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Pathophysiology of Erythroblastosis Fetalis RH Isoimmunization
Pathophysiology of Erythroblastosis Fetalis RH Isoimmunization
Pathophysiology of Erythroblastosis Fetalis RH Isoimmunization
Motor Dysfunction Shift to Anaerobic Metabolism Deposition of Heme in the Basal Ganglia Lactic Acidosis
KERNICTERUS Formation of antiRh antibody in the mothers serum Anti-Rh antibody may be IgG (the smallest antibody) THIS CAN CROSS THE PLACENTA AND MAY ENTER THE FETAL CIRCULATION! Anti-Rh antibody may be IgM (the largest antibody) and this cant cross the placenta (will not be transferred from mother to fetus) unless there is fetal-maternal transfusion
FOR THE NEXT PREGNANCY, AGAIN WITH Rh(+) FETUS Anti-Rh antibody, formed by the mother, enters the fetal circulation and binds with Rh antigens on the surface of fetal erythrocytes Jaundice