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ЗАДАЧИ ПО ФАРМАЦЕВТСКА ХЕМИЈА 1-1
ЗАДАЧИ ПО ФАРМАЦЕВТСКА ХЕМИЈА 1-1
1. -
?
2.
:
) _____________________________________________________
) _______________________________________________________
3. . Hendersson-Hasellbach-
,
.
4.
6.4
5.
3.7
6. 1=2.4 2=6.8
7.
,
8.
,
9.
. .
10. = 4.5 , = 6.5 . .
11. = 2.8 , = 3.8 . .
12. .
.
3.5, ,
. 1.9,
( ).
13. = 6.2 , = 5.3 .
.
,
.
14. :
.
.
15. 1 2
16. .
?
.
17.
2 . :
) 100
) 1000
) 2
)
18. :
) /
) /
) /
19.
20. :
) /
) /
) /
21.
22. ( = 7.4)
( = 7.4)
23. :
, , .
.
1. log P log D.
2. log P = 2.3 , log P = 4.3.
?
3. log D
, .
4. log D
, .
5. (log P = 3.1,
= 7.6). log P = log D.
6. (log P = 2.7, = 3.8).
.
7. (log P = 2.8, = 6.7). log P = log D.
8.
9.
10. , .
?
11. : ( = 10.5), ( = 28)
( = 0.7), .
12. . 3
13. . 3
14.
15. D
16. log P
17. ( )
18. ( )
19.
20.
. (+) ,
21.
log P :
Cl
O2NO( )
( -)
S
,
-, ,
NO2 ()
NO2 ()
+ 0.5
+2.0
+0.5
+0.2
+0.65
0.0
-0.7
-0.7
-1.0
-1.0
-0.85
-0.85
22.
- (1=9.36, 2=7.42,
logP=1.48)
23. .
(
), ( )
:
1.
2. - (=6.8,
logS 0 =2.4)
3. - (=3.9,
S 0 =3.3gml-1)
4.
, ( ) .
5.
,
6. ,
:
) ____________________________________________
) ____________________________________________
7. ( )
8.
9. /
.
.