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  • RheOlogy of Bio Process Fluids

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    Sagarika Ghosh
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    The document discusses the rheology of fermentation broths and how it is influenced by various parameters throughout a fermentation process. Key factors that determine broth rheology include biomass concentration, morphology, growth rate, and extracellular components. Correlations have been developed to describe viscosity as a function of biomass concentration alone, but these are limited as active biomass also impacts system performance. Models like the Casson plastic model and power law model have also been used to characterize rheology, but no simple relationships exist and rheological parameters vary with specific growth rate and other conditions.

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    Rheology , BPT

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    The document discusses the rheology of fermentation broths and how it is influenced by various parameters throughout a fermentation process. Key factors that determine broth rheology include biomass concentration, morphology, growth rate, and extracellular components. Correlations have been developed to describe viscosity as a function of biomass concentration alone, but these are limited as active biomass also impacts system performance. Models like the Casson plastic model and power law model have also been used to characterize rheology, but no simple relationships exist and rheological parameters vary with specific growth rate and other conditions.

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    38 views3 pages

    RheOlogy of Bio Process Fluids

    Uploaded by

    Sagarika Ghosh
    The document discusses the rheology of fermentation broths and how it is influenced by various parameters throughout a fermentation process. Key factors that determine broth rheology include biomass concentration, morphology, growth rate, and extracellular components. Correlations have been developed to describe viscosity as a function of biomass concentration alone, but these are limited as active biomass also impacts system performance. Models like the Casson plastic model and power law model have also been used to characterize rheology, but no simple relationships exist and rheological parameters vary with specific growth rate and other conditions.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    of 3

    Rheology of Bioprocess Fluids with particular reference to fermentation broths.

    References Doran, Chapter 7 Blanch and Clark, Chapter 5 Atkinson and Mavituna, Chapter !lsvik, ". and #ristiansen, B., $%heolo&' of (ilamentous (ermentations$, Biotechnol. Adv., ), *+, - ,,./. Inter-relations between viscosity and broth processing
    Medium

    Cell 3rowth

    2roduct (ormation

    Cell Morpholo&'

    4iscosit'

    Broth 5andlin& D62

    Bioreactor Conditions

    5eat 8ransfer

    Mi1in& %e7uirments

    Mass 8ransfer

    Rheology of Fermentation Fluids Bioreactor performance influenced b' broth rheolo&', which is determined b'0 biomass concentration morpholo&' biomass &rowth rate e1tracellular components

    As these parameters t'picall' ver' throu&hout the course of a fermentation, so too will the rheolo&'.

    correlations which describe viscosit' as a function of biomass concentration onl' are of limited value pol'mer solutions, paper pulp suspensions often used to simulate flow behaviour of fermentation broths, but the' do not include effects of active biomass on s'stem performance

    Correlations for broth viscosity Vand equation for a suspension of spheres -volume fraction / in a 9ewtonian li7uid of viscosit' :0

    = L ( + ).5 + 7.)5 ) )
    :imited applicabilit'; valid for 'east<spore suspensions = . vol> solids. dependenc' of on biomass &enerall' stron&er than predicted b' 4and "7uation

    Correlations for mycelial systems based on biomass concentration uthors Correlation 8akahashi and ?amada - ,@A/ . Deindorfer and 3aden - ,55/ ' ).+*).5 6olomons and Beston - ,@ / ).@5 -cell dr' wei&ht conc./, -shear stress/, ' -'ield stress/ Correlations for !ower-"aw Broths #ystem A. ni&er 2. chr'so&enum 6. levoris -Allen and %obinson, ,,A/ but %heolo&ical parameters -k, n, ' / also influenced b' specific &rowth rate, D!, osmotic pressure of medium. Cnsert pa&esD -!lsvik and #ristiansen/ Correlation k +.+ k ).5 k A.7

    Influence of #ystem $orphology e.&. 2enicillium, Asper&illus, 6treptom'ces broths

    Casson !lastic $odel

    -metE et al., ,7,/ #p :h&uA.@ ' :eA.F ).5 Bhere :e is the h'phal len&th, :&hu is the h'phal &rowth unit -total h'phal len&th<no. of tips/ Correlation found to be applicable for batch e1periments, but not for continuous -possibl' due to differences in cell fle1ibilit'/ !ower law $odel

    (atile - ,F5/ # A.+ dpA.) n *A.A@ dp*A.AF Bhere is the biomass concentration -dr' wei&ht/ and dp is the a&&re&ate diameter (re7uentl', as , # , n , but no simple relationship e1ists between solids concentration and rheolo&'.

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