Clinical Applications continues our commitment to enlisting experts in pharmacology to provide a textbook that is up-to-date and comprehensive. De- signed to be used during a single semester, the book fo- cuses on the clinical application of drugs within a con- text of the major principles of pharmacology. It is meant to serve students in medicine, osteopathy, dentistry, pharmacy, and advanced nursing, as well as undergrad- uate students. SUMMARY OF FEATURES This edition includes a number of new or updated fea- tures that further enhance the appeal of the text. Study Questions: Each chapter includes ve to seven examination questions (following the United States Medical Licensing Examination guidelines) with detailed answers to help students test their knowledge of the covered material. Case Studies: Appearing at the end of each chapter, case studies present students with real-life examples of clinical scenarios and require them to apply their knowledge to solve the problem. Rened Focus: In this edition, we chose to focus more on drug classes rather than on individual drugs, eliminate unnecessary detail such as chemical struc- tures, and maintain emphasis on structureactivity rela- tionships in drug action and development. Updated Information: This edition also includes new information from the clinic and the laboratory. Emerging information has been added within chapters and when appropriate (as in the case of herbal drugs and erectile dysfunction), through the addition of new chapters. With these revisions, we hope we have provided a book that is readable, up-to-date, comprehensive but not exhaustive, and accuratea text that supplies both students and faculty with a clear introduction to mod- ern pharmacotherapeutics. Charles R. Craig Robert E. Stitzel Preface