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    HaritsaBudiman
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    The document discusses the pathways involved in inflammation and pain sensation. It mentions that trauma or injury can stimulate phospholipase A2, which acts on phospholipids to produce prostaglandins and leukotrienes via the lipoxygenase and cyclooxygenase pathways. These inflammatory mediators then activate immune cells, cause blood vessel changes, and stimulate nociceptors to produce the sensation of pain.

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    The document discusses the pathways involved in inflammation and pain sensation. It mentions that trauma or injury can stimulate phospholipase A2, which acts on phospholipids to produce prostaglandins and leukotrienes via the lipoxygenase and cyclooxygenase pathways. These inflammatory mediators then activate immune cells, cause blood vessel changes, and stimulate nociceptors to produce the sensation of pain.

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    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    15 views3 pages

    Presentation 3

    Uploaded by

    HaritsaBudiman
    The document discusses the pathways involved in inflammation and pain sensation. It mentions that trauma or injury can stimulate phospholipase A2, which acts on phospholipids to produce prostaglandins and leukotrienes via the lipoxygenase and cyclooxygenase pathways. These inflammatory mediators then activate immune cells, cause blood vessel changes, and stimulate nociceptors to produce the sensation of pain.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    of 3

    Stimulus Phospo lipaseA2

    Steroids Cedera/Trauma
    Lipocortin

    NSAIDs

    Membran Sel

    Phospholipids

    Lipoxygenase
    Hydroperoxy And hidroxy fatty acid Leucotrie ne (LTD4 and C4 = SRS-A)

    Cyclooxygenase

    Prostaglandin Isomerase Prostaglandins -PGE2 -PGD2

    Thromboxane synthase
    Tromboxane-A2 Pistelet IP3 Aggregation Vasocontriction

    Prostacyclin synthase
    Platelet cAMP Dissagregation Vasodilatation

    Trauma/luka

    OPIOID
    Cedera/Trauma

    OPIOID

    Thalamus

    Reticular formation

    Membran Sel Neospinothalamic


    Phospolip ase-A2

    Paleospinothalamic

    Phospholipids NSAID Nociceptor

    Steroids

    Prostaglandin

    Lipoksigenase

    Siklooksigenase COX-1 COX-2


    Inflamasi

    Leukotrien
    LTB4 LTC4

    Aktivasi fagosit Peradangan

    PG fisiologis : Proteksi GIT Proteksi Ginjal Relaksasi otot polos Regulasi agregasi platelet

    PG patologis : Inflamasi Leukositosis Aktivasi Leukosit utk melepas sitokin

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