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    Zidovudine: In-Vitro Dissolution Studies For Sustained Release Layer of

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    This document reports the results of in-vitro dissolution studies of different formulations of zidovudine (ZDV) and lamivudine (LMV) sustained and immediate release layers, as well as bilayer tablets. The percent of drug released was measured over time for each formulation (F1-F6). In general, F2 provided the fastest dissolution rates for both drugs while F5 and F6 exhibited slower, more sustained release profiles. The bilayer tablets showed dissolution profiles intermediate between the immediate and sustained layers, indicating successful combination of the two drug release mechanisms.

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    Zidovudine: In-Vitro Dissolution Studies For Sustained Release Layer of

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    This document reports the results of in-vitro dissolution studies of different formulations of zidovudine (ZDV) and lamivudine (LMV) sustained and immediate release layers, as well as bilayer tablets. The percent of drug released was measured over time for each formulation (F1-F6). In general, F2 provided the fastest dissolution rates for both drugs while F5 and F6 exhibited slower, more sustained release profiles. The bilayer tablets showed dissolution profiles intermediate between the immediate and sustained layers, indicating successful combination of the two drug release mechanisms.

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    This document reports the results of in-vitro dissolution studies of different formulations of zidovudine (ZDV) and lamivudine (LMV) sustained and immediate release layers, as well as bilayer tablets. The percent of drug released was measured over time for each formulation (F1-F6). In general, F2 provided the fastest dissolution rates for both drugs while F5 and F6 exhibited slower, more sustained release profiles. The bilayer tablets showed dissolution profiles intermediate between the immediate and sustained layers, indicating successful combination of the two drug release mechanisms.

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    Zidovudine: In-Vitro Dissolution Studies For Sustained Release Layer of

    Uploaded by

    jagruthims
    This document reports the results of in-vitro dissolution studies of different formulations of zidovudine (ZDV) and lamivudine (LMV) sustained and immediate release layers, as well as bilayer tablets. The percent of drug released was measured over time for each formulation (F1-F6). In general, F2 provided the fastest dissolution rates for both drugs while F5 and F6 exhibited slower, more sustained release profiles. The bilayer tablets showed dissolution profiles intermediate between the immediate and sustained layers, indicating successful combination of the two drug release mechanisms.

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    of 6

    IN-VITRO DISSOLUTION STUDIES FOR SUSTAINED RELEASE LAYER OF

    ZIDOVUDINE

    FORMULATIONS (% OF RELEASE)

    TIME (Hrs)

    F1

    F2

    F3

    F4

    F5

    F6

    1/2

    27.85

    33.35

    26.65

    10.28

    10.56

    8.78

    01

    40.71

    61.71

    29.35

    17.35

    10.71

    11.14

    02

    46.71

    77.14

    44.35

    18.20

    11.40

    12.08

    03

    51.73

    77.78

    52.92

    19.51

    13.02

    13.96

    04

    56.78

    79.71

    54.42

    20.78

    15.00

    15.42

    05

    57.11

    81.11

    56.78

    21.60

    18.06

    18.67

    06

    60.12

    82.29

    57.22

    22.89

    19.14

    19.39

    07

    62.59

    85.11

    59.16

    24.12

    21.29

    22.12

    08

    65.24

    86.97

    64.28

    25.99

    23.00

    23.59

    09

    68.18

    88.11

    65.24

    27.12

    24.12

    25.92

    10

    71.32

    92.51

    67.34

    28.75

    25.92

    26.78

    11

    76.15

    96.50

    71.34

    30.12

    27.22

    28.92

    12

    79.51

    97.79

    75.32

    32.24

    28.96

    29.34

    16

    38.14

    35.11

    37.12

    20

    45.42

    41.24

    42.26

    24

    52.33

    46.78

    44.51

    FORMULATIONS (% OF DRUG RELEASE)


    TIME (Hrs)

    ZDVF1

    ZDVF2

    ZDVF3

    ZDVF4

    ZDVF5

    ZDVF6

    1/2

    0.24

    0.32

    0.18

    0.26

    0.35

    0.38

    01

    0.48

    0.49

    0.14

    0.31

    0.42

    0.33

    02

    0.62

    0.69

    0.19

    0.36

    0.48

    0.41

    03

    0.58

    0.56

    0.25

    0.45

    0.52

    0.42

    04

    0.46

    0.45

    0.51

    0.62

    0.63

    0.58

    05

    0.17

    0.61

    0.45

    0.73

    0.85

    0.46

    06

    0.22

    0.82

    0.37

    0.62

    0.75

    0.62

    07

    0.56

    0.39

    0.43

    0.79

    0.65

    0.78

    08

    0.35

    0.37

    0.45

    0.73

    0.87

    0.58

    09

    0.49

    0.24

    0.51

    0.82

    0.67

    0.46

    10

    0.73

    0.35

    0.58

    0.58

    0.86

    0.62

    11

    0.46

    0.45

    0.31

    0.41

    0.47

    0.76

    12

    0.38

    0.27

    0.46

    0.51

    0.72

    0.64

    16

    62

    0.79

    0.89

    20

    0.59

    0.43

    0.94

    24

    0.74

    0.86

    0.731

    IN-VITRO DISSOLUTION STUDIES FOR IMMEDIATE RELEASE LAYER OF


    LAMIVUDINE

    FORMULATIONS (% OF RELEASE)

    TIME

    F1

    F2

    F3

    F4

    F5

    F6

    05

    40.40

    19.51

    21.44

    19.30

    23.80

    17.58

    10

    42.31

    24.87

    35.88

    26.94

    34.02

    29.45

    15

    45.53

    3.52

    44.34

    35.95

    47.53

    38.24

    20

    48.18

    40.31

    48.82

    42.96

    54.61

    48.25

    25

    50.11

    44.53

    50.82

    45.52

    62.11

    58.63

    30

    54.22

    54.18

    54.72

    50.25

    73.39

    65.32

    35

    62.11

    59.12

    61.12

    58.39

    79.84

    67.82

    40

    72.41

    68.11

    67.11

    66.11

    88.88

    76.32

    45

    79.42

    74.59

    72.32

    73.22

    97.37

    88.32

    50

    86.22

    82.33

    84.11

    86.12

    95.14

    55

    93.54

    88.11

    91.09

    87.11

    98.59

    60

    98.78

    95.59

    97.34

    94.32

    (Min)

    TIME
    (Min)

    FORMULATIONS (% OF DRUG RELEASE)


    LMVF1

    LMVF2

    LMVF3

    LMVF4

    LMVF5

    LMVF6

    0
    05

    0
    0.54

    0
    0.66

    0
    0.34

    0
    0.36

    0
    0.28

    0
    0.15

    10

    0.48

    0.53

    0.29

    0.64

    0.58

    0.32

    15

    0.62

    0.34

    0.18

    0.76

    0.26

    0.55

    20

    0.58

    0.63

    0.37

    0.34

    0.38

    0.74

    25

    0.46

    0.18

    0.12

    0.58

    0.33

    0.64

    30

    0.17

    0.57

    0.24

    0.52

    0.61

    0.32

    35

    0.22

    0.78

    0.27

    0.32

    0.79

    0.75

    40

    0.56

    0.55

    0.34

    0.23

    0.37

    0.56

    45

    0.48

    0.34

    0.41

    0.52

    0.60

    0.78

    50

    0.66

    0.58

    0.33

    0.23

    0.59

    55

    0.53

    0.12

    0.27

    0.37

    0.39

    60

    0.34

    0.27

    0.12

    0.67

    IN-VITRO DISSOLUTION STUDIES FOR THE BILAYER TABLETS OF


    ZIDOVUDINE AND LAMIVUDINE

    FORMULATIONS (% OF DRUG RELEASE)


    TIME

    F1

    F2

    F3

    F4

    F5

    F6

    1/2

    28.48

    25.12

    26.33

    24.33

    27.18

    29.28

    01

    41.24

    28.32

    29.14

    28.12

    29.26

    33.14

    02

    46.54

    33.44

    32.55

    32.45

    31.34

    36.28

    03

    49.20

    42.19

    38.67

    39.21

    34.97

    38.33

    04

    55.84

    51.22

    42.81

    41.48

    38.84

    41.51

    05

    57.18

    54.61

    48.09

    45.52

    41.56

    45.82

    06

    61.59

    61.72

    52.14

    49.69

    45.45

    47.91

    07

    69.33

    69.81

    56.63

    52.54

    48.47

    52.84

    08

    72.14

    73.48

    62.43

    54.32

    52.81

    54.22

    09

    74.28

    78.46

    68.56

    57.16

    54.12

    57.09

    10

    79.18

    81.56

    72.88

    62.12

    56.18

    59.28

    11

    81.42

    84.63

    75.17

    63.18

    56.01

    58.18

    12

    89.59

    89.76

    79.28

    64.88

    58.29

    62.34

    16

    92.63

    91.27

    80.24

    69.92

    61.33

    64.58

    20

    96.75

    93.84

    89.36

    71.44

    63.42

    66.16

    24

    98.19

    95.14

    91.14

    72.81

    65.06

    68.82

    (Hrs)

    FORMULATIONS (% OF DRUG RELEASE)


    TIME (Hrs)

    F1

    F2

    F3

    F4

    F5

    F6

    1/2

    0.18

    0.23

    0.23

    0.15

    0.34

    0.68

    01

    0.26

    0.36

    0.34

    0.28

    0.52

    0.56

    02

    0.41

    0.65

    0.45

    0.37

    0.54

    0.42

    03

    0.35

    0.45

    0.54

    0.43

    0.64

    0.25

    04

    0.56

    0.25

    0.69

    0.58

    0.69

    0.75

    05

    0.42

    0.52

    0.85

    0.64

    0.58

    0.56

    06

    0.52

    0.25

    0.37

    0.45

    0.84

    0.36

    07

    0.62

    0.43

    0.78

    0.47

    0.75

    0.41

    08

    0.36

    0.57

    0.24

    0.41

    0.65

    0.71

    09

    0.63

    0.68

    0.24

    0.65

    0.85

    0.55

    10

    0.56

    0.64

    0.36

    0.75

    0.79

    0.64

    11

    0.68

    0.24

    0.41

    0.56

    0.65

    0.42

    12

    0.78

    0.85

    0.67

    0.65

    0.42

    0.52

    16

    0.24

    0.42

    0.52

    0.52

    0.41

    0.98

    20

    0.58

    0.48

    0.44

    0.36

    0.48

    0.43

    24

    0.36

    0.89

    0.65

    69

    0.64

    0.78

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