Professional Documents
Culture Documents
Dysregulation of Calcium Homeostasis After Severe Burn Injury in Children
Dysregulation of Calcium Homeostasis After Severe Burn Injury in Children
Klein GL, Nicolai M, Langman !, uneo !", #ailer D$, %erndon DN. Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0 5!, U"#$
%B&'(T)*'+ To determine the ca,se and extent of hypocalcemia o-served in children after severe -,rns$ D'")G.+ /e st,died 00 children 1ith -,rns coverin2 573 45- 073 6"D7 -ody s,rface area, a2es 8$9 45- :$7 years, 1ho 1ere admitted consec,tively d,rin2 a 9-month period$ Diet s,pplied a minim,m of !$7 2m5m! of calci,m, 0$ 2m5m! of ma2nesi,m, and !$! 2m5m! phosphate$ Blood specimens 1ere o-tained daily for 00 45- 5 days for the follo1in2 tests+ 607 sim,ltaneo,s analysis for ioni;ed calci,m, ma2nesi,m, and intact parathyroid hormone 62ro,p #7< 6!7 t1o of these children, randomly selected, had serial !-ho,r determinations on a sin2le day 62ro,p B7< 6 7 a modified 'lls1orth-=o1ard test, consistin2 of a 00-min,te inf,sion of synthetic parathyroid hormone 0> 45- 00 days post--,rn and associated chan2es in ,rinary cyclic adenosine monophosphate excretion and renal threshold phosphate concentration 62ro,p (7$ Three of these children, 1hen normoma2nesemic, also received a standard ma2nesi,m inf,sion to determine ma2nesi,m retention 62ro,p D7$ Data 1ere analy;ed 1ith chi-s?,are, re2ression analysis, and non-parametric testin2 as appropriate$
&$#'L(#: #ll patients sho1ed s,stained hypocalcemia and hypoma2nesemia< intact parathyroid hormone response 1as inappropriately lo1 and response to synthetic parathyroid hormone inf,sion 1as -l,nted$ @o1est ioni;ed calci,m levels 1ere associated 1ith hypoma2nesemia$ )N L'#*)N+ =ypoparathyroidism and -l,nted renal response to parathyroid hormone s,22est that ma2nesi,m depletion may contri-,te to their patho2enesis$ Ma2nesi,m repletion and monitorin2 are recommended$
PM)D+ 8!80900 AP,-Med - indexed for M'D@).'B
(a4
M24