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Obat Saluran Cerna Klas Internasional 3
Obat Saluran Cerna Klas Internasional 3
disorder
1. Antasida
2. Antagonis reseptor histamine 2 dan Proton bloker
3. Spasmolytic (anti spasmodic)
4. Laxantia
5. Diare non spesifik
6. Infection located in gastro intestinal
7. Kolelitolytic and Hemorhoid drug
8. Hepatoprotektor and Regulator gastrointestinal tract.
1. Antasida is a group of drug can decrease gaster acidity
Weak alkaline.do not decrese acid production
Decrease acid capacity depends on type of antasida , intake frequency and
velocity of emptying gaster
Increase Ph causes decrease pepsin activefity
A. Na HCO3
- Antasida sistemik.,urine alkalis,alkalis metabolic
- Poten antasid ,on set of action ,fast and short duration
- Yield CO2 buble ,gaster distension ,Tablet 500 mg,dosis 1-4 gr
B. Al(OH)3
- Non sistemik antasida
- On set of cation slow, long action/ duration
- React with phosphat ( come from food),with protein became
adstrigen
- Pepsin no active, cause constipation
- Decrease adsorbtion vitamin and Tetrasiklin
- Tablet 600 mg dan suspensi 3,6-4,4 %
C. CaCO3
- Poten Antasida, partly absorbtion
- On set of cation fast, long acting
- cause acid rebound, Constipation,nausea,vomiting
- Tablet 600 mg,dosis 1-2 gr
D. Mg(OH)2 and Mg CO3
- Onset of action slow
- Absorbtion 5 -10%, can cause diare
- Ca cause CV.neurologik and neuromuskuler disorder,alkaliuri
- Tablet 325 mg dan suspensi 7-8,5% Mg(OH)2
Mg trisilikat
Mg2Si308 nH20 + H+ ------2Mg++ + 3SiO2 + (n+2) H2O
- SiO2 to form gel covers ulcus, adsorb gas
- Weak antasida ,slow ation and long action/duration
- Absorb protein and Fe from food ,Mg causes alkaliuri,can cause
siliceous nephrolithiasis
5.
B. Kloramfenikol
Come from Str. Venezuelae strong anti mikroba , inhibit protein syntetic with
interfere enzyme peptidil transferase. Bakteriosastik , can make anemia
Aplastik. Avaiable in palmintat dan stearat,kapsul 250 mg dan 500 mg.
good absorbsion in GET metabolism in hepar with conyugation acid
Glukoronat. Excretion pass ren
Side effect : 1. Concentration > 25 ug/ml deprsion bone narrow
Healing after drug stop
2. idiosinkrasi like anemiaplasik
3. Sindroma Gray if given in case neonatus premature
indication : salmonella typhi
Thiamphenicol : derivate Chloramphenicol
More safe than Kloramfenikol with out anemia apalstik
9. Hepatoprotektor dan regulator saluran cerna
Example : methionin, lecithine,curcumin as hepatoprotektor
Methionin is amino acid esensiale .make cholin.Cholin + gliserofosfat+ fatty acid
make lecithin one lipoprotein work as fat transport in blood
Efective as lipotropic
Regulator gastro intestinal
Metoclopramid
M.A