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โรคพิษสุนัขบ้า
โรคพิษสุนัขบ้า
โรคพิษสุนัขบ้า
email : zoo_cdc@yahoo.com
website : http://thaigcd.ddc.moph.go.th
Facebook : Zoonosis Thailand
ISBN
978-616-11-1057-4
1 2555 3,000
1
I.
1.
1.1
1.2
1.3
2.
2.1
2.2
2.3
2.4
3. (post-exposure immunization)
3.1
3.2
3.3
4. (RIG)
4.1
4.2 RIG ERIG
4.3
4.4 RIG
5. (pre-exposure immunization)
II.
1.
2.
3.
3
5
6-8
9-60
10-26
10-13
10
11
12
14
14
14
14
14
14-19
14
16
19
20-22
20
21
22
22
23-26
24
25
26
27-33
27
30
30
34-38
III.
34
34
35
36
36
39-40
41-60
41
1
42
2 (.36)
44
3
45
46
4
48
5
52
6
54
7
57
8
(Necropsy)
58
9 ()
59
()
2
RIG
61-83
62
70
72
76
83
1
2
3 Direct Fluorescent Rabies
Antibody test (DFA)
4
5 ()
6 (Rabies Immunoglobulin : RIG)
7
8
10
11
13
14
19
20
29
31
84
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
1. 2 6
6
( 1 10 20 )
6 20
2 0 3 RIG
2. 1 2
(D0)
(D3)
1
2
3. 5 3
(D0)
(D3)
(D7)
IM-ID-ID-ID 2 D30
4. ID 2 IM
ID IM
5.
1.
2.
62
6.
6 1 6
2
7.
8.
6 1 6 2
9.
10. 3 10
4 5
11.
10
a.
b. 2
1
c.
63
12. RIG
.. 2545
13.
14.
( 1)
15.
3
RIG
16. 17
17.
18. Verorab
PCEC
64
19. 6
20. 0, 3 7
4 5
10
21. 3
()
22 28 30
3
23.
48
24.
25. 10 9
65
26. 3 3 5 ()
- 6 1 6
2 0 3
-
27. pre-exposure post-exposure 3
1 1
1 ( 3)
6
1 6 2 0 3
28. 3
( 7 1 )
( 2 1)
RIG
29.
2
- Pre-exposure prophylaxis ()
- Post-exposure prophylaxis
(treatment)
30. 2
*
* (Abrasion)
15
66
31. 14
2536
32.
2525
33. D30
- D30
-
1
34. 10
10
35. 3 5
- 3
- 5
1
36.
37. 2-4
. .. 2535
2-4
11
1-3
67
38. HIV
HIV
39. PCEC 8 RIG
PCEC 8
7
RIG 8
40. 2
41. 2
1
43.
Tetanus-diphtheria toxoid (Td) Tetanus toxoid (TT)
68
45. RIG
46.
47. Verorab
Tetanus toxoid
50.
2 1
51.
69
52. ()
14
53.
54. 0 10
55. ID 2-2-2-0-2 0, 3, 7 30 0, 3
3 14
( 10 )
56. 3
3
57.
- WHO
-
70
58. 0, 3, 7 2
3
- WHO
3 7
14
3
- 2-3
59. 0,3,7
24-48
3
60. 3 2
1 D4
2 D5
3 D6
3
1 2 3 D7 3 3
D8 D9
61. 7 14 double dose
schedule
62. PCEC 2 1
3
71
63. ID 2-2-2-0-2 0, 3, 7, 30 4
(D30)
10
64. 4
-
-
65. D0 D21
D28
66. ( ID IM)
RIG
67. 16 HRIG 320 IU
HRIG 300 IU
1
68. 20 HRIG 770 IU
HRIG 300 IU 75% ERIG
ERIG HRIG
ERIG
RIG
69. RIG
(ERIG 40 IU/kg HRIG 20 IU/kg)
72
70. RIG
1. 3
2. RIG 48
RIG 7 RIG
71. ERIG HRIG
7 48
72. 3
RIG
RIG
-
RIG
- RIG
73. HRIG ERIG
HRIG ERIG
1.
2.
3.
HRIG
(Human Rabies Immunoglobulin)
ERIG
(Equine Rabies Immunoglobulin)
1:100,000
4. (IU/kg) 20
40
5.
6.
2 ml (300 IU) 5 ml (750 IU) 5 ml (1000 IU)
73
74. RIG
1.
2. RIG OPD
card
3.
75. ERIG HRIG Maximum dose
ERIG 40 IU/kg HRIG 20 IU/kg
76. RIG
77. HRIG HRIG
78. RIG
RIG
HRIG HRIG
79. RIG
RIG
RIG
80. RIG
RIG
81. RIG
74
RIG rabies
virus
RIG
HRIG HRIG
ERIG
skin test
84. RIG
RIG RIG
75
89. RIG
()
RIG
90.
91.
92.
93.
94. rabies
- 2-8 7 1 (
2554 8 )
- 3-8 2 6
95. (Incubation Period)
1-6
96.
76
97.
98.
99.
100.
101.
102.
10
103.
Ampicillin
104.
15
105.
77
106.
. .. 2535
2-4
200
107.
.. 2535
433
108.
10
109.
110.
111.
78
112.
113.
114.
()
115.
2
1
116.
(2-8 C)
117.
118.
79
119.
120.
2-6
121.
122.
123.
124.
125.
126.
80
127. ()
SARS, Nipah, Ebola
128.
- Tetanus toxiod
toxiod
-
129. (
)
- 6
1 0.1 ml
- 6 2 0 3
1 0.1 ml
10
81
82
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2011; 79: 165-202.
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Difference in neuropathogenetic mechanisms in human furious and paralytic rabies.
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P, Chattranuklchai P, et al. Failure of rabies postexposure prophylaxis in patients
presenting with unusual manifestations. Clin Infect Dis. 2010; 50(1): 77-9.
Burton EC, Burns DK, Opatowsky MJ, El-Feky WH, Fischbach B, Melton L, et al. Rabies
encephalomyelitis: clinical, neuroradiological, and pathological findings in 4 transplant
recipients. Arch Neurol. 2005; 62(6): 873-82.
Maier T, Schwarting A, Mauer D, Ross RS, Martens A, Kliem V, et al. Management and outcomes after multiple corneal and solid organ transplantations from a donor infected
with rabies virus. Clin Infect Dis. 2010; 50(8): 1112-9.
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5.
1.
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