Fibroid

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UTERINE FIBROID

A uterine fibroid (also uterine leiomyoma, myoma, fibromyoma, leiofibromyoma,

fibroleiomyoma, and fibroma) is a benign tumour that originates from the myometrium and the accompanying connective tissue of the uterus.

PATHOLOGY
Leiomyomas grossly appear as round, well

circumscribed (but not encapsulated), solid nodules


that are white or tan, and show whorled appearance

on histological section
Microscopically, tumor cells resemble normal cells (elongated, spindle-shaped, with a cigar-shaped nucleus) and form bundles with different directions (whorled).

LOCATION
Intramural fibroids Subserosal fibroids Submucosal fibroids Cervical fibroids

SYMPTOMS
Menstrual disturbance Pressure symptoms Pain: Sub- fertility Obstetric complications Abdominal discomfort or bloating Back ache

PREDISPOSING FACTORS
Nulliparity Obesity Family history African racial origin

TYPES OF FIBROID DEGENERATION


Atrophy Red degeneration Hyaline degeneration Calcareous degeneration

Sacromatous changes
Calcification of fibroid

DIAGNOSIS
Bimanual examination gynaecologic USG Magnetic resonance imaging hysterosalpingography

TREATMENT
Asymptomatic treatment. periodically most cases of fibroids are managed by "watchful waiting" fibroids Patients do are not require

reevaluated

Medical therapy
Gonadotrophin releasing hormone analogues Leuprolide (lupron) 3.75 mg IM

progesterone antagonists

Exogenous progestins
Medroxyprogesterone (PROVERA) acetate

5 to 10 mg po once/day
Megestrol( Megace) acetate 10 to 20 mg po

once/day given 10 to 14 days each menstrual


cycle can limit heavy bleeding

Depot medroxyprogesterone (provera) acetate


150 mg IM q 3 mo

Antiprogestins Selective estrogen receptor modulators Danazol, an androgenic agonist NSAIDs

SURGERY
myomectomy

hysterosccopic myomectomy
laparoscopic myomectomy laprotomic myomectomy Robotic Myomectomy with da Vinci Surgical Robot

UTERINE FIBROID EMBOLIZATION MYOMA COAGULATION RADIOFREQUENCY ABLATION HIGH INTENSITY FOCUSED ULTRASOUND

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