Tabel . Mekanisme resistensi antibiotik yang umum digunakan.

Wright, G. D., and M. Morar. The genomic enzymology of antibiotic resistance. Annu.
Rev. Genet., in press.
Antibiotik Contoh Target Mekanisme Resistensi
-Lactams Penicillins (ampicillin),
cephalosporins (cephamycin),
penems (meropenem),
monobactams (aztreonam)
Peptidoglycan
biosynthesis
Hidrolisis, efflux,
altered target
Aminoglikosida Gentamisin, streptomisin Translasi Fosforilasi, asetilasi,
nukleotidilasi, efflux,
altered target
Glikopeptida Vankomisin Biosintesis
peptidoglikan
Reprogramming
peptidoglycan
biosynthesis
Tetrasiklin Minosiklin, tigesiklin Translation Monooksigenasi, efflux,
altered target
Makrolida Eritromisin, azitromisin Translasi Hidrolisis, glikosilasi,
fosforilasi, efflux,
altered target
Linkosamida Klindamisin Translasi Nukleotidilasi, efflux,
altered target
Oksazolidin Linezolid Translasi Efflux, altered target
Fenikol Kloramfenikol Translasi Asetilasi, efflux, altered
target
Kuinolon Siprofloksasin Replikasi DNA Asetilasi, efflux, altered
target
Pirimidin Trimetoprim C
1
metabolism Efflux, altered target
Sulfonamida Sulfametoksazol C
1
metabolism Efflux, altered target
Rifamisin Rifampin Transkripsi ADP-ribosylation,
efflux, altered target