Mycotic diseases

 Mycotoxicoses
 Diseases associated with fungal toxin
 Accidental or ingestion of toxic fungi
 Their metabolites
 Ergot alkaloids
 Etiological agent
 Claviceps purpurea
Ergot alkaloids Cont.
 Source
 Infects grains
 Disease
 St. Anthony's fire
 Pharmacological and Clinical
Syndromes
 Alpha-adrenergic blocked
 Inhibits responses to epinephrine
 Ergot alkaloids Cont.
 Peripheral vasoconstriction
 5-hydroxytryptophamine restricts
the flow of blood
 Inflammation of infected tissues
 Necrosis (cell death)
 Gas gangrene
 Aflatoxins
 Etiological agent
 Aspergillus flavus
 Source
 Contaminated diary products
 Diseases
 Turkey X disease (birds)
 Cancer in humans
 Aflatoxins cont.

 Pharmacological and clinical syndroms

 Anorexia and muscle weakness
 Spasm and death
 Hemorrhage and necrosis of liver
 Tirchothecenes T-2 Toxin

 fusarium sporothricoides
 produced on cereal
 inhibit macromolecules synthesis
 cause immunosuppressive
activity
 Fumonisins
 Fusrium moniliforme
 Water on brain and lung
 Ochratoxin A and B
 Pencillium verrucosum
 Aspergillus ochraceus
 Causing nephropathy