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  • Iv. The Patient and His Illness A. Schematic Diagram Neonatal Sepsis (Book - Centered)

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    Kimm Charmaine Rodriguez
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    This document provides a schematic diagram of neonatal sepsis from both a book-centered and patient-centered perspective. From the book-centered view, it outlines non-modifiable and modifiable risk factors, the hyperdynamic phase, activation of the complement system, coagulation system and endothelium, endogenous mediator release, and complications including shock, multi-organ dysfunction syndrome and death. The patient-centered section notes the specific patient's non-modifiable risk factors, modifiable risk factors, signs and symptoms over time and abnormal lab results.

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    pathopysiology of sepisis

    Original Title

    Patho Sepsis

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    This document provides a schematic diagram of neonatal sepsis from both a book-centered and patient-centered perspective. From the book-centered view, it outlines non-modifiable and modifiable risk factors, the hyperdynamic phase, activation of the complement system, coagulation system and endothelium, endogenous mediator release, and complications including shock, multi-organ dysfunction syndrome and death. The patient-centered section notes the specific patient's non-modifiable risk factors, modifiable risk factors, signs and symptoms over time and abnormal lab results.

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    © All Rights Reserved
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    53 views4 pages

    Iv. The Patient and His Illness A. Schematic Diagram Neonatal Sepsis (Book - Centered)

    Uploaded by

    Kimm Charmaine Rodriguez
    This document provides a schematic diagram of neonatal sepsis from both a book-centered and patient-centered perspective. From the book-centered view, it outlines non-modifiable and modifiable risk factors, the hyperdynamic phase, activation of the complement system, coagulation system and endothelium, endogenous mediator release, and complications including shock, multi-organ dysfunction syndrome and death. The patient-centered section notes the specific patient's non-modifiable risk factors, modifiable risk factors, signs and symptoms over time and abnormal lab results.

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    of 4

    IV. THE PATIENT AND HIS ILLNESS A.

    SCHEMATIC DIAGRAM NEONATAL SEPSIS (BOOK CENTERED)


    NON -MODIFIABLE FACTORS >Common among male >common on pre term babies >common on developmental countries MODIFIABLE FACTORS >Congenital Infection >early onset infection >Late onset infection

    Focus of infection Superantigen Activated inflammatory cells Activation of host defense


    Hyperdynamic Phase >hypo/hyperthermia >tachypnea >tachycardia >metabolic demands >cardiac output

    Activation of complement system

    Activation of coagulation system

    Activated endothelium >increased multiplication >adhesion molecules increase

    Endogenous mediator release >pro-inflammatory cytokines >anti-inflammatory cytokines >platelet activating factor >arachidonic acid metabolites >myocardial depressant substance >endogenous opiates

    Sudden in cardiac output

    thrombomodulin plasminogen activator inhibitor Thrombosis and antifibrinolysis

    Hypovolemia Cardiac and vascular failure Capillary leak/ endothelial damage Acute respiratory distress Disseminated intravascular coagulation Decreased steroid synthesis

    >poor cardiac output >delayed capillary refill >Diminished peripheral and central pulses >cool extremities > urine output >alteration in mental status

    shock

    Multiorgan dysfunction syndrome (MODS)

    death

    Neonatal Sepsis (Patient Centered)


    NON -MODIFIABLE FACTORS >Common among male >common on developmental countries MODIFIABLE FACTORS >Late onset infection

    Focus of infection Superantigen Activated inflammatory cells Activation of host defense Maculopappular rashes (7-14-13) Vomiting (7-14-13) Watery stool (7-15-13) Feeding intolerance (7-15-13) tachypnea (7-15, 20,21,28-13)
    Endogenous mediator release >pro-inflammatory cytokines >anti-inflammatory cytokines >platelet activating factor >arachidonic acid metabolites >myocardial depressant substance >endogenous opiates

    Cold clammy skin (7-14-13)

    lymphocytes (7-14-13)

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