PATOLOGI ANATOMI

Basic science clinical practice

Promotif
Preventif
Curatif manage
Rehabilitatif

Promotif berperila!u sehat

Preventif " primer

" se!un#er
$iagnosti!
Curatif Manage Pera%atan
Theraph&
Ber#asar!an patogenesis ' patofisiologi
" (tiologi
" Pre#isposisi
" )a!tor &ang berperan
Patogenesis proses 'me!anisme*
step b& step
Morphologi changes
" +ub sel
" protein*$NA'RNA*gen*+ito!in
Micros " +el
" ,aringan
Macros " Organ
" +istem
)unctional changes

-ipo function

-iper function

Mal function
Clinical signal simptoms
To e.plain " /h&
" -o%
Patologi general path
s&stem path
N(OPLA+MA
(tiologi
01 Intrinsi! " Lesi geneti!
" Metabolism
" -ormonal
" #ll
21 (!strinsi!
" Mi!robiologi
" Chemical
" Ph&sical
" #ll
T3MOR " N(OPLA+MA
01 NON N(OPLA+MA
21 N(OPLA+MA

4LINI4 B(NIGNA
MALIGNA
-I+TOL M(+(NC-5M
(PIT(L
"hemopoetic
"neuroecto#erm
L(6(L T3B3-
+5+T(M
ORGAN
,ARINGAN
+(L
+3B +(L 7 C-ROMO+OM
G(N
$NA"RNA 'PROT(IN
N(OPLA+MA
A1 B(NIGNA
MALIGNA
A1 +(L (PIT(L
+(L M(+(NC-5M
+(L LAIN
B(NIGN 8 OMA 9 A$(NOMA B(NIGN 8 OMA 9 A$(NOMA
)IBROMA )IBROMA
LIPOMA LIPOMA
O+T(OMA O+T(OMA
MALIGNA MALIGNA

(PIT(L (PIT(L 8 CARCINOMA 8 CARCINOMA

9 9A$(NO CA A$(NO CA

M(+(NC-5M M(+(NC-5M 8 +ARCOMA 8 +ARCOMA

9 9 )IBRO +A )IBRO +A
NOM(NCLAT3R
PROLI)(RA+I TA4 T(R4(N$ALI
PROLI)(RA+I TA4 T(R4(N$ALI
01
01
PROGR(+I)* TA4 P(RL3 GRO/T- )ACTOR
PROGR(+I)* TA4 P(RL3 GRO/T- )ACTOR
21
21
P3RPO+(L(++
P3RPO+(L(++
:1
:1
()(4
()(4
;
;
,ARINGAN +(4ITAR
,ARINGAN +(4ITAR
<1
<1
TA4 B(RMAN)AAT
TA4 B(RMAN)AAT
=1
=1
PARA+ITI4
PARA+ITI4
>1
>1
TA4 TGT GRO/T- )ACTOR
TA4 TGT GRO/T- )ACTOR
?1
?1
L(++ A$-(+I6
L(++ A$-(+I6
@1
@1
$(+TR3CTI6
$(+TR3CTI6
+I)AT +(L N(OPLA+MA
BENIGNA MALIGNA
DEFERENSIASI MAT3R( ' BAI4 IMMAT3R( ' ,(L(4
MORFOLOGI SEL +PT NORMAL ABNORMAL
PERTUMBUHAN LAMBAT C(PAT
INVASI LOKAL ; 8
KAPSUL 8 ;
EFEK YG DITIMBULKAN 4OMPR(+I IN6A+I $(+TR34+I
GERAKAN MOBIL )IA($
RESIDIF ; 8
KLINIS $(+A4AN $(+TRO5+
OPERASI 9 BAI4 94OMBINA+I
METASTASE ; 8
PROGNOSE BAI4 B3R34
P(RB($AAN PO4O4
4AR+INOG(N(+I+
4AR+INOG(N(+I+
01 M3LTI )A4TOR
01 M3LTI )A4TOR
21 M3LTI -IT
21 M3LTI -IT
:1 M3LTI +T(P
:1 M3LTI +T(P
01 )A4TOR (AT(RNAL LING43NGAN B POL3+I 01 )A4TOR (AT(RNAL LING43NGAN B POL3+I
B3$A5A B3$A5A
4AR+INOG(N 4AR+INOG(N
MI4RO ORGANI+M( MI4RO ORGANI+M(
RA$IA+I RA$IA+I
4IMIA 4IMIA
)A4TOR INT(RNAL G(N(TI4 )A4TOR INT(RNAL G(N(TI4
-ORMONAL -ORMONAL
IMM3NOLOGI IMM3NOLOGI
M(TABOLI+M( M(TABOLI+M(
M3LTI )A4TOR
MI4RO ORGANI+M( " 6IR3+
" BACT(RI
4AR+INOG(N " ,AM3R
BA-AN 4IMIA
P-I+I4
6IR3+ -P6 6IR3+ -P6 Ca Cervic Ca Cervic
(B6 (B6 Ca NA+OP-AR5NA Ca NA+OP-AR5NA
-(PATITI+ -(PATITI+ Ca -(PAR Ca -(PAR

-TL6 -TL6 L(34(MIA L(34(MIA
LIM)OMA LIM)OMA
PROTO ON4OG(N " ON4OG(N PROTO ON4OG(N " ON4OG(N
T3MOR +3P G(N T3MOR +3P G(N
PROG C(LL $(AT- ' APOPTO+I+ PROG C(LL $(AT- ' APOPTO+I+
-IT B(R3NT3N* T(R3+ BM(N(R3+ -IT B(R3NT3N* T(R3+ BM(N(R3+

A43M3LA+I L(+I G(N A43M3LA+I L(+I G(N
GANGG3AN -OM(O+TA+I+ GANGG3AN -OM(O+TA+I+

ON4OG(N $OMINANT ON4OG(N $OMINANT
M3LTI -IT
M3LTI +T(P
01 +TA$I3M INI+IA+I
21 +TA$I3M PROMO+I
:1 +TA$I3M PROG(+I
N
IN
TC1
PROM
PM
(A1
PROG
M
MA++
"COMP " L3M(N
"$I+TR " 6A+A1 N
"IN)IL T1 OR
M(TA
PROMOTING IN-IBITING
ON4OG(N T3M1+3P 1G
APOP'PC$1G
$NA R(PAIR G1
-OM(O+TATI+ BALANC(
IMBALANC( " M3TATION
" M3LTIPLICATION
" $(GRA$ATION
INDIVIDUAL SEL :

DEFERENSIASI BAI4 * ,(L(4 * " TA4 B(R"$I)

ANAPLA+IA ATIPI4

PL(OMORP-I+M

ANI+O+ITO+I+

$I+PLA+IA

: +
+IC( +-AP( +TAINNING
KELOMPOK SEL/ STRUKTUR

AR+IT(4T3R

LO++ O) POLARIT5
BENIGN SOFT TISSUE
)IBROMA +3B C3TAN* O6ARI3M
)IB MOLL(
)IB $3R3M
4(LLOI$
M5AOMA L3NA4 * ,(RNI-
LIPOMA +3B C3TAN
P3NGG3NG * P3N$A4* (AT
C-ON$ROMA ,ARI
BATA+ T(GA+ * M(L(4AT
4(RA+
O+T(OMA LONG BON( * +43LL
M5OMA L(IO
R-AB$O

B(NIGN (PIT(LIAL T3MOR

A$(NOMA
D
4(L(N,AR +ALI6A
D
4(L(N,AR MAMMA
D
4(L(N,AR (N$OM(TRI3M
D
4(L(N,AR T-5ROI$
D
$LL

PAPILOMA
D
(PIT(L P(RM34AAN
D
M34O+A
MALIGNANT +O)T TI++3(
R-AB$OM5O B +ARCOMA
L(IOM5O B +ARCOMA
LIPO B +ARCOMA
O+T(O +ARCOMA
)IBRO +ARCOMA
N(3RO )IBRO +ARCOMA
MALIGNANT (PIT-(LIAL
T3MOR
A$(NO CARCINOMA
MI+
CARCINOMA (PI$(RMOI$
MI+
3N$I))(R(NTIAT($ CARCINOMA