Scribd Logo
Upload

Welcome to Scribd!

  • 2 views

    Exploring Local Circuit Mechanisms of Human Neocortex: Allen Institute

    Uploaded by

    psturmer11
    Dr. Smith gave a talk on exploring the local circuit mechanisms of the human neocortex using array tomography. He discussed the differences between studying acute brain samples versus cultured brain samples, noting that cultured samples allow the study of live neuronal voltage-current behavior. Dr. Smith also noted the complexity of the brain and its ability to continually build itself. The second document discusses a paper that argues there is more diversity within synaptic classifications than previously thought, which has implications for understanding the brain. It highlights the need for more exploration into this new level of synaptic diversity.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content

    You might also like

    Exploring Local Circuit Mechanisms of Human Neocortex: Allen Institute

    Uploaded by

    psturmer11
    2 views1 page
    Dr. Smith gave a talk on exploring the local circuit mechanisms of the human neocortex using array tomography. He discussed the differences between studying acute brain samples versus cultured brain samples, noting that cultured samples allow the study of live neuronal voltage-current behavior. Dr. Smith also noted the complexity of the brain and its ability to continually build itself. The second document discusses a paper that argues there is more diversity within synaptic classifications than previously thought, which has implications for understanding the brain. It highlights the need for more exploration into this new level of synaptic diversity.

    Original Description:

    a response

    Original Title

    NBIO Week 1

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Dr. Smith gave a talk on exploring the local circuit mechanisms of the human neocortex using array tomography. He discussed the differences between studying acute brain samples versus cultured brain samples, noting that cultured samples allow the study of live neuronal voltage-current behavior. Dr. Smith also noted the complexity of the brain and its ability to continually build itself. The second document discusses a paper that argues there is more diversity within synaptic classifications than previously thought, which has implications for understanding the brain. It highlights the need for more exploration into this new level of synaptic diversity.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    2 views1 page

    Exploring Local Circuit Mechanisms of Human Neocortex: Allen Institute

    Uploaded by

    psturmer11
    Dr. Smith gave a talk on exploring the local circuit mechanisms of the human neocortex using array tomography. He discussed the differences between studying acute brain samples versus cultured brain samples, noting that cultured samples allow the study of live neuronal voltage-current behavior. Dr. Smith also noted the complexity of the brain and its ability to continually build itself. The second document discusses a paper that argues there is more diversity within synaptic classifications than previously thought, which has implications for understanding the brain. It highlights the need for more exploration into this new level of synaptic diversity.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    of 1

    PaulSturmer

    NBIO490
    HW1:Dr.Smith

    ExploringLocalCircuitMechanismsofHumanNeocortex:AllenInstitute
    Thiswasadisappointingtalkgiventheambitioustitleofexploringlocalcircuitmechanismsof
    humanneocortex.Dr.Smithstartedthetalkintroducingarraytomographyandtheintellectual
    propertysurroundingit.Hemadeanimportantdistinctionbetweenacuteandculturedbrain
    samples,thelattershowingbetterpotentialbutstillneedingadvancement.Forexample,a
    culturedsampleallowaresearchertostudythevoltagecurrentbehaviorinliveneurons,
    whereasanacutesamplecouldntelucidatethesefeatures.AnotherinterestofDr.Smithwas
    thebeautythebraincontains:itisgreatlycomplexallthewhilestillbuildingitself.

    Fromarticle:DeepMolecularDiversityofMammalianSynapses:WhyItMattersandHow
    toMeasureIt
    Anundergradistaughtaboutthevarioustypesofsynapses.Pushingthisconceptfurther,this
    paperpurportsthatanotherlevelofdiversityexistswithinthisnaiveclassificationsystem.The
    implicationsofthisideaaredrasticbecauseunderstandingthesesynapsesispivotalto
    understandingthebrain.Thispaperstartstofillinsomeofthesenewdetails,suchas
    discussingresponseprobabilityofGABAergicinterneuronsandtheimportanceofdiversity.The
    storyisnotyetcomplete.Thispapermostlyservestohighlighttheneedformoreexplorationinto
    thisnewlevelofdiversity.

    You might also like