Regulatory T cells: CD3,CD4, CD25 AND TRANSCRIPTION FACTOR FOXP3. PROD IL-10, TGF-B.

B cells Ig (binds antigen)

CD19, CD20, CD21 (receptor for EBV), CD40
MHC II, B7
Macroph: CD14(ENDOTOXIN RECEPTOR).
NK CD16 (BINDS FC OF IGG)AND CD56.
mast cells and
basophils, triggering immediate release of
vasoactive amines that act at postcapillary
venules (i.e., histamine).
Type IV Multiple sclerosis
Guillain-Barr syndrome
Graft-versus-host disease
PPD (test for M. tuberculosis)
Contact dermatitis (e.g., poison ivy, nickel
allergy).
Anti-glutamate decarboxylase Type 1 diabetes mellitus.
Burtons: ABSENT CD19+ BCELLS.
SELECTIVE IGA DEF: IGA <7MG/DL.
COMMON VARIABLE IMMUNODEF: DEC PLASMA CELLS.
Digeorge: tetralogy of fallot, truncus arteriousus.
Hyper IgE syndrome(job syndrome): STAT3 MUTATION. AUT DOM. DEF TH17. ECZEA, RETAINED
PRIMARY TEETH, COLD STAPH ABSCESS. DECREASED NEUTROPHIL RECRUITMENT.
SCID:

Several types including
defective IL-2R gamma chain
(most common, X-linked. Decreased TCR excicion circles. Absence of thymic shadow, germinal centers and t
cells.
Ataxia-telangiectasia Defects in ATM gene DNA
double strand breaks cell
cycle arrest.
Triad: cerebellar defects
(Ataxia), spider Angiomas
(telangiectasia), IgA
deficiency.
AFP.
IgA, IgG, and IgE.
Lymphopenia, cerebellar
atrophy.
Hyper IGM synd, x linked recessive.

Wiskott-Aldrich
syndrome
Mutation in WAS gene
(X-linked recessive); T cells
unable to reorganize actin
cytoskeleton.
WATER: Wiskott-Aldrich:
Thrombocytopenic purpura,
Eczema, Recurrent
infections.
risk of autoimmune disease
and malignancy.
to normal IgG, IgM.
inc IgE, IgA.
Fewer and smaller platelets.

Leukocyte adhesion
deficiency (type 1)
Defect in LFA-1 integrin
(CD18) protein on
phagocytes; AR.
CHEDIAK: AR.
CGD: X LINKED R. ABNORMAL DIHYDRORHODAMINE TEST(FLOW CITOMETRY.) 240 2287