binds to the sertoli cells of the seminiferous tubules and stimulates spermatogenesis 3. Testosterone has a stimulatory effect on the sex organs and secondary sex characteristics, as well as on the sertoli cells 4. Testosterone has a negative feed back effect on the hypothalamus and pituitary gland to reduce LH and FSH secretion 5. Inhibin has a negative feedback effects on FSH secretion.

Major Reproductive Hormones in Males


Hormone Source GnRH Target Tissue Respones
Stimulates secretion of LH and FSH Stimulates Interstitial synthesis and cells of the secretion of testosterone testes Seminiferous Supports spermatogenesis tubules and inhibin (sertoli cells) secretion

Hypothalamus Anterior pituitary Anterior pituitary Anterior pituitary

LH

FSH

Major Reproductive Hormones in Males


Hormone Source Target Tissue Respones
Development and maintenance of reproductive organs Stimulates secretion of LH and FSH Stimulates synthesis and secretion of testosterone Supports

Testostero Interstitial cells Testes, body ne of the testes tissues

Inhibin

Sertoli-sell

Anterior pituitary

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