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  • Nrtis: Nrti: Zidovudine (ZDV) Azidothymidine (AZT) (Thymidine Analogue) ": Leukopenia, Anemia, GI

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    NRTI drugs like zidovudine (AZT) and lamivudine competitively bind to HIV's reverse transcriptase and become incorporated into the viral genome, preventing further DNA chain elongation due to their lack of a 3'-OH group. Common side effects of NRTIs include anemia, leukopenia, gastrointestinal issues, pancreatitis, peripheral neuropathy, and lactic acidosis. Entecavir is also used to treat hepatitis B virus.

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    nucleoside-analogue reverse transcriptase inhibitors

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    NRTIs

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    NRTI drugs like zidovudine (AZT) and lamivudine competitively bind to HIV's reverse transcriptase and become incorporated into the viral genome, preventing further DNA chain elongation due to their lack of a 3'-OH group. Common side effects of NRTIs include anemia, leukopenia, gastrointestinal issues, pancreatitis, peripheral neuropathy, and lactic acidosis. Entecavir is also used to treat hepatitis B virus.

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    5 views1 page

    Nrtis: Nrti: Zidovudine (ZDV) Azidothymidine (AZT) (Thymidine Analogue) ": Leukopenia, Anemia, GI

    Uploaded by

    AlaaAzzouqa
    NRTI drugs like zidovudine (AZT) and lamivudine competitively bind to HIV's reverse transcriptase and become incorporated into the viral genome, preventing further DNA chain elongation due to their lack of a 3'-OH group. Common side effects of NRTIs include anemia, leukopenia, gastrointestinal issues, pancreatitis, peripheral neuropathy, and lactic acidosis. Entecavir is also used to treat hepatitis B virus.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    of 1

    NRTIs

    NRTI:
    HIV:
    zidovudine (ZDV) = Azidothymidine (AZT) (thymidine analogue): leukopenia, anemia, GI
    It competitively binds to reverse transcriptase and is incorporated into the viral genome as a
    thymidine analog. AZT does not have a 3' -OH group, making 3'-5' phosphodiester bond
    formation impossible.

    Dideoxyinosine (didanosine, ddI): pancreatitis, peripheral neuropathy
    Dideoxycytidine (zalcitabine. ddC): pancreatitis, peripheral neuropathy, lactic acidosis
    Stavudine (d4t): peripheral neuropathy
    Lamivudine (3Tc, also against HBV)
    Emtricitabine (FTC)
    Abacavir (ABC): hypersensitivity (rash, fever, N/V, muscle & joint aches, SOB discontinue &
    never restart)

    HBV:
    Entecavir

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