Kim tra bi c

Ti sao ngi ta ni virus l mt

dng sng c bit?
VR cha c cu to TB, nhng vn c kh
sng, sinh sn trong TB ch( trong TB vt
ch VR hot ng nh 1 th sng, ngoi TB
chng li nh 1 th v sinh).

S nhn ln ca virus trong t
bo bnh AIDS
Bi 44
I. Chu trnh nhn ln ca virus
1. Chu trnh sinh tan
Hy quan st 2 on bng sau v cho
bit:
C th chia chu trnh nhn ln ca
virus thnh my giai on ?
l nhng giai on no ?
Chu trnh nhn ln ca virus ng
vt
Chu trnh nhn ln ca phage
Chu trnh nhn ln ca virus gm
5 giai on :
1. Hp ph
2. Xm nhp
3. Sinh tng hp
4. Lp rp
5. Gii phng
G1: hp ph
virus ng vt
Phage
Trong giai on hp ph, virus
thc hin hot ng g?
virus bm mt cch c hiu
ln th th b mt t bo
G1: S hp ph
virus ng vt
Phage
virus c th bm c hiu ln
loi t bo m n k sinh l nh
yu t g ?
Nh c gai glycprtin (virus ng vt) v gai
ui (phage) c tc dng khng nguyn, tng hp vi
cc th th trn b mt t bo
Gai
glycprtin
Gai ui
G1: S hp ph
virus ng vt
Phage
Gai
glycprtin
Gai ui
S bm c hiu ca virus trn b
mt t bo c ngha g?
Mi loi virus ch c th k sinh
trong mt loi t bo nht nh
G2: xm nhp
virus ng vt
Phage
Qu trnh xm nhp ca phage v
ca virus ng vt khc nhau nh
th no ?
Phage: Enzim lizzim ph
hu thnh t bo bm
axit nuclic vo t bo
cht, v nm bn ngoi.
VRV: a c
nuclcapsit vo t bo
cht, sau ci v
gii phng axit Nuclic
G3: Sinh tng hp
Trong giai
on ny,
virus tng
hp nhng vt
cht no ?
virus thc
hin qu trnh
tng hp axit
nuclic v
prtin ca
mnh
Cc nguyn liu v enzim m
virus s dng c ngun gc t
u?
Ngun nguyn liu v enzim:
do t bo ch cung cp
G4: Lp rp
Din bin
ca giai
on ny
nh th
no?
Lp rp axit nuclic vo prtin
v to thnh virus hon
chnh.
G 5: gii Phng
Trong giai
on ny,
hot ng
ca virus nh
th no?
virus ph v
t bo ch
t chui
ra ngoi.
Bng cch no virus c th ph
v t bo chui ra ngoi?
( virus c h gen m ho enzim
lizzim lm tan thnh t bo vt
ch)
Bi tp
in tn cc giai on
trong chu trnh sinh tan
ca virus
virus
Hp ph
Xm nhp
Sinh tng hp Lp rp
Gii phng
(1)
(2)
(3)
(4)
(5)
2. Chu trnh tim tan
Trong chu trnh
tim tan, hot
ng ca virus
din ra nh th
no? c im g
sai khc so vi chu
trnh sinh tan?
virus gn ADN ca mnh vo ADN ca
vt ch v nhn ln cng vi t bo vt ch
Chu trnh sinh
tan
Chu trnh tim tan
Da vo hai on phim trn, hy cho bit:
Th no l chu trnh sinh tan?
Th no l chu trnh tim tan?
Khi virus
nhn ln m
lm tan t bo
th gi l chu
trnh sinh tan
Khi ADN ca virus gn
xen vo NST ca t bo
m t bo vn sinh trng
bnh thng th gi l chu
trnh tim tan
3. Mi quan h gia chu trnh sinh tan v chu
trnh tim tan
Chu trnh sinh
tan v tim tan
c quan h vi
nhau nh th
no?
Khi cm ng( chiu tia UV), virus
ang trng thi tim tan c th chuyn
thnh trng thi sinh tan.
S mi quan h gia chu
trnh
sinh tan v tim tan
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
Hp ph
Xm nhp
Sinh tng hp
Lp
rp
Gii
phng
Ci
xen
Nhn
ln
Cm
ng
(TB tim tan)
II. HIV/ AIDS
BNH AIDS
Tc nhn: Con ngi b ly nhim virus HIV
t nhng ging kh dng ngi c tr ti
Trung Phi, nhiu kh nng nht l t
Shimpanze. c ti gn 24 triu ngi cht
v AIDS.
Con ngi b ly nhim virus HIV t nhng
ging kh dng ngi c tr ti Trung Phi
Ngi b bnh AIDS
virus HIV
Typ HIV I gy bnh ph bin trn th gii,
HIV II gy bnh ch yu chu Phi.
C 2 typ ny c Luc montagnier v Robert
Gallo phn lp.
Typ I phn lp Php nm 1983 v typ II
chu Phi nm 1986 ( Ghinea-Bissau c t
tn l HIV-2)
> Robert Gallo v Luc Montagnier
1. Khi nim v HIV/ AIDS

virus HIV l g
?
HIV l virus gy suy gim
min dch ngi
Ngi b nhim VR
HIV s b bnh
g? Biu hin
lm sng ca
bnh?
VR HIV gy nn bnh
AIDS, vi biu hin:
St ko di, st cn,
tiu chy,vim da...
1. Khi nim v HIV/
AIDS

Ti sao VR HIV li
gy nn bnh
AIDS vi cc biu
hin nh vy?
VR HIV gy nhim v ph hu
cc t bo ca h thng min
dch mt kh nng min dch
ca c th (bnh AIDS- hi
chng suy gim min dch
mc phi ngi)
cc VSV khc li dng
c th b suy gim min
dch tn cng ( VSV c
hi)
C
th d nhim bnh ( bnh c
hi)
Cc t bo m HIV tn
cng
i thc bo
T bo
limphoT
2.Cc con ng ly truyn HIV
Mu
Tnh dc
M truyn sang
con
HIV/AIDS thng ly truyn
qua nhng con ng no?
Nghin cu SGK phn Cc
giai on pht trin ca bnh
v hon thnh phiu hc tp
sau trong thi gian 5 pht.
3. Cc giai on pht trin ca
bnh
Giai on Thi gian
ko di
c im
1. S nhim
2. Thi k
khng triu
chng
3. Thi k biu
hin triu
chng AIDS
2 tun -3
thng
Khng c triu
chng
1-10
nm
S lng t bo
Limph T4 gim dn
Sau 1
n 10
nm
Xut hin cc bnh
c hi: st,tiu chy,
st cn, ung th
cht
4. Cch phng trnh
AIDS
Hiu bit v AIDS
Sng lnh mnh
Loi tr t nn x hi
V sinh y t

Chng ta c th phng trnh
HIV/AIDS bng cch no?
Hin nay c thuc cha c
cc bnh do virus ni chung v
virus HIV ni ring cha? Ti sao
?
Do virus k sinh trong t bo do
cc thuc khng sinh khng tc
ng c n virus, hoc trc khi
tiu dit c virus th chnh thuc
ph hu t bo
Bin php tt nht chng
li cc bnh do virus hin nay
ang c s dng l g ?
Tim vcxin phng bnh nh k
ti cc trung tm y t (di, si,
quai b, u ma)
Chu trnh nhn ln ca virus HIV
trong t bo Limph T4
Chu trnh nhn
ln ca HIV
trong t bo
Limph T4 c
th c chia
thnh my giai
on? l
nhng giai on
no?
C 7 giai on:
1. Hp ph
2. Xm nhp
3. Sao m ngc
4. Ci xen (tin virus)
5. Sinh tng hp
6. Lp rp
7. Gii phng
CHU TRNH SNG CA RETROVIRUS

S chu trnh nhn ln ca virus
HIV
trong t bo Limph T4
Hp ph
Xm nhp
Sao m ngc
ARN
ARN
ADN
Ci xen
Sinh tng
hp
Prtin
HIV mi
Gii phng
Lp
rp