Dopamine is a naturally occurring organic amine that acts on alpha and beta adrenergic receptors and dopaminergic receptors, dilating renal and mesenteric blood vessels. It has a positive inotropic but little chronotropic effect on the heart, raising cardiac output and systolic blood pressure with little effect on diastolic blood pressure when infused intravenously. Dopamine is indicated for hemodynamic imbalances caused by conditions like shock, myocardial infarction, trauma, sepsis, open heart surgery, and acute or chronic heart failure. It has potential side effects like nausea, vomiting, arrhythmias, hypertension, and headaches.
Dopamine is a naturally occurring organic amine that acts on alpha and beta adrenergic receptors and dopaminergic receptors, dilating renal and mesenteric blood vessels. It has a positive inotropic but little chronotropic effect on the heart, raising cardiac output and systolic blood pressure with little effect on diastolic blood pressure when infused intravenously. Dopamine is indicated for hemodynamic imbalances caused by conditions like shock, myocardial infarction, trauma, sepsis, open heart surgery, and acute or chronic heart failure. It has potential side effects like nausea, vomiting, arrhythmias, hypertension, and headaches.
Dopamine is a naturally occurring organic amine that acts on alpha and beta adrenergic receptors and dopaminergic receptors, dilating renal and mesenteric blood vessels. It has a positive inotropic but little chronotropic effect on the heart, raising cardiac output and systolic blood pressure with little effect on diastolic blood pressure when infused intravenously. Dopamine is indicated for hemodynamic imbalances caused by conditions like shock, myocardial infarction, trauma, sepsis, open heart surgery, and acute or chronic heart failure. It has potential side effects like nausea, vomiting, arrhythmias, hypertension, and headaches.
Action :- It acts on alpha & beta adrenergic receptors. it additionally acts on dopaminergic (D2) receptors in renal & mesentric blood vessels, dilates them. ON HEART : it has positive inotropic but little chronotropic effect. Iv infusion raises cardiac output & systolic BP, little effect on diastolic BP. INDICATIONS : Hemodynamic imbalances present in shock syndrome caused by hypovolaemia, myocardial infarction, trauma. endotoxins septicaemia open heart surgery. acute renal failure & chronic cardiac decompensation in congestive failure. DOSAGE :- ADULTS : 2-50 mcg.kg.min can be increased upto 100 mcg/kg/min by slow iv infusion. CHILDREN : 2-20 mcg/kg/min. CONTRA INDICATION :- pheochromocytoma uncorrected tachycardia ventricular fibrilation hyperthyroidisom SPECIAL PRECAUTIONS : Dopamine must be diluted before iv administraion. hypovolamemia must be corrected before administrering.
SIDE EFFECTS : Nausea vomiting ectopic beats tachycardia anginal pain palpations hypotension dyspnoea headache vasoconstriction DRUG INTERACTIONS : Anaesthetics may cause cardiac arrhythmias, MAOIs increases the effect of dopamin.