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    Sahid Suparasa: Divisi Ilmu Penyakit Dalam RSUD Wahidin Sudirohusodo Mojokerto

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    Renita Siwi M W
    This document discusses the etiology, diagnosis, and treatment of septic shock. [1] Septic shock can be caused by various factors that lead to circulatory failure including infection, obstruction, or blood loss. [2] It is diagnosed when a patient presents with signs of systemic inflammatory response syndrome (SIRS) along with a confirmed infection and decreased consciousness. [3] Treatment involves supporting respiration, circulation, and hemodynamics, providing adequate calories and antibiotics, using vasopressors, and treating the underlying cause and source of infection.

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    Sahid Suparasa: Divisi Ilmu Penyakit Dalam RSUD Wahidin Sudirohusodo Mojokerto

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    Renita Siwi M W
    12 views15 pages
    This document discusses the etiology, diagnosis, and treatment of septic shock. [1] Septic shock can be caused by various factors that lead to circulatory failure including infection, obstruction, or blood loss. [2] It is diagnosed when a patient presents with signs of systemic inflammatory response syndrome (SIRS) along with a confirmed infection and decreased consciousness. [3] Treatment involves supporting respiration, circulation, and hemodynamics, providing adequate calories and antibiotics, using vasopressors, and treating the underlying cause and source of infection.

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    This document discusses the etiology, diagnosis, and treatment of septic shock. [1] Septic shock can be caused by various factors that lead to circulatory failure including infection, obstruction, or blood loss. [2] It is diagnosed when a patient presents with signs of systemic inflammatory response syndrome (SIRS) along with a confirmed infection and decreased consciousness. [3] Treatment involves supporting respiration, circulation, and hemodynamics, providing adequate calories and antibiotics, using vasopressors, and treating the underlying cause and source of infection.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    12 views15 pages

    Sahid Suparasa: Divisi Ilmu Penyakit Dalam RSUD Wahidin Sudirohusodo Mojokerto

    Uploaded by

    Renita Siwi M W
    This document discusses the etiology, diagnosis, and treatment of septic shock. [1] Septic shock can be caused by various factors that lead to circulatory failure including infection, obstruction, or blood loss. [2] It is diagnosed when a patient presents with signs of systemic inflammatory response syndrome (SIRS) along with a confirmed infection and decreased consciousness. [3] Treatment involves supporting respiration, circulation, and hemodynamics, providing adequate calories and antibiotics, using vasopressors, and treating the underlying cause and source of infection.

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    of 15

    Sahid Suparasa

    Divisi Ilmu Penyakit Dalam


    RSUD Wahidin Sudirohusodo
    Mojokerto
    Etiologi :
    Syok Kardiogenik
    Syok Obstrutif ( temponade perikardium,
    koartasio aorta, emboli paru, HT pulmoner
    primer )
    Syok Oligemik / Hipovolumik
    Syok Distributif ( Septik, anafilaktik,
    neurogenik )

    # SIRS /systemic inflamatory respon
    syndroma : ( 2 atau lebih )
    Suhu > 38 C atau < 36 C
    Nadi > 90 x/mnt
    Respirasi > 20 x/mnt
    atau PaCO2 < 32 mm/Hg
    lekosit > 12000 / < 4000
    # SEPSIS SIRS + sumber infeksi dan /
    penurunan kesadaran
    # SYOK SEPTIK sepsis + gangguan perfusi
    / hipotensi
    # Sepsis Syok septik GMO /MODS
    Pathophysiology

    -Renal
    failure
    - Hepatic
    failure
    -Metabolic
    Systemic failure
    Pathogenetic inflammatory
    Local Systemic response Cardiovascular -Respiratory
    microorganism inflam. inflam. plus evidence insuficiency insuficiency- death
    Death
    response response of inadequate
    organ -Gastrointestinal
    perfusion failure
    - Immune system
    failure
    - Central nervous
    system failure
    - Hematologic
    failure

    Clinical entity Local Sepsis Sepsis Septic
    infection syndrome shock

    Multiorgan failure

    # Penatalaksanaan :
    Suport respirasi, sirkulasi & hemodinamik
    Masukan kalori yg cukup
    Antibiotik : empiris / sesuai kultur
    Vasopressor
    Tx penyakit dasar
    Tx sumber infeksi

    Principal Therapeutic Concepts
    Infection
    Toxines
    Mediatores
    SIRS
    septic shock
    MODS
    Antibiotics
    Neutralisation :
    immunoglobulines
    Antagonisation :
    TNF, interleukines
    Elimination :
    hemofiltration
    Supportive therapy
    Reaksi alergi :

    # Tipe I alergen + IgE mast cell histamin
    + mediator inflamasi
    # Tipe II IgM / IgG hapten + komplemen
    reaksi sitotoksik
    # Tipe III alergen + Ab aktivasi komplemen
    + inflamasi
    # Tipe IV / tipe lambat limfosit pelepasan
    sitokin + mediator inflamasi

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