Blood always Flows

Blood always remains

in the Liquid state

If something becomes
solid in the blood?


It will Block the blood flow
A mass formed in the blood which is
blocking the blood flow is
known as Thrombus
This phenomenon of Thrombus
formation is known as Thrombosis

Thrombosis
Thrombosis

Formation of solid mass in
circulation from the
blood constituents
Why the Blood clots ?
Why the Blood clots

inside the
intact vessel?

Rudolf Virchow
Endothelial Injury
Blood vessel wall integrity


Vessel wall releases :
Pro thrombotic factors & also
Anti thrombotic factors
Anti thrombotic factors :

Heparin like substance ,
Thrombomodulin , Inhibitors of platelet
aggrigation ADPase, PGI2 Tissue
plasminogen activator
Prothrombotic factors :

Thromboplastin , von Willebird
factor , Platelet activating factor ,
Inhibitor of plasminogen activator
Injury to the vessel wall



exposure of subendothelial
connective tissue
(Collagen, elastin, fibronectin, laminin)

Role of Platelets
Platelet adhesion
Platelet release reaction
Platelet aggrigation
Role of Coagulation system
It plays role in blood clotting
and also in thrombosis
Plasma Fibrinogen Fibrin
Hypercoagulability of
the blood
Increased coagulation factors
Increased Platelet Count and their
adhesiveness.
Decreased coagulation inhibitots
Antithrombin III

Alteration in the
Blood flow
Normal axial flow

Turbulance and Stasis