Scribd Logo
Upload

Welcome to Scribd!

  • Nubain Mechanism of Action

    Uploaded by

    Patricia Marie Buenafe
    269 views1 page
    Nubain is a narcotic agonist-analgesic that acts on kappa opiate receptors and partially antagonizes mu opiate receptors, producing analgesia, respiratory depression, and sedation. It is administered intramuscularly or intravenously, with effects beginning within 15 minutes via IM or 2-3 minutes via IV and lasting 3-6 hours. Nubain is metabolized in the liver and eliminated from the body within 5 hours mainly through urine and feces. It is used to treat pain at doses up to 20 mg for non-opioid tolerant patients and 160 mg per day, and can also be used to supplement anesthesia.

    Original Description:

    Nubain Drug study

    Original Title

    Nubain

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Nubain is a narcotic agonist-analgesic that acts on kappa opiate receptors and partially antagonizes mu opiate receptors, producing analgesia, respiratory depression, and sedation. It is administered intramuscularly or intravenously, with effects beginning within 15 minutes via IM or 2-3 minutes via IV and lasting 3-6 hours. Nubain is metabolized in the liver and eliminated from the body within 5 hours mainly through urine and feces. It is used to treat pain at doses up to 20 mg for non-opioid tolerant patients and 160 mg per day, and can also be used to supplement anesthesia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    269 views1 page

    Nubain Mechanism of Action

    Uploaded by

    Patricia Marie Buenafe
    Nubain is a narcotic agonist-analgesic that acts on kappa opiate receptors and partially antagonizes mu opiate receptors, producing analgesia, respiratory depression, and sedation. It is administered intramuscularly or intravenously, with effects beginning within 15 minutes via IM or 2-3 minutes via IV and lasting 3-6 hours. Nubain is metabolized in the liver and eliminated from the body within 5 hours mainly through urine and feces. It is used to treat pain at doses up to 20 mg for non-opioid tolerant patients and 160 mg per day, and can also be used to supplement anesthesia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    of 1

    NUBAIN Mechanism of Action

    Narcotic agonist-analgesic of kappa opiate receptors and partial antagonist of mu opiate receptors; inhibits ascending pain pathways, thus altering response to pain; produces analgesia, respiratory depression, and sedation

    Absorption
    Onset: IM, 15 min; IV, 2-3 min Duration: 3-6 hr Peak plasma time: IM, 30 min; IV, 1-3 min

    Distribution
    Protein bound: Not significant

    Metabolism
    Metabolized in liver

    Elimination
    Half-life: 5 hr Excretion: Urine, feces

    Pain Non-opioid-tolerant patients: 10-20 mg/70kg IV/IM/SC q3-6hr PRN; individual dose not to exceed 20 mg Opioid-dependent patients: Administer dose, and observe for withdrawal signs
    Not to exceed 160 mg/day

    Anesthesia Supplement 0.3-3 mg/kg IV over 10-15 minutes, then 0.25-0.5 mg/kg PRN Opioid-Induced Pruritus (Off-label) Prevention and treatment Dosing Modifications Renal impairment: Caution; dose reduction may be necessary; monitor
    Hepatic impairment: Caution; dose reduction may be necessary; monitor

    You might also like