Granulomatous arteritis of aorta and major branches, esp.

extracranial branches of carotid artery

Giant-Cell Arteritis (a.k.a temporal arteritis)

Small vessel vasculitis with palpable purpura Idiopathic, but may be:

Drug-induced Due to viral infection CT disease (SLE, RA)

Elderly Fever Bi-temporal headache Large Vessel Vasculitides Jaw and tongue claudication ESR and CRP highly elevated Cause of sudden blindness Skip lesions Biopsy of temporal artery Manifestations Leukocytoclastic Vasculitis

Immunouorescence: igA deposition HSP A systemic form of leukocystic vasculitis

Often follows URTI Acute onset Palpable purpura Abdominal pain and bleeding Arthritis Paediatric milder than adult Nephritis

Stenoses

Aorta and major branches

Takayasu's Arteritis Small Vessel Vasculitis Cryoglobulinaemia

Insidious onset

Raynaud's phenomenon Purpura Arthralgia

Young women (<40 years)

Esp. S and SE Asia

Vasculitis
Limbs (arm pain) CNS (stroke) Malaise Systemic in. Ischaemia Sx Disease associations Glomerulonephritis (mesangiocapillary) B-cell lymphoproliferative disease Autoimmune diseases Hepatitis C infection (acuired form of cryglobulinaemia) Kawasaki's Disease Other Other viral infections Systemic Necrotising Vasculitis Extremities w/ erythema Small-to-Medium Vessel Vasculitis / ANCA-Associated Vasculitides Wegener's Granulomatosis Churg-Strauss Syndrome Respiratory and Renal Goodpasture's Syndrome Small vessels Medium vessels, no small vessel involvement ANCA-negative Ass. with Hep B infection Usually pANCA, MPO specic Skin and organ involvement Microscopic polyangiitis (MPA) Skin and Nerves Eosinophilia Prodrome of atopy Polyarteritis nodosa Acute ischaemic events + amputations Smoking 40-50 year old men Associated with 70% are pANCA+, MPO-specic Almost all have renal involvement No eosinophilia or granuloma Respiratory and Renal cANCA +, PR3 specic (usually) Polymorphous rash A!ects limbs predominantly Cervical lymphadenopathy Inammatory thrombus Other Buerger's Disease Lymphomas

Largely paediatric

Strawberry tongue

Coronary arteritis Myocarditis Pericarditis

Complications