1

Sulfanilamide

: Sulfanilamide

,
,




,

2 2 30
,

Sodium
Carboxymethyl Cellulose 1.5%

: Sulfanilamide , ,
, , ,

(Powders)

10 0.1

10,000 - 0.1
(m) (1
= 0.001
)

(comminution)

(Dusting
Powders)

,talc

100

bentonite,

kaolin,

magnesium carbonate

starch

1.

talc

stearate
stearate

aluminum

kaoin

zinc

magnesium

stearate

starch

160

1
talc

Clostridium tetani

2.

boric acid
zinc
stearate powder

3.

geometric dilution

100

sifter-top cans

(widemouth bottles with a

powder puff)

1.

1
1
100-120
2
2.

starch
lactose,

magnesium

carbonate

(alcoholic

preparations)

(fluidextract)

(double wrapping)

inert absorbent powder

4.

3.

(essential oils)

3
4.1 Eutectic Mixtures

eutectic

2 2

hydrous

eutectic

absorbent

4.2

4.3

sodium

(Hygroscopic Drugs and

alums

hygroscopic

phosphate, sodium sulfate,

ammonium

alum

potassium alum
ferrous sulfate

anhydrous
forms

Deliquescent
potassium

Substances)

thiocyanate

potassium acetate

divided dosage
forms

absorbent

(oxidizing agents)

5.

potassium
potassium

chlorate,

permanganate,

sodium peroxide silver

nitrate reducing
agents

charcoal,
starch, sugar, tannic acid,

sulfur sulfides

Sulfanilamide

Pharmaceutical

Higuchi
Analysis

page 143

1 : 1-4

(g)
SulfanilamideTannin Talcum
1
99.0
0.4
0.3
2
99.3
0.4
0.2
3
99.3
0.4
0.1.
4
99.3
0.4
-

SLS
0.1
0.2
0.3

Sodium

Sulfanilamide tannin

laurylsulfate (SLS)

wetting

agent

wetting agent
solution

damp
mass

16 mesh
50 C

SLS
Tween 80

wetting

agent

4 30


2

5 18

10

(g)

Sulfanilamide
Tannin Talcum
5
water
99.30
0.40
0.30
6
water
99.30
0.40
0.20
7
water
99.30
0.40
0.10
8
water
99.30
0.40
9
water
99.30
0.40
0.20
10
water
99.30
0.40
0.10
11
water
99.30
0.40
12 water: EtOH
*
99.30
0.40
0.30
13 water: EtOH
*
99.30
0.40
0.20
14 water: EtOH
*
99.30
0.40
0.10
15 water: EtOH
*
99.30
0.40
16 water: EtOH
*
99.30
0.40
0.20
17 water: EtOH
*
99.30
0.40
0.10
18 water: EtOH
*
99.30
0.40
-

* water : EtOH

= 1:1

SLS Tween
80
0.10
0.20
0.30
0.10
0.20
0.30
0.10
0.20
0.30
0.10
0.20
0.30

11

50 C .

3 7
8

3 : 19-34

(g)

Sulfanilamide
Tannin Talcum
19
water
99.30
0.40
0.10
20
water
99.30
0.40
0.10
21
water
99.30
0.40
0.10
22
water
99.30
0.40
0.10
23
water
99.30
0.40
0.10
24
water
99.30
0.40
0.10
25
water
99.30
0.40
0.10
26
water
99.30
0.40
0.10
27
water
99.30
0.40
28
water
99.30
0.40
29
water
99.30
0.40
30
water
99.30
0.40
31
water
99.30
0.40
32
water
99.30
0.40
33
water
99.30
0.40
34
water
99.30
0.40
-

SLS
0.20
0.20
0.20
0.20
0.20
0.20
0.20
0.20
0.30
0.30
0.30
0.30
0.30
0.30
0.30
0.30

(

)
1.00
1.50
2.00
3.00
3.50
4.00
4.50
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
4.50

12

Sodium

damp mass

Carboxymethyl

Cellulose

(NaCMC) , Xanthan gum ,

Hydroxypropyl

Methyl

Cellulose (HPMC)
Polyvinyl pyrrolidone (PVP)

K90

3%

4 : 35 46

50 C
2 30

13

(g)

Sulfanilamide
Tannin SLS (Polymer
)
35
water
98.80
0.40
0.30
(NaCMC
) 0.50
36
water
98.30
0.40
0.30
(NaCMC
) 1.00
37
water
97.80
0.40
0.30
(NaCMC
) 1.50
38
water
98.80
0.40
0.30 (Xanthan )gum
0.50
39
water
98.30
0.40
0.30 (Xanthan )gum
1.00
40
water
97.80
0.40
0.30 (Xanthan )gum
1.50
41
water
98.80
0.40
0.30
(HPMC
) 0.50
42
water
98.30
0.40
0.30
(HPMC
) 1.00
43
water
97.80
0.40
0.30
(HPMC
) 1.50
44
water
98.80
0.40
0.30
(PVP 90
K) 0.50
45
water
98.30
0.40
0.30
(PVP 90
K) 1.00
46
water
97.80
0.40
0.30
(PVP 90
K) 1.50

14

29 30

ethanol

7 8

NaCMC



1.5 %

15

Talcum

Sulfanilamide

SLS

NaCMC 1.5%

wetting

agent SLS

SLS 0.3%

16

1. Ansel

H.C.(1978).

Introduction

to

Pharmaceutical

Dosage

forms. 2 nd Ed. 169215.

2. British

Pharmacopeia

1998 , 1475.

3. Meark index , 1989 , p

407.

4. Pharmaceutical

excipient , p. 45-48 ,
138-40 , 225-27 , 35961 , 519-21.

5. Parrot EL. In Lachman L

, et al. The theory and

practice

Pharmacy

of

Industrial
3

rd

ed.

Philadephia:

Lea

Febiger , 1986 , p32.

&

6. Hwaing ou lin , Physical

properties

of

Sulfanilamide I , Journal
of

Pharmmaceutical

Sciences , 1974 , 145146.

7. Pilar

bustanmante

Chameleonic
sulanilamide

effect

of

and

sulamethazine in solvent
Mixtures.

Solubility

curves with teo maxima ,

pharmaceutical Society of
Japan 1994 ,
1133.

1129-

17