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  • Lipid Lowering Drugs Lipid Lowering Drugs: HMG Coa Reductase Inhibitors (Statin)

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    This document summarizes different classes of lipid lowering drugs including their mechanism of action, effects on lipids, and side effects. The classes discussed are bile acid binding resins, niacin, fibrates, cholesterol absorption inhibitors, and HMG-CoA reductase inhibitors (statins). Bile acid binding resins work by binding bile acids in the intestine, lowering cholesterol levels. Niacin works by increasing lipoprotein lipase activity, lowering triglycerides and LDL while raising HDL. Fibrates work by increasing lipoprotein lipase activity as well, lowering triglycerides and possibly raising HDL while lowering LDL. Cholesterol absorption inhibitors work by inhibiting cholesterol absorption in the intestine. Statins work by inhibiting

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    Anti hyperlipidemic agent

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    Lipid Lowering Drugs

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    This document summarizes different classes of lipid lowering drugs including their mechanism of action, effects on lipids, and side effects. The classes discussed are bile acid binding resins, niacin, fibrates, cholesterol absorption inhibitors, and HMG-CoA reductase inhibitors (statins). Bile acid binding resins work by binding bile acids in the intestine, lowering cholesterol levels. Niacin works by increasing lipoprotein lipase activity, lowering triglycerides and LDL while raising HDL. Fibrates work by increasing lipoprotein lipase activity as well, lowering triglycerides and possibly raising HDL while lowering LDL. Cholesterol absorption inhibitors work by inhibiting cholesterol absorption in the intestine. Statins work by inhibiting

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    18 views1 page

    Lipid Lowering Drugs Lipid Lowering Drugs: HMG Coa Reductase Inhibitors (Statin)

    Uploaded by

    nizam_ghani
    This document summarizes different classes of lipid lowering drugs including their mechanism of action, effects on lipids, and side effects. The classes discussed are bile acid binding resins, niacin, fibrates, cholesterol absorption inhibitors, and HMG-CoA reductase inhibitors (statins). Bile acid binding resins work by binding bile acids in the intestine, lowering cholesterol levels. Niacin works by increasing lipoprotein lipase activity, lowering triglycerides and LDL while raising HDL. Fibrates work by increasing lipoprotein lipase activity as well, lowering triglycerides and possibly raising HDL while lowering LDL. Cholesterol absorption inhibitors work by inhibiting cholesterol absorption in the intestine. Statins work by inhibiting

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    © All Rights Reserved
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    of 1

    Lipid Lowering

    Drugs
    Bile acid
    binding
    resins (BAR)
    Niacin
    Fibrates
    (Fibric acid)
    MoA
    Effect on Lipid
    MoA
    Effect on Lipid
    Bind to bile acid in the intestine insoluble complex feces the liver uses
    cholesterol to make more bile which cholesterol levels

    VLDL synthesis

    TG
    LDL
    HDL GOOD
    LDL
    (may)TG
    HDL
    SE GI disturbance
    activity of lipoprotein lipase
    S/E pruritus
    Flushing. Prevent by taking aspirin 30 min in advance
    SE
    Cholesterol
    Absorption
    Inhibitors
    D/I
    PK
    powder form, taste "funny"
    absorbtion of
    NSAIDs, tetracycline, niacin, digoxin, warfarin, thyroxin, furosemide
    & thiazide
    Give the drugs at least 1 hr before Bile acid or 4 hrs after Bile Acid
    A, D, E, K & folic acid need supplements
    eg
    Cholestyramine & Cholestipol
    Little effect on levels of HDL-C and TG
    C/I
    diabetics
    Gout, Peptic ulcer
    C/I When there's a complete biliary obstruction
    MoA LipoProtein Lipase activity TG
    eg
    Effect on Lipid

    TG
    HDL
    Gemfibrozil & Fenofibrate
    MoA
    eg
    Effect on Lipid
    SE
    PK
    Ezetimibe
    inhibits absorption of cholesterol from small intestine
    Not absorbed, not metabolized, insoluble in water, huge molecule
    Excreted - feces
    PK
    oral
    Excreted - kidney
    myositis-like syndrome
    Oral
    Metab - liver
    HMG CoA
    Reductase
    inhibitors (Statin)
    MoA Inhibit HMG-CoA Reductase
    eg
    Effect on Lipid

    LDL
    TG
    HDL GOOD
    S/E
    Transaminases @ aminotransferase hepatotoxicity
    Myopathy
    (muscle ache&
    weakness)
    Myalgia
    Myositosis
    Rhabdomyolysis: muscle tissue breakdown (Creatine
    kinase@phosphokinase) which can cause
    myoglobinuria renal failure
    Monitor lab value
    liver functional enzymes
    Muscle enzymes (creatine phosphokinase)
    C/I
    PK
    Oral - take at night
    Metab: Liver
    GI upset, hyperglycemia, liver damage, uric acid
    as result of peripheral vasodilator
    Atorvastatin, Rosuvastatin
    pregnancy & lactation
    GI disturbance
    nausea, flatulance
    Constipation
    Overcome: forcing fluids and encouraging diet
    high in raw vegetables, fruit, and bran
    Headache,Diarrhea
    Headache
    Excrete Bile, feces
    C/I pregnancy & lactation
    Lithiasis:biliary cholesterol excretion formation of gallstones
    LDL
    May LDL with pt TG

    HDL
    LDL
    TG
    safe for pregnancy & children
    C/I hypertriglyceridemia
    lovastatin, pravastatin, simvastatin, fluvastatin
    potent
    GI disturbance Constipation, nausea & flatulence
    Normally: Well tolerate
    Lipid Lowering
    Drugs

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