Professional Documents
Culture Documents
2013 Weight Reza WP v3
2013 Weight Reza WP v3
2013 Weight Reza WP v3
I N N O V AT I V E
I N G R E D I E N T S
I N S U P P O R T O F
W E I G H T
MA N A G E ME N T
AUTHORS:
MUHAMMED MAJ EED, PH. D. REZA KAMAREI , PH. D.
20 Lake Dr i ve , Ea s t Wi nds or, NJ 0 8 5 2 0
Te l : 7 3 2 . 777. 1111 Emai l : i nf o@s a bi ns a . c om We b: www. s a bi ns a . c om
ually uose:
o
300 mg ClLrln (l.e., 230 mg PCA), 3 umes a day (30-60 mln. before meals)
llg. 2 shows Lhe eecL of dally admlnlsLrauon of ClLrln on body welghL ln Lhls sLudy. As lL can be seen, Lhere
ls a modesL decrease ln body welghL aer 8 weeks - equally ln females and males. 1he mosL obvlous quesuon
ls abouL Lhe mechanlsm of acuon behlnd Lhe welghL loss. 1here are Lwo mechanlsms lnvolved here: lnhlbluon
of fauy acld synLhesls and sumulauon of fauy acld oxldauon ( oxldauon).
As far as lnhlbluon of fauy acld synLhesls ls concerned, PydroxyclLrlc Acld has 100 umes greaLer amnlLy for Lhe
enzyme clLraLe lyase, and, Lherefore, lL acLs as a poLenL lnhlblLor of clLraLe lyase. uue Lo Lhe lnhlbluon of
clLraLe lyase, very llule AceLyl CoA and Malonyl CoA are formed, whlch resulLs ln lnhlbluon of fauy acld
2012 - 2013 SABINSA CORPORATION 4
Female
B
o
d
y
W
e
i
g
h
t
(
l
b
s
)
Male All
250
200
150
100
50
0
Effect of daily administration of Citrin on body weight
Before Citrin
After 4 wks
After 8 wks)
llg. 2
synLhesls. As far as promouon of faL loss vla sumulauon of fauy acld oxldauon (or oxldauon) ls concerned,
fauy aclds are LransporLed lnLo mlLochondrla by llnklng wlLh L-carnlune. 1hls llnkage ls faclllLaLed by L-
carnlune Lransferase. As sLaLed above, ln Lhe presence of PCA, Malonyl CoA ls noL produced. 1he absence of
Malonyl CoA faclllLaLes Lhe oxldauon of fauy aclds.
ClLrln also aecLs appeuLe. llg 3 shows Lhe eecL of dally admlnlsLrauon of ClLrln on relauve appeuLe (self
assessmenL) ln Lhls sLudy. 1he way Lhls eecL happens ls as follows: 1he acuvauon of faL oxldauon by PCA ln
Lhe llver also Lends Lo sumulaLe gluconeogensls. 1hls replenlshes Lhe sLored glycogen sLorage ln llver. 1he hlgh
level of glycogen, as a resulL of hlgh glucose supply, ls LranslaLed by Lhe CenLral nervous SysLem as stote of
souety.
1he waLer-soluble poLasslum salL of ClLrln, l.e. ClLrln k, ls a self-amrmed C8AS (Cenerally 8ecognlzed As
Safe) subsLance wlLh Lhe recommended use level of up Lo 2,300 ppm ln selecLed non-alcohollc beverages (4.2
g/day for 70 kg person).
8ecenLly, a meLa-analysls of randomlzed cllnlcal Lrlals on Lhe use of Cotclolo exLracL (PydroxyclLrlc Acld) as a
welghL loss supplemenL was publlshed ln Lhe !ournal of CbeslLy (Cnakpoya eL al, 2011). 1he auLhors of Lhls
paper concluded LhaL Cotclolo exttocts/ncA coo coose sbott-tetm welqbt loss. 1be moqoltoJe of tbe e[ect ls
smoll." 1hls concluslon ls compauble wlLh Lhe small or modesL welghL loss shown ln llg 2. 1he reason for Lhls
observauon could posslbly be LhaL PCA ls poorly absorbed lnLo Lhe cyLosol of Lhe LargeL cell, llmlung lLs ablllLy
Lo lnhlblL clLraLe lyase. Whlle searchlng for an eecuve molecule LhaL faclllLaLes Lhe absorpuon of PCA lnLo Lhe
cyLosol, Lhe lngredlenL Cotclool became Lhe Lop candldaLe for conslderauon.
2012 - 2013 SABINSA CORPORATION 5
Female Male All
1.6
1.4
1.2
1
0.8
0.6
0.4
0.2
0
Effect of daily administration of on relative appetite -
self assessment
Citrin
Before Citrin
After 4 wks
After 8 wks)
B
o
d
y
W
e
i
g
h
t
(
l
b
s
)
llg. 3
M> !.")*+"*,-
CarClLrln ls a paLenLed (uS7,063,861, Au773081, nZ318116, Lu1234209 & !4203943) producL comblnlng
Lhe welghL managemenL beneLs of hydroxyclLrlc acld wlLh Lhe bloavallablllLy-enhanclng eecLs of garclnol, a
polylsoprenylaLed benzophenone lsolaLed from Carclnla cambogla 1he recommended use level of CarClLrln
ls 300 mg whlch conLalns 230 mg PCA and 23 mg Carclnol - Lhree umes a day.
8admaev, Ma[eed and ConLe compared ClLrln and CarClLrln (lnlually called new ClLrln") ln a cllnlcal Lrlal.
ueslgn of Lhe cllnlcal sLudy was as follows:
Sub[ecLs: 30 over-welghL sub[ecLs ln each group comprlslng of 24 Men and 26 Women ranglng ln age
from 23 Lo 33 years.