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  • How Can We Use It (CPK) Clinically??: The CPK Isoenzyme Test

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    Nourhan Jamal
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    The CPK isoenzyme test measures different forms of creatine phosphokinase (CPK) in the blood to help determine the source of damaged tissue when total CPK levels are elevated. CPK-B is mostly found in the brain and lungs, so increased CPK-B levels may indicate brain or lung injuries. CPK-MB levels rise within 1-6 hours after a myocardial infarction and help diagnose heart attacks. Increased CPK-MB may also be seen after heart injuries or procedures. CPK-MM is found in skeletal muscle, so higher levels could be due to muscle damage from injuries, drugs, immobility, or strenuous exercise. The test helps doctors diagnose conditions affecting the

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    biochem of isoenzymes

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    Benefits of Cpk

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    The CPK isoenzyme test measures different forms of creatine phosphokinase (CPK) in the blood to help determine the source of damaged tissue when total CPK levels are elevated. CPK-B is mostly found in the brain and lungs, so increased CPK-B levels may indicate brain or lung injuries. CPK-MB levels rise within 1-6 hours after a myocardial infarction and help diagnose heart attacks. Increased CPK-MB may also be seen after heart injuries or procedures. CPK-MM is found in skeletal muscle, so higher levels could be due to muscle damage from injuries, drugs, immobility, or strenuous exercise. The test helps doctors diagnose conditions affecting the

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    24 views5 pages

    How Can We Use It (CPK) Clinically??: The CPK Isoenzyme Test

    Uploaded by

    Nourhan Jamal
    The CPK isoenzyme test measures different forms of creatine phosphokinase (CPK) in the blood to help determine the source of damaged tissue when total CPK levels are elevated. CPK-B is mostly found in the brain and lungs, so increased CPK-B levels may indicate brain or lung injuries. CPK-MB levels rise within 1-6 hours after a myocardial infarction and help diagnose heart attacks. Increased CPK-MB may also be seen after heart injuries or procedures. CPK-MM is found in skeletal muscle, so higher levels could be due to muscle damage from injuries, drugs, immobility, or strenuous exercise. The test helps doctors diagnose conditions affecting the

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as RTF, PDF, TXT or read online from Scribd
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    Download as rtf, pdf, or txt
    of 5

    How can we use it (CPK) clinically??

    Isoenzymes are considered as a clinical marker - it is used in diagnosis of diseases concerning the cardiac and skeletal muscles, as well as neurological disorders

    !he CPK isoenzyme test"


    !he CPK isoenzymes test measures the different forms of creatine #hos#hokinase (CPK) in the $lood

    How is the test #erformed?

    %hy the test is #erformed?


    !his test is done if a CPK test re&eals that your total CPK le&el is ele&ated CPK isoenzyme testing can hel# #in#oint the e'act source of the damaged tissue %hen the total CPK le&el is &ery high, it usually means there has $een in(ury or stress to the heart, the $rain, or muscle tissue )etermining which s#ecific form of CPK is high hel#s doctors determine which tissue has $een damaged *************************************** ***************************************

    %hat results can $e seen?


    +Higher-than-normal CPK-, le&els"
    -ecause CPK-, is found mostly in the $rain and lungs, in(ury to either of these areas can increase CPK-, le&els Increased CPK-, le&els may $e due to"

    -rain cancer -rain in(ury (due to in(ury, stroke, or $leeding in the $rain) Pulmonary infarction .eizure

    *************************************** *************************************** Higher-than-normal CPK-/ le&els" CPK-/ le&els rise 0 - 1 hours after a recent myocardial infarction If there is no further heart muscle damage, the le&el #eaks at ,/ /2 hours and returns to normal ,/ - 23 hours after tissue death Increased CPK-/ le&els may also $e due to" 1. 4lectrical in(uries 2. Heart defi$rillation (#ur#oseful shocking of the heart $y medical #ersonnel) 3. Heart in(ury (for instance, from a car accident) 4. Inflammation of the heart muscle usually

    5.

    due to a &irus 5#en heart surgery CPK-/ le&els do 65! usually rise with chest #ain caused $y angina, #ulmonary em$olism ($lood clot in the lung), or congesti&e heart failure
    !hese are usually a sign of muscle in(ury or muscle stress and may $e due to"

    Higher-than-normal CPK-0 le&els"


    Crush in(uries 7uscle damage due to drugs or $eing immo$ile for a long time 7uscular dystro#hy 7yositis (skeletal muscle inflammation) 8ecei&ing many intramuscular in(ections 4lectromyogra#hy 8ecent seizures 8ecent surgery .trenuous e'ercise

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