AST (SGOT) thng c tm thy trong cc m bao gm gan, tim, c, thn, no v c pht tn vo mu khi bt k mt trong cc m trn b tn thng.

ALT (SGPT) thng c tm thy ch yu gan v c pht tn vo mu khi c tn thng gan. Do , ALT l mt ch s th hin c th v tnh trng gan. Gan b tn thng dn n s gia tng nng ALT v AST. Tuy nhin, ALT v AST tng khng ng ngha vi vic c vn v gan. ALT v AST khng phn nh chc nng ca gan. Ngay c khi AST v ALT tng cao, gan c th hot ng bnh thng.

ALT v AST thng c s dng pht hin tn thng gan. N thng c ch nh kt hp vi cc xt nghim khc kim tra chc nng gan hoc gip chn on bnh gan.

i khi t l AST/ALT c th c s dng phn bit gia cc nguyn nhn khc nhau gy ra tn thng gan.
ALT v AST thng c s dng theo di din tin iu tr ca ngi c bnh gan hoc chn on.

Bc s thng ch nh xt nghim ALT v AST nh gi mt ngi c cc triu chng ca mt ri lon chc nng gan. Mt s nhng triu chng ny bao gm:

* Sc khe yu, mt mi * Mt cm gic ngon ming * Bun nn, nn * Bng sng hoc au * Vng da *Nc tiu m mu, phn c mu nht *Nga

ALT v AST cng c th c ch nh mt mnh hoc phi hp vi cc xt nghim khc, nhng ngi c nguy c gia tng bnh gan. Mt s v d bao gm:

* Ngi c tin s tip xc vi virus vim gan * Nhng ngi nghin ru nng * C nhn c gia nh c tin s bnh gan * Ngi dng thuc m thuc c th lm ri lon chc nng gan * Ngi tha cn, hoc c bnh tiu ng
nhng ngi c triu chng nh, chng hn nh mt mi hoc st cn, ALT v AST c th c th nghim chc chn rng h khng c bnh gan mn tnh.

Bnh thng: ALT > AST AST/ALT <1 AST/ALT >1: x gan, VG ru, tn thng gan do thiu mu cc b 92%, do 1 s thuc. AST/ALT <1: VG do virus, gan nhim m khng do ru v cac1nghuyen6 nhn khc. Tim hoc tim thuc vo cc m c bp, hoc tp th dc nng, c th lm tng mc ALT va AST. Nhiu loi thuc c th lm tng ALT v AST bng cch gy tn thng gan, mt t l rt nh khi bnh nhn dng thuc. n qu nhiu thc n nhanh cng c th gy tng nh ALT v AST v n c th gy tn thng gan, ALT va AST thng s tr li bnh thng mt khi ch n ung bnh thng c lp li.

Gii hn bnh thng: Nam 30U/L, n 19U/L (AASLD 2009) ngi bnh thng, nng ca ALT v AST trong mu thp. Mc ALT v AST cao ( >10 ln) thng l do VG cp tnh, do b nhim virus. AST, ALT > 1000 U/L: tn thng gan do thiu mu cc b, VG cp do thuc, c t v virus (tr C) ALT v AST tng <10 ln trong VG mn tnh (thng <300 U/L). Tuy nhin, trong t kch pht s tng cao nh VG cp. Cc nguyn nhn khc lm ALT v AST tng va phi gm cc nguyn nhn tc nghn ng mt, x gan (thng l hu qu ca vim gan mn tnh hoc tc nghn ng mt), v c khi u trong gan. AST v ALT cng c th tng ln trong cn au tim v chn thng c, mc AST tng nhiu hn l ALT