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    Psychoneuroimmunology (PNI) studies the relationships between the central nervous system, endocrine system, and immune system due to behavior/stress and their effects on health. It explains how psychological factors affect the immune system and vice versa through the hypothalamic-pituitary-adrenal (HPA) axis and cytokines. Stress increases pro-inflammatory cytokine production, which regulates immune cell production and influences the HPA axis and sympathetic-nervous system. The central nervous, immune, and endocrine systems mutually influence each other in a complex relationship.

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    1 PSYCHONEUROIMMUNOLOGY

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    Psychoneuroimmunology (PNI) studies the relationships between the central nervous system, endocrine system, and immune system due to behavior/stress and their effects on health. It explains how psychological factors affect the immune system and vice versa through the hypothalamic-pituitary-adrenal (HPA) axis and cytokines. Stress increases pro-inflammatory cytokine production, which regulates immune cell production and influences the HPA axis and sympathetic-nervous system. The central nervous, immune, and endocrine systems mutually influence each other in a complex relationship.

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    247 views7 pages

    1 Psychoneuroimmunology

    Uploaded by

    arga_potter6754
    Psychoneuroimmunology (PNI) studies the relationships between the central nervous system, endocrine system, and immune system due to behavior/stress and their effects on health. It explains how psychological factors affect the immune system and vice versa through the hypothalamic-pituitary-adrenal (HPA) axis and cytokines. Stress increases pro-inflammatory cytokine production, which regulates immune cell production and influences the HPA axis and sympathetic-nervous system. The central nervous, immune, and endocrine systems mutually influence each other in a complex relationship.

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    of 7

    PSYCHONEUROIMMUNOLOGY Prof.

    Fanani

    Psychoneuroimmunology (PNI) adalah ilmu yang mempelajari hubungan antara sistem saraf pusat, sistem endokrin, dan sistem imun akibat perilaku/stress dan pengaruhnya terhadap kesehatan. BASIC CONCEPT STRESS

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    How psychological factors affect our immune system & viceversa: Sistem saraf mempengaruhi sistem endokrin melalui kelenjar hipofisis yang mengontrol sekresi hormon. Lalu, sistem endokrin melalui jalur HPA axis akan memodulasi sitem imun Sistem saraf otonom juga berpengaruh langsung terhadap sistem imun melalui gland. tymus, limpa, dan sum-sum tulang.

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    Pada kondisi stres, produksi pro-inflamatory cytokine meningkat. Cytokines merupakan salah satu komponen yang mengatur produksi sel imun dan juga mempengaruhi SSP dan HPA axis. Cytokines also drive our physiological illness response, affecting our mood, fever, eating, and sleeping patterns, along with other associated behaviours.

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    Thus, yes, its complex! : Sistem saraf pusat, sistem imun, dan sistem endokrin saling mempengaruhi satu sama lain.

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    Simplified scheme of integrated regulation of the hypothalamicpituitary-immune axis. Black arrows: release of; green arrows: stimulation or enhancement of expression or release; red arrows: inhibition (bisa dilihat di slide bila FC.nya hitam putih).

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    How

    Might

    Information

    From

    the

    Field

    of

    Psychoneuroimmunology Influence Your Clinical Practice? Ask about life stressors (short term and chronic), impact on functioning Ask about how a pt is coping, social supports. Does it help? Recognize that test results during chronically stressful times could be unreliable (repeat testing?) Recognize that vaccinations may be less protective during stressful times (consider other precautions) Recognize that wound healing may be influenced by stress Recognize that immune functions may be affected by the use of drugs that influence the ANS or glucocorticoids (e.g., bblockers). Ask about therapy and make recommendations and/or referrals as needed (know what is available in the community). recognize the limitations in knowledge when patients ask about whether a given therapy (visualization, etc) can improve their immune system.

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