Kinase

Phosphatase
Transcription Factor
Caspase
Receptor
Enzyme
pro-apoptotic
pro-survival
GAP/GEF
GTPase
G-protein
Acetylase
Deacetylase
Ribosomal subunit
Direct Stimulatory
Modication
Direct Inhibitory
Modication
Multistep Stimulatory
Modication
Multistep Inhibitory
Modication
Tentative Stimulatory
Modication
Tentative Inhibitory
Modication
Separation of Subunits
or Cleavage Products
Joining of Subunits
Translocation
Transcriptional
Stimulatory Modication
Transcriptional
Inhibitory Modication
CELL SIGNALING TECHNOLOGY
www.cellsignal.com
Pathway Diagram Keys
Atg16L1
PI3K-I / Akt
Signaling
p53 / Genotoxic
Stress
Phagophore
Autophagosome
Lysosome
Cytoplasmic
Contents
Lysosome
Sequestration
Fusion
Autophagolysosome
Membrane
Nucleation
MAPK / Erk1/2
Signaling
Amino
Acids
Apoptosis
Raptor
GL
PRAS40
Beclin-1
PI3 Kinase
Class III
AMPK
LC3-I
PE
+ +
LC3
LC3-II Atg5
L
A
M
P
2
L
A
M
P
1
Atg14
Rubicon
Atg5
Atg12
Atg12
Atg7
Bcl-2
mTOR
p150
Atg16L1
Atg10 Atg3
SQSTM1/p62
NBR1
ALFY
Atg4
Atg7
ULK1
Atg13 FIP200
AMP:
ATP
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