Professional Documents
Culture Documents
Tumours of The Head and Neck
Tumours of The Head and Neck
Tumours of The Head and Neck
Introduction
Head and neck cancer is remarkable for its ability to cause extensive local tissue destruction and regional node involvement in the absence of distant metastasis
Introduction
Tumours are usually confined to the primary sites
Regional nodes & haematogenous metastasis are very rare and late in the disease process Loco-regional treatment by either surgery, radiotherapy or combination of the two is frequently curative
Introduction
Many of the oral lesions may have had an initial lesion that were potentially curable. The cure could be predicted if the lesion is diagnosed early and the appropriate therapy is given before the disease reaches advance stages to become incurable
Introduction
Cancer of the oral cavity in Saudi Arabia is not an uncommon disease It account for more than 25% of all malignancies, in the Southern region, it might reach up to 35% In males, it is third in frequency following lung and prostate cancer In females, it is second following breast cancer
Introduction
The spectrum of malignant tumours to affect the oral cavity vary widely and includes:
Surface epithelium
Squamous cell carcinoma over 90%
Glandular epithelium
Adenocarcinomas in females Mucoepidermoid carcinomas in males
Mesenchymal tissues
Lymphomas, Sarcomas are very rare
Introduction
Surface Epithelium
1- Squamous cell Carcinoma
Undifferentiated carcinoma Differentiated carcinoma Adenoid squamous carcinoma Verrucous carcinoma
Introduction
Glandular epithelium
1- Adenocarcinoma 2- Mucoepidermoid carcinoma 3- Adenoid cystic carcinoma 4- Acinic cell carcinoma 5- Undifferentiated carcinoma
Introduction
Mesenchymal tissues
1. Sarcoma
Fibrosarcoma Rhadomyosarcoma Osteogenic sarcoma Chondrosarcoma Neurogenic sarcoma Angiosarcoma Synovial cell sarcoma
Introduction
Prognostic Indicators:
Sex: Poor prognosis in females General condition & health status of patient T stage Number of histologically positive nodes Surgical margin status Type of therapy and blood transfusion
Introduction
Aetiology:
Smoking Alcohol consumption
They have synergistic role Burning tar gives off a variety of active substances e.g. benzopyrene, methyl cholanthrine, which will be broken by arylhydrocarbon hydroxylase into epoxide, carcinogen, that bind to the DNA
Introduction Aetiology
Chronic irritation from sharp jagged teeth Chemicals:
Asbestos, Nickel-Chromate, in nasal and paranasal sinuses tumours Wood dust in Adenocarcinoma of the nose
Dietary factors:
Vitamin A deficiency Vitamin B deficiency, Patereson-Kelly syndrome
Introduction
Acquired capability of cancer cell:
Limitless replicative potential Evading apoptosis Self-sufficiency in growth signal Insensitive to antigrowth signals Sustained angiogenesis Tissue invasion and metastasis
Assessment
Clinical Examination:
Tumours, when first seen, are almost always confined to the head and neck with no distant metastasis Head and neck tumours are rarely irremovable, all structures can be removed with the tumour in continuity and repaired later
The majority of cases are potentially treatable
Assessment
Whether to treat or not depend on:
the age the health status of the patient advance stage local disease
Assessment
Full assessment will lead to one of the following conclusions: Patient is potentially curable Primary tumour is curable but patient develop another illness Patient is incurable but should be treated Patient is incurable and should not be treated
Assessment
History:
Age:
Patient are generally over 45 years. Tumours affecting younger age group are usually sinister, defective immunological make-up Most tumours are of epithelial origin and they require years of abuse by smoking and tobacco Tumours in younger patients, who do not smoke, is usually very sinister Tumours developing in an immuno-compromised patients do not respond to any treatment modality
Assessment
Complaint:
Vary widely and is often unreliable Painless lump which persisted for a varying period of time Persistent ulceration Difficulty of wearing denture Later Symptoms:
Pain locally or referred to the jaw or ear Difficulty with chewing food and swallowing Altered speech and respiratory difficulty
Assessment
5.
Grade 4
Assessment
Examination:
Think in term of T Staging, delineate its border by inspection and palpation Record and draw the lesion from different angles using normal anatomical landmarks The status of teeth should be assessed as causative and if radiotherapy is to considered
Assessment
Staging of cancer:
Subdividing the malignant lesion into groups with similar behaviour
Act as a guide to appropriate treatment Act as a guide to prognosis Permits more reliable comparison of results
Primary site: Histological type, size and extend of the primary Node metastasis Haematogenous metastasis
Staging
Primary Tumour:
Indicated by the letter T and the suffix 1,2, 3 or 4 represent more advancing disease
Staging
Lymph node:
Is used to describe progressive lymph node involvement N1 Single epsilateral nodes 3 cm or less in diameter N2 Single epsilateral nodes more than 3 cm but less than 6
cm, or multiple clinically positive epsilateral less than 6 cm
N2a Single N2b Multiple
Staging
Distant metastasis:
M0 No metastases present M1 Metastases clinically demonstrable
MX Metastases cannot be assessed
Staging
TNM Staging:
Stage I: T1, N0, M0 Stage II: T2, N0, M0 Stage III: T3, N0, M0 T1, 2 or 3, N1, M0 Stage IV: T4, N0 or 1, M0 T1 4, N2 or 3, M0 T1 4, N1 3, M1 AJCC 1983
Staging
Stage I
compromise negative nodes and operable primary
Stage II
operable primary with operable nodes
Stage III
inoperable due advanced primary or advanced nodal involvement
Stage IV
Distant metastases preclude any surgical intervention
Surgical anatomy
The Lip:
Covered with non-keratinized stratified squamous epithelium which is transparent, appear red, and contain no hair, sebaceous gland or pigments On the vermilion border it closely cover the orbicularis oris muscle but on the lingual side mucous gland is present within the muscle and mucosa The epithelium is 2 mm away from the muscle, ulcerative lesions will be fixed early in the disease
Upper lip:
Drain into the periauricular, parotid, submandibular and submental lymph nodes
93% affect the lower lip with squamous cell carcinoma, exophytic type 5% in the upper lip and commonly basal cell carcinoma, commoner in females
Solar exposure, more radiation on the lower lip Commoner in fair complexion Smoker mainly pipe In the upper lip, SCC metastasizes earlier than lower lip
Surgical anatomy
The buccal mucosa:
Covered with nonkeratinizing stratified squamous epithelium with multiple minor salivary glands It is tight over the buccinator muscle and fixed to the upper and lower sulci Lymphatic drainage: The submandibular lymph nodes to the lower deep cervical chain
Surgical anatomy
The tongue:
Specialized keratinized epithelium with collection of minor salivary gland and muscle fibres The interlacing muscle fibres form an easy pathway for cancer spread and the constant movement of the tongue disseminates the disease widely
Excision should be wide with 2 cm safe margin
The tip and middle part of the tongue have rich bilateral capillary network but less in the lateral margins The U-shaped floor of the mouth drain to the submandibular lymph nodes Bilateral drainage from the anterior part of the U
Surgical anatomy
The floor of the mouth:
Anterior medial part:
Commoner than the lateral part Spread medially into the ventral surface of the tongue and laterally Deep spread to the base of the tongue and the hyoglossus and genioglossus muscles Shows bilateral lymphatic spread to the submandibular and the submental nodes
Deeper spread, mylohyoid muscle act as a barrier anteriorly, posteriorly the floor is close to the skin, appear as a palpable lump in the submandibular area
Surgical anatomy
The mandible:
Carcinoma of the lower alveolus affects the anterolateral part and spread to the floor of the mouth Tongue and floor of the mouth tumours reach the lower alveolus by marginal spread in the mucosa and submucosa overlying the sublingual, submandibular glands and the mylohyoid muscle.
Surgical anatomy
The hard palate:
Common location for carcinoma of the minor salivary gland
Presented as smooth, rounded, bulging masses
Surgical anatomy
The maxillary sinus:
The sinus is related to the orbit, nose, alveolar process, infratemporal fossa and nasopharynx. It has an outlet to the nose, ethmoid sinuses and the root of the teeth
The posterior ethmoidal air cell is separated from the optic nerve by a bar of bone but it is missing in 10% of cases and only encased in a sheath of dura, extension into the brain.
Aetiology:
Wood dust, nickel, shoe factory and mustard gas Snuff is a contributing factor
Adenocarcinoma:
Uncommon, occurs in people working in wood industry Histologically two types, high or low grade Invade bone and present the same way like SCC
Diagnostic Techniques
Tissue Biopsy:
This is the mainstay of tumor diagnosis coupled with high degree of suspicion
Diagnostic Techniques
Toluidine blue vital staining:
Acidophilic metachromatic nuclear stain that colors sites of squamous cell carcinoma but not adjacent normal mucosa surfaces 1 2% applied to dry surfaces and the dye diffuse into tissue through the large intercellular canaliculi
Diagnostic Techniques
Incisional:
Small portion of the lesion with the adjacent normal tissues to facilitate correct diagnosis
To visualize the transitional zone between tumor and normal tissue Performed at the periphery to avoid the necrotic central area
Excisional:
Removal of the entire lesion Done as a primary treatment
Surgical anatomy
Radiography:
Routine X-Ray studies:
Useful in cases of bony involvement
Panoramic views shows lytic lesions Lateral soft-tissue films shows the extend into the nasopharynx or hypopharynx
Angiography:
Define oral malignancy mainly avascular Shows the relation to major vessels prior to surgery Selective transcatheter embolization for bleeding control or decreasing tumor vascularity preoperatively
Diagnostic Techniques
Sialography:
Cannulation of parotid and submandibular ducts and the infusiopn of contrast material
CT-Scan:
Define the gross limits and determine the actual depth of tumor Evaluate adjacent bony structures and erosions involving the paranasal sinuses, base of skull and the cervical spine
Diagnostic Techniques
Nuclear Scanning:
The use of tumor-seeking radiopharmaceutical material
Bone scanning:
Uses Technetium 99-labeled phosphate complexes Very sensitive and positive in the presence of bony lesions before their detection by conventional radiographs Lacks specificity, infection, inflammation and even trauma result in positive scan
Diagnostic Techniques
Salivary gland scanning:
I.V. Technetium shows an increased uptake in papillary cystadenoma. Might occur with other benign or malignant tumors as a focal areas
Gallium-67 scanning:
Gallium isotopes concentrate in a rapidly growing tumors Best in epidermoid carcinomas and lymphomas Used in lymphoma staging
Diagnostic Techniques
Tumor markers:
Tumor markers are molecules occurring in blood or tissue that are associated with cancer and whose measurement or identification is useful in patient diagnosis or clinical management. Tumor markers are most useful for monitoring response to therapy and detecting early relapse They are generally products of the cancer cell, although none is unique to cancer cells; they represent aberrant tumor production of a normal element
Diagnostic Techniques
Tumor markers can be used for one of four purposes:
1- screening a healthy population or a high risk population for the presence of cancer 2- making a diagnosis of cancer or of a specific type of cancer 3- determining the prognosis in a patient 4- monitoring the course in a patient in remission or while receiving surgery, radiation, or chemotherapy.
Diagnostic Techniques
Carcinoembryonic Antigen CEA
The CEA was one of the first oncofetal antigens to be described and exploited clinically. It is a complex glycoprotein and is associated with the plasma membrane of tumor cells, from which it may be released into the blood. The primary use of CEA is in monitoring colorectal cancer, especially when the disease has spread and to check recurrence Other cancers produce elevated levels of this tumor marker, including lymphoma, head and neck cancer and cancers of the breast, lung, pancreas