BI324 OConnor Linkage Practice (1) Jhbjsujdu

You might also like

Download as odt, pdf, or txt
Download as odt, pdf, or txt
You are on page 1of 1

Tackling Linkage Problems

A man is heterozygous for two genes for two genes TS (the gene for the disease tuberous sclerosis) and the A ! blood grou" gene# The alleles are denoted as follows#$ TS ts% A ! If the sperm of man are analysed and the following results are obtained:
Number of sperm that are TS, A Number of sperm that are ts, a Number of sperm that are ts, A Number of sperm that are TS, a 500 500 100 100

1. hat !an you tell about the two genes" #. The A$% gene is on human !hromosome &, where is the TS gene" '. In whi!h arrangement were the genes on his !hromosomes (or to put it another way, whi!h are the parental types") *. hi!h are the re!ombinant types" 5. hat is the distan!e between A$% and TS a!!ording to this data" +. If the data were are follows than now would your abo,e answers differ"
Number of sperm that are TS, A Number of sperm that are ts, a Number of sperm that are ts, A Number of sperm that are TS, a 100 100 500 500

The s"erm from a man who is heterozygous for genes &% ' and ( were analysed and the following results were obtained#
Number of sperm that are -.I Number of sperm that are ghi Number of sperm that are g.i Number of sperm that are -hI Number of sperm that are -.i Number of sperm that are ghI Number of sperm that are g.I Number of sperm that are -hi *01 *01 1 1 +& +& #& #& Total

1000

1. In whi!h arrangement were the genes on his !hromosomes (or to put it another way, whi!h are the parental types") #. hi!h are the double re!ombinant types i.e. those resulting from # !rosso,ers" '. hi!h are the single re!ombinant types i.e. those resulting from 1 !rosso,er" *. hi!h gene is in the middle" ($egin to draw the map) 5. The formula: #&/#&/1/1 01001 2easures the distan!e between whi!h # genes" 1000 +. The formula: 3&/3&/1/1 01001 2easures the distan!e between whi!h # genes" 1000 3. If the results were as follows, how would your answers to the abo,e differ"
Number of sperm that are -.I Number of sperm that are ghi Number of sperm that are g.i Number of sperm that are -hI Number of sperm that are -.i Number of sperm that are ghI Number of sperm that are g.I Number of sperm that are -hi #& #& +& +& 1 1 *01 *01 Total

1000

(f you can do these "roblems then you ha)e mastered the basics of genetic ma""ing*

You might also like