PROBLEM SET 2 1.

The irreversible reaction has been studied kinetically, and the rate of formation of product has been found to be well correlated by the following rate equation:

What reaction mechanism is suggested by this rate expression if the chemistry of the reaction suggests that the intermediate consists of an association of reactant molecules and that a chain reaction does not occur? 2. Here, a reactant, called the substrate, is converted to product by the action of an enzyme, a high molecular weight (mw > 10 000) protein-like substance. An enzyme is highly specific, catalyzing one particular reaction, or one group of reactions. Thus,

Many of these reactions exhibit the following behavior: 1. A rate proportional to the concentration of enzyme introduced into the mixture [E,]. 2. At low reactant concentration the rate is proportional to the reactant concentration, [A]. 3. At high reactant concentration the rate levels off and becomes independent of reactant concentration. Propose a mechanism to account for this behavior. 3. 4. 5. 6. 7. 8. 9. 10. Problem 2.2 Problem 2.4 Problem 2.6 Problem 2.7 Problem 2.11 Problem 2.13 Problem 2.19 The following mechanism represents the reaction A P.

( ) ( ) ( )

The rate of disappearance of A is proportional to its concentration. a. Show that the presented mechanism represents the given reaction. b. Express k in terms of k1, k2, k3, and [M].