Dissolution: Dissolution Apparatus Overview 6 Dissolution Instrumentation 7

Dissolution
Dissolution Apparatus Overview
Dissolution Instrumentation
VK 7000 and VK 7010 Key Features
VK 7010 Dissolution Testing Apparatus
VK 7000 Dissolution Testing Apparatus
VK 7000 Small Volume Apparatus
7
8
10
14
17
VanKel Total Solution

VK 7000 / 7010 Single-bath Configurations
VK 7000 / 7010 Dual-bath Configurations
18
20
22
Dissolution Compatible Systems

Varian, Inc.
Agilent Technologies
Perkin Elmer Instruments
Waters Corporation
Carl Zeiss Jena GmbH
C Technologies, Inc.
Delphian Technology L.P.
Zymark Corporation
25
26
27
30
30
31
31
31
32
Dissolution Vessel Washing Stations
34
Dissolution Accessories
QAII Station
VK 5010 CLH Measurement System
Calibration Tools
Vessels
Paddles
Baskets
Capsule Weights
Manual Sampling Cannula Assembly
Cannula Filters
Resident Cannula Kits
Internal Dosage Delivery Module Retrofit
Temperature Controller
Motorized Sampling Manifold
Manual Sampling Bracket
Report Center II Retrofit Kit
Vessel Conversion Kits
Intrinsic Dissolution Apparatus
USP Apparatus 6 Rotating Cylinder
Suspension Cup
Paddle Over Disk Assembly
Transdermal Patch Holder System
Products for Release Rate Studies
36
36
38
39
41
47
50
55
56
57
59
60
61
62
62
62
63
65
65
66
66
66
67
VanKel manufactures USP dissolution apparatus 1, 2, 3, 5, 6 and 7. Please let us know how we can
be of assistance with specialized requirements.
USP APPARATUS 1
Rotating Basket
Standard 40-mesh basket.

Other mesh size baskets are available.
Special baskets of various design and sizes are available.
Volume ranges from 100 mL to 4L.
A variety of vessel sizes are available.
See pages 50 - 54.
USP APPARATUS 2
Paddle
Standard stainless steel paddle or Teflon-coated

stainless steel paddle.
Special Teflon and PEEK paddles are available.
A variety of vessel sizes are available.
See pages 47 - 49.
USP APPARATUS 3
Reciprocating Cylinder
Sequential operation for pH profiling.

300 mL outer tubes are standard.
See pages 70 - 71.
USP APPARATUS 5
Paddle over Disk
Standard stainless steel with disposable stainless screens.

Used for transdermal patches in a standard round bottom vessel.
Volume 900 mL.
See page 66.
USP APPARATUS 6
Rotating Cylinder
Two-piece assembly for testing transdermal patches using

Apparatus 1 and 2 dissolution testers.
Volume 900 mL.
See page 65.
USP APPARATUS 7
Reciprocating Holder
Utilizes sequential operation and a variety of dosage

holders.
Volume ranges from 20 mL to 275 mL.
Useful for transdermal patches, osmotic pump delivery
systems as well as other non-disintegrating dosage forms.
See pages 74 - 75.
VanKel Technology Group 13000 Weston Parkway Cary, North Carolina 27513-2228 USA
800.229.1108 919.677.1108 fax 919.677.1138 vankel_info@vankel.com www.vankel.com
VanKel is proud of our commitment to quality. Of the three standards after which companies can model their
quality system, VanKel complies with the most comprehensive, ISO 9001. This standard is a model for use by
both manufacturing and service organizations to certify their quality system from initial design and
development of a desired product or service through production, installation and servicing.
VanKel Quality Policy

VanKel is committed to designing and
manufacturing reliable products that exceed the
needs and expectations of our customers and to
deliver defect-free products and services on time
and at competitive prices. Every member of the
VanKel team is committed to rapid and continuous
improvement through well-documented and
customer-focused quality processes.
To achieve this policy the team shall:
conduct design, product quality and program

status reviews.
implement procedures to ensure quality in

marketing, design, procurement, product,
inspection, test and service.
operate an effective quality reporting and

corrective action system.
provide training programs relating to quality.
maintain the Quality System Manual, so as to

increase its usefulness as an aid in producing
quality products.
ensure the Quality Policy is understood,

implemented and maintained at all levels in the
organization.
VK 7000 AND VK 7010 KEY FEATURES
Reliable and robust

Unique time-saving features including
automatic start
1L, 2L and 4L Apparatus
Meets all current USP, JP and EP
requirements
The VK 7000 and VK 7010 models are designed

with automation and flexibility in mind. These
microprocessor-controlled instruments allow for easy
manual sampling and are designed to interface
directly with the VK 8000 Autosampling Station. The
EaseAlign system for centering vessels allows the
use of a variety of vessel sizes (with options of
100 mL, 200 mL, 500 mL, 1L (standard), 2L and 4L
vessels with Benchsaver models). These units are
preconfigured so they can accept accessory
upgrades. VK 7000 series units can be fitted with
AutoTemp and Dosage Delivery capabilities should
your testing needs change. As testing volumes grow,
you can modify your equipment; these models are
easily adapted to interface directly to a variety of UV
or LC systems or can be retrofitted into a Zymark
MultiDose system.
EaseAlign Centering Rings
Eliminate the need for tedious, time-consuming
vessel centering after each run. EaseAlign centering
rings allow the vessel to simply slide into place.
Once in place, your vessels do not floateven while
empty.
The EaseAlign rings center and align from the inside
of each vessel. This provides a simple, accurate
vessel-alignment process.
Display Information
The 4-line, 40-character LCD operational monitor
allows for a simple, easy-to-read display. During
operation the display includes time, date, elapsed
time, start time, set and actual RPM, set and actual
bath temperature, and printer status.
VK 7000 Options Display
Built-in Alarms
Both the VK 7000 and the VK 7010 have a variety of
built-in alarm features. You are warned of any
temperature deviations from the set parameters,
power outages, as well as the upcoming calibration
date.
VK 7010
Parameter Programming
A simple menu allows you to easily program your
parameters including:
delayed start
RPM (8 - 250 RPM)
length of test
temperature
infinity spin
Timed Wake-up
This unique feature automatically turns on the tester
and circulator at a predetermined time. This ensures
your bath is at the proper temperature without
operating the circulator continuously.
Elapsed Time Indicator
These testers offer an on-screen elapsed time
indicator. This indicator can be easily read from
across the room.
Spindle Motor Monitor

These testers report the number of spindle motor
hours that the instrument has been in use. This onscreen record allows you to schedule preventative
maintenance on actual operating hours rather than
arbitrary time periods.
Motorized Tester Drive Unit
VanKel pioneered the use of a motorized drive unit.
With the touch of a button, the motorized drive unit
on the VK 7000 / 7010 dissolution tester
electronically lowers to the proper position. When
the drive unit is down, you can automatically raise
the head. The motorized head ensures it returns to
precisely the same location.
Automated Sampling Manifold
One of the unique features of the VK 7000 / 7010 is
the ability to incorporate an automated sampling
manifold. At programmed intervals or by manual
control, the motorized sampling manifold provides
properly timed and precisely positioned sampling.
See the automated sampling manifold on page 10.
Chuck Assembly
Our unique chuck design assures the shaft is locked
in place. Once the height is set, there is no need to
worry about a change in alignment.
In addition, this system offers the flexibility of using
smaller diameter shafts and mini paddles for lowvolume dissolution testing.
Our type 316 stainless steel chuck offers rustresistant and wobble-free support for your shafts.
Should you prefer a different
design using O-rings with a locking
ringthis design can be
incorporated into either the
VK 7000 or VK 7010. This design
is preferred by some customers
who perform a number of
staggered basket starts. Contact
your VanKel representative for
more information.
Printer
Our built-in dot matrix printers
produce documents that can be
directly inserted into your laboratory
notebooks. Every VK 7000 / 7010
includes a built-in Report Center II
printer.
VK 750D Heater / Circulator
The external circulator provides
precise temperature control. Its
high throughput minimizes warm
up time. The external VK 750D
Heater / Circulator reduces
vibration and fits easily behind
the dissolution tester in order to
conserve valuable bench space.
VK 7000 / 7010
Printout
VK 750D
Molded Bath
This seamless bath was designed to warm all
vessels evenly by stabilizing the temperature
gradient. This design assures uniform temperature
control and makes cleaning easy.
The seamless water bath is molded from clear
PETG, a high performance polymer with more heat
and chemical stability than acrylic. The clear color
allows you to see the vessels through the water
bath.
To ensure the bath contains the appropriate amount
of water, there is a fill line for baths without vessels
as well as for baths with vessels in place.
Easy Drain
The easy access water bath drain spout allows for
quick and simple routine cleaning.
Locking Ring
Individual Spindle Control

Our easy-to-use clutch system makes dropping
tablets into non-rotating media per USP guidelines
effortless. The system provides a simple way to
perform manual staggered drops for Apparatus 2.
Just raise the clutch handle and the spindle is
disengaged. Push down the clutch handle to engage
the spindle.
Complete Operating System, No Post-purchase

Add-ons
When you purchase a VanKel dissolution tester,
VanKel provides you with an all-inclusive price
quote. This quote includes the price of the
equipment necessary to appropriately operate the
instrument. You receive your choice of baskets or
paddles, glass or plastic vessels, as well as
evaporation covers and all tubing and connectors.
For VK 7000 Dissolution Testers, see pages 14 - 17.
For VK 7010 Dissolution Testers, see pages 10 - 12.
10
VK 7010 DISSOLUTION TESTING APPARATUS
Preconfigured for automated analysis

Measures and records temperature in each
vessel
Programmable Dosage Delivery Module
automatically delivers dosage form into
vessel when used as Apparatus 2
Incorporates all VK 7000 system features (see
page 14)
requirements
Modularity
The VK 7010 allows for in-vessel temperature
monitoring at programmed time points and
automated delivery of the dosage form. These
automation building blocks combine to create an
extremely efficient stand-alone unit that can be
utilized in an in-line sampling or analysis system as
your testing demands increase. For example,
sampling can be easily added to the motorized
manifold, a standard feature on the VK 7010.
In-vessel Temperature Measurement
This motorized manifold automatically lowers,
collects temperature readings from each vessel, and
immediately raises at programmable intervals. Each
subsequent temperature reading repeats this
sequence precisely.
Automatic Temperature Measurement
The AutoTemp feature allows you to measure and
record temperature. It can be used to automatically
start a test after measuring the temperature in each
vessel to ensure they are stable and within limits.
Because the manifold raises between time points, it
eliminates the resident probe effect and maintains
correct hydrodynamics.
Dosage Delivery Module
The Dosage Delivery
Module allows you to be
elsewhere when the run
starts and drops occur with
far greater precision than
manual techniques allow.
This feature allows you to
program simultaneous or
sequential drops.
VK 7010 Automated Sampling Manifold
Pathway to Automation
Because the VK 7010 includes the internal hardware
necessary for automation, it can easily connect to an
automated sample collector, UV spectrophotometer,
LC instrument or Zymark's MultiDose systems. Your
VanKel technical sales representative can explain
these options.
Flexibility
Due to the numerous options available, this versatile
system can perform everything from simple manual
sample collection to complete sample automation.
A standard VK 7010 accepts several vessel volumes
including 100 mL, 200 mL, 500 mL and 1L vessels.
If these volumes do not satisfy your sink conditions,
an optional upgrade can be purchased which
accommodates 1L and 2L vessel volumes. See
page 12.
As with all VanKel products, we can tailor the
VK 7010 to address most customer requests.
Did
you
know?
Resident Probe Effect

The USP recommends that when employing
automated systems which alter the agitation
characteristics of the test, the equipment be
validated prior to use. The motorized sampling
manifold fully removes the cannula from the media
between time points in the same manner as
someone sampling manually. This reduces the
increased agitation associated with resident probes.
11
System Configurations
Each of the following configurations includes your

choice of glass or plastic vessels, paddles or baskets
and basket shafts. EaseAlign Centering Rings and
evaporation covers are included. The VK 750D is
standard.
VK 7010 Benchsaver
6-spindle, 6-vessel
The Benchsaver configuration saves laboratory bench
space. The vessel configuration consists of 2 rows of
3 vessels. The Benchsaver comes with 15-inch
paddles. For increased flexibility when sampling
manually, we recommend use of the 19-inch paddles
and extended height spacer PN 12-0321 (see page
39). This allows greater clearance to access the
middle position of the back row.
6-spindle VK 7010 Benchsaver Vessel Plate
Part Number
Specifications
Width: 54 cm
Depth: 56 cm
Height: 94 cm
Description
10-0100
VK 7010, 3+3, 115 V, 60 Hz
10-0200
VK 7010, 3+3, 230 V, 50 Hz
VK 7010 Easy Access

6-spindle, 8-vessel locations
This model provides "easy access" to the active
vessels around the perimeter of the bathfacilitating
manual sample collection. The 2 open positions
include covers to reduce bath water loss. These
open positions can be used with vessels (optional)
for media replacement. Should your needs change,
these 2 positions can be upgraded with spindles to
have an 8-spindle, 8-vessel configuration.
6-spindle VK 7010 Easy Access Vessel Plate
Part Number
Specifications
Width: 66 cm
Depth: 56 cm
Height: 94 cm
Description
10-0300
VK 7010, 4+2, 115 V, 60 Hz
10-0400
VK 7010, 4+2, 230 V, 50 Hz
VK 7010 Easy Access

8-spindle, 8-vessel
This configuration is ideal for customers interested in
automation. The VK 7010 Easy Access 8-spindle,
8-vessel tester includes 2 additional functioning
positions that can be used for any combination of
standards, controls and blanks.
8-spindle VK 7010 Easy Access Vessel Plate
Part Number
Specifications
Width: 66 cm
Depth: 56 cm
Height: 94 cm
Description
10-0700
VK 7010, 4+4, 115 V, 60 Hz
10-0800
VK 7010, 4+4, 230 V, 50 Hz
12
VK 7010 2L
The VK 7010 2L model is available in the Easy
Access (4+2 and 4+4) configuration. The 2L units
are configured the same as the 1L units except they
have a deeper water bath positioned under an
elevated base plate. The VK 7010 2L system can be
used with conventional 1L vessels or 2L vessels for
maximum flexibility.
System price includes:
6 2L vessels
6 1L vessels
6 19-inch paddles or rotating baskets and shafts
A 2L system is shown on page 16.
Specifications
Width: 66 cm (25.98 inches)
Depth: 56 cm (22.05 inches)
Height: 117 cm (46.06 inches)
Part Number
Description
VK 7010 equipped with a 2L bath

10-1935
Easy Access 4+2, 115 V, 60 Hz
10-1940
10-1950
10-1955
Did
you
know?
Sink Conditions
Defined as maintaining a volume of
dissolution media that is 5 to 10 times greater
than the volume at the saturation point of the
drug contained in the drug delivery
system being tested.
FREE with any purchasea Dissolution Calculation Diskette containing three Excel spreadsheets:
The Single Point Dissolution Calculation Spreadsheet calculates milligrams dissolved and
percent dissolved per dose for dissolution tests with a single time point.
The Replacement Media Dissolution Calculation Spreadsheet calculates milligrams
dissolved and percent dissolved per dose and corrects for analyte removed for up to 12
time points.
The Non-Replacement Media Dissolution Calculation Spreadsheet calculates milligrams
dissolved and percent dissolved per dose correcting for non-replacement media and
analyte removed at up to 12 time points.
Use these spreadsheets to quickly and easily make calculations and reduce mathematical errors
in your analysis. Yours free with any purchase! Please request PN 77-2000. The calculation spreadsheets
are also available for download at www.vankel.com.
VanKel is always working to develop new technology.

Visit the VanKel Web site at www.vankel.com for our latest
innovative new products.
VanKel strives to provide quality products and effective service to our customers. VanKels Laboratory
Services department provides technical support and assistance to clients throughout the pharmaceutical
industry. We offer educational services, live training and conferencing through our interactive video system,
timely and accurate answers to your questions through our hotline and much more. Call 800.229.1108 or visit
our Web site at www.vankel.com to find out more about all the ways VanKel wants to meet your needs.
13
14
VK 7000 DISSOLUTION TESTING APPARATUS
Microprocessor-controlled dissolution testing

Modular design for future upgradability
requirements
Same platform as the VK 7010
Preconfigured to accept system upgrades
These microprocessor-controlled units offer

tremendous flexibility. The EaseAlign system for
centering vessels allows the use of a variety of
vessel sizes (with options of 100 mL, 200 mL,
500 mL, 1L (standard), 2L and 4L vessels with
Benchsaver models).
The built-in Report Center II dot matrix printer
provides you with a permanent record of the time of
day, elapsed time, RPM and bath temperature.
To review the many other standard features of the
VK 7000, see pages 8 and 9.
Cost-effective Alternative
This cost-effective dissolution tester will not restrict
future productivity enhancements. With the
appropriate accessories it can be upgraded to an
online UV, LC or fully automated system.
System Upgrades
The following upgrades can be added easily to the
VK 7000 as your needs change:
Dosage Delivery Module (DDM)The DDM
can be programmed to drop tablets into nonrotating media simultaneously or sequentially.
See page 60.
AutoTempAutoTemp measures and records
in-vessel temperature at designated time points.
It can also be used to initiate a run when the
vessel temperatures have stabilized. See page
61.
Manual Sampling
with Luer Lock-type Cannula
VK 7010
Did
you
know?
VanKel offers a manual

sampling manifold which raises and lowers the
sampling cannulas and can be used with
the manual sampling bracket on the
VK 7000 or the VK 7010 (see page 62).
Motorized Sampling ManifoldThere are two

methods for pulling samples using the motorized
VanKel Sampling Manifold. The manual
sampling bracket in conjunction with the
motorized manifold facilitates the raising and
lowering of the sampling cannula to ensure the
correct USP sampling location. The automatic
sampling manifold used in conjunction with the
VK 8000 allows the entire sampling process to
be performed automatically. See page 62.
Manual Sampling Bracket

with Luer Fittings
15
Each of the following configurations includes your choice

of glass or plastic vessels, paddles or baskets and basket
shafts. EaseAlign Centering Rings and evaporation covers
are included. The VK 750D is standard.
VK 7000 Benchsaver
6-spindle, 6-vessel
The Benchsaver configuration saves laboratory bench
space. The vessel configuration consists of 2 rows of
3 vessels. The Benchsaver comes with 15-inch
paddles. For increased flexibility when sampling
manually, we recommend use of the 19-inch paddles
and extended height spacer PN 12-0321 (see page
39). This allows greater clearance to access the
middle position of the back row.
Part Number
Specifications
Width: 54 cm
Depth: 56 cm
Height: 94 cm
Description
10-1000
VK 7000, 3+3, 115 V, 60 Hz
10-1100
VK 7000, 3+3, 230 V, 50 Hz
VK 7000 Easy Access

6-spindle, 8-vessel locations
This model provides "easy access" to the active
vessels. All of the spindle locations are on the
outside of the base plate around the perimeter
facilitating manual sample collection. The 2 open
positions come with covers to reduce evaporative
loss. These open positions can be used with vessels
(optional) for media replacement. Should your needs
change, these 2 positions can be upgraded with
spindles to have an 8-spindle, 8-vessel configuration.
S
S
Part Number
Specifications
Width: 66 cm
Depth: 56 cm
Height: 94 cm
Description
10-1200
VK 7000, 4+2, 115 V, 60 Hz
10-1300
VK 7000, 4+2, 230 V, 50 Hz
VK 7000 Easy Access

8-spindle, 8-vessel
This configuration is ideal for automation. The
VK 7000 Easy Access 8-spindle, 8-vessel tester has
2 additional functioning positions that can be used for
any combination of standards, controls and blanks.
Specifications
Width: 66 cm
Depth: 56 cm
Height: 94 cm
Description
10-1600
VK 7000, 4+4, 115 V, 60 Hz
10-1700
VK 7000, 4+4, 230 V, 50 Hz
Part Number
16
VK 7000 2L
VK 7000 2L models are available in both Benchsaver
(3+3) and Easy Access (4+2 and 4+4) configurations.
The 2L units use the same configuration as the 1L
units except they have a deeper water bath
positioned under an elevated base plate. The
VK 7000 2L system can be used with conventional 1L
vessels or 2L vessels for maximum flexibility.
6 2L vessels
6 1L vessels
Specifications
Benchsaver
Width: 54 cm
Depth: 56 cm
Easy Access
Width: 66 cm
Depth: 56 cm
Height: 117 cm
VK 7000 2L unit with
1L vessels
Height: 117 cm
Part Number
Description
VK 7000 equipped with a 2L bath
10-1810
Benchsaver 3+3, 115 V, 60 Hz
10-1910
10-1800
10-1900
10-1920
10-1930

VK 7000 2L unit with
2L vessels
VK 7000 4L
Maximize the utility of your dissolution bath
VK 7000 4L units are available in the
Benchsaver configuration only. When the
Benchsaver model is configured for 4L
vessels, only three spindles can be used.
The VK 7000 is offered in an easily
S
convertible format allowing you to use 4L,
2L and 1L vessels. By changing the vessel
plate insert you can switch from three 4L vessels to
six 2L or six 1L vessels. This option offers you the
greatest flexibility when dealing with sink conditions.
6 1L vessels
3 4L vessels
S
S
VK 7000 4L unit
Part Number
Description
VK 7000 convertible
Specifications
Width: 54 cm
Depth: 56 cm
Height: 117 cm
10-5300
4L / 1L, 115 V, 60 Hz
10-5400
4L / 1L, 230 V, 50 Hz
17
Use with mini paddles and mini

baskets
Use with the Enhancer Cell for
topicals, creams and ointments
(see page 67)
Requires few accessories to
operate
VK 7000 SMALL VOLUME APPARATUS
This specially configured VK 7000 will accept 12

vessels (either 100 or 200 mL) along with VanKels
mini paddle or mini basket shafts. You get all the
same programming features of the VK 7000 (see
pages 8 and 9 for details).
Although designed for use with Enhancer Cells, this
system is also used when special, smaller volumes
are required. Flat- or round-bottom vessels are
available. Additionally, both mini paddles and mini
baskets are designed for this system.
Drug Release Testing for Topical Treatments
The VK 7000 small volume system solves the
dissolution testing dilemma associated with creams,
ointments or other topical treatment. This system
uses the tested Paddle over Enhancer Cell
Apparatus. See page 67 for the Enhancer Cell.
Perfect Enhancer Cell Centering
Our specially designed 200 mL flat-bottom, selfaligning glass vessels perfectly align your Enhancer
Cell in the vessel. A consistent placement of the
Enhancer Cell provides you with reliable and
reproducible results. See page 67 for the Enhancer
Cell.
Run Multiple Lots Simultaneously
The 12-vessel, 12-paddle configuration allows you to
operate two 6-vessel runs simultaneously. Each run
is conducted under the same method,
instrumentation and physical environment.
Can Also be Used with New
Mini Baskets!
A newly designed mini basket
fits on a special Dura-Fit
basket shaft. See page 54 for
details.
Vessel, Mini Paddle

and Enhancer Cell
System Configuration
12-spindle, 12-vessel
This alternative requires few accessories to operate
and produces reliable, reproducible results.
12 Glass vessels (specify 100 or 200 mL, roundbottom or flat-bottom)
12 Teflon-coated mini paddles (standard)
Note the Enhancer Cells must be ordered separately
(see page 67).
Specifications
Width: 66 cm (25.95 inches)
Depth: 56 cm (22.05 inches)
Height: 94 cm (37 inches)
Mini Basket and

Dura-Fit Basket Shaft
Part Number
Description

10-5000
6+6, 115 V, 60 Hz
10-5100
6+6, 230 V, 50 Hz
Total Solution
Total Solution
18
Dual-bath Total Solution
TOTAL SOLUTION
Complete UV automation package

IQ OQ PQ available for the system
Automatic start (including dosage drop)
Easy testing, validation and reporting
requirements
The VanKel and Varian Team

VanKel and Varian have combined forces to provide
you with one of the most innovative and flexible
tablet dissolution systems on the market. This
system provides you with a simple automated
dissolution testing system using UV-VIS analysis.
When you order from VanKel, you have one vendor
to handle your training as well as any questions that
may arise.
Flow-through Sample Collection

The Cary 50 utilizes an 18-position multicell
transport. The flow-through design maintains a
constant volume in the vessels throughout the entire
run by returning the solution back into the vessels,
eliminating the need to calculate for volume lost.
Cross-contamination between samples cannot occur
as each vessel has a dedicated flow cell.
Variable Data Collection Rate
You can specify multiple regions in the run, each of
which has a different data collection rate. This allows
you to collect more data when the absorbance is
changing quickly and to have fewer data points in
the more stable parts of the dissolution profile.
Complete Dissolution System

The Total Solution system includes a computer,
monitor, printer, Cary 50 Spectrophotometer and
your choice of VanKel dissolution tester. The Total
Solution is available in single- or dual-bath
configurations.
Secure Data Collection

Unlike more conventional systems that store data
only at the end of a run, the VanKel Total Solution
stores data as it is acquired. Because data is being
continually saved, even in the event of a power
outage, your data to that point is secure.
Self-operating System
The software allows you to pre-program a start time.
When used in conjunction with the VK 7010, paddle
methods can be started automatically.
Reporting Solution
A comprehensive report can be tailored for your
specific reporting needs. Graphics showing time
versus percent dissolved, time versus milligrams
dissolved, and time versus absorbance can be
included in a report, with each vessel indicated by a
different color trace. Your dissolution reports can
include your company logo or any bitmap you
choose.
Measures Samples with High Background

Correction
You can measure highly absorbing samples without
dilution. The extended photometric range of the Cary
instrument allows you to measure samples requiring
high background correction that would normally
require HPLC analysis.
Audit trails are logged providing information about

how the data was collected and calculated.
GLP Compliance
GLP application is used to set up different privileges
for the users in your laboratory and to comply with
Good Laboratory Practice.
21 CFR Part 11 Compliance
VanKel and Varian are committed to providing a
system meeting this regulatory requirement. For an
update on the current system, please check the
Varian Web site at www.varianinc.com.
Cary 50 Spectrophotometer
The Cary 50 Xenon lamp allows 80
data points per second.
The Xenon lamp flashes only when
acquiring a data point, unlike a diode
array which exposes the sample to the
whole wavelength range with each
reading, causing degradation of
photosensitive samples.
System Qualification
VanKel offers a complete
qualification guide of the
entire system
(spectrophotometer,
dissolution tester and
dissolution protocols).
This guide is available to you as is the qualification
service by one of our laboratory chemists. VanKel
can perform the qualification of the complete system
for you. Order PN 11-1130 for the qualification guide
or call for details about our service capabilities.
Cary 50
Spectrophotometer
The Cary 50 is unaffected by room light. It can be

operated with the sample compartment opened or
closed.
The 18-position multicell transport easily handles
either 1 or 2 dissolution baths. Because each vessel
has its own flow cell, there is no cross-contamination.
VanKel Qualification Guide
Software Components
Cary Win UV software version 2.02 is supported
by Windows 95, Windows 98 and Windows NT.
Version 2.10 (141) is supported by Windows 95,
Windows 98, Windows NT and Windows 2000.
Software applications allow you to:
Create and store custom methods, which include

equipment parameters.
Create multistandard calibration curves or import
equations for your dissolution runs.
Perform routine wavelength scanning
measurements.
Measure the photometric value of samples at
fixed wavelengths.
Export data as an ASCII file for further data
manipulation.
19
Total Solution
Total Solution
Total Solution
20
Total Solution
VK 7000 / 7010 Single-bath
Configurations
The Total Solution System can be set up with the
VK 7000 as USP Apparatus 1 or 2 and can be
configured with either 1 or 2 dissolution testers (see
page 22).
The automated sampling manifold automatically
raises and lowers sampling cannulas unattended for
ultimate positioning control and perfect
hydrodynamics. When the Total Solution is paired
with the VK 7010, our Dosage Delivery Module
allows you to preload and drop dosage units at a
prescribed time or temperature for time-saving,
automatic, unattended operation.
A complete system consists of 3 components: the
UV package (PN 11-1100 or 11-1120), flow cells
meeting your pathlength requirements and a VanKel
dissolution tester (either the VK 7010 or VK 7000).
VK 7010
Single-bath Total Solution
VK 7000
Part Number
Description
Part Number
Description
VK 7010 (4+4) Single-bath for use with Total Solution.

Includes custom manifold, 200 mL conversion kit,
Peristaltic Pump and tubing.
VK 7000 (4+4) Single-bath for use with Total Solution.

11-1200
VK 7010 with paddles, 115 V, 60 Hz
10-6920
11-1205
VK 7010 with baskets, 115 V, 60 Hz
10-6930
11-1210
10-7032
11-1215
10-7022
Did
you
know?
VanKel qualification documents are available

for purchase (see page138). VanKel chemists are
available to perform installation, operation and
performance qualifications on
your equipment.
Total Solution
21
Total Solution
Total Solution Single-bath Configuration

Media Flow Diagram
Total Solution
22
Total Solution
VK 7000 / 7010 Dual-bath
Configurations
The Total Solution System is also available in dualbath configurations. This system allows you to run
two baths with the same method at the same time.
A complete system consists of 3 components: the
UV package (PN 11-1100 or 11-1120), flow cells
meeting your pathlength requirements and 2 VanKel
dissolution testers (either the VK 7010 or VK 7000).
Total Solution Screen Display
VK 7010
VK 7000
Two VK 7010 baths can be integrated into a single

UV-VIS system. Both testers are configured in the
same manner including a built-in Dosage Delivery
Module and AutoTemp for in-vessel temperature
monitoring.
In this configuration, 2 VK 7000s are linked to 1

Cary 50 UV. Each bath is identical in their setup,
method and start time. Dedicated lines and UV cells
ensure no cross-contamination between vessels,
standards or blanks.
Part Number
Part Number
Description
VK 7010 (4+4) Dual-bath for use with Total Solution.

Description
VK 7000 (4+4) Dual-bath for use with Total Solution.

11-1220
2 VK 7010s with paddles, 115 V, 60 Hz
10-6925
11-1225
2 VK 7010s with baskets, 115 V, 60 Hz
10-6935
11-1230
10-7035
11-1235
10-7025
Single-bath Total Solution

Total Solution
23
Total Solution
Total Solution Dual-bath Configuration

Media Flow Diagram
24
Total Solution
Total Solution
The Cary 50 UV-VIS Spectrophotometer

The Power of Xenon
The Cary 50 uses a Xenon flash lamp which flashes
only when acquiring a data point, rather than
exposing the sample to the whole wavelength range
at each reading. This minimizes degradation of
photosensitive samples.
The Xenon lamp has a long life expectancy so you
wont be changing bulbs very oftenif at all.
The Xenon lamp allows the Cary 50 to use a beam
splitter for simultaneous reference beam correction
without the loss of energy, which causes excessive
photometric noise. In addition the peaks will not shift
as the scan speed changes.
Fast, Effective and Flexible
You can scan the entire wavelength range from 1901100 nm in less than 3 seconds.
The Cary 50 can measure samples up to 3.0 Abs.,
decreasing the need for dilution.
The Cary 50 is unaffected by room light. Operate
with the sample compartment open or closed; there
is no difference.
System Qualification
VanKel offers a complete qualification guide for the
entire system (spectrophotometer, dissolution tester
and dissolution protocols). This guide is available to
you as is the qualification service by one of our
laboratory chemists.
VanKel can perform the
qualification of the
complete system. Order
PN 70-4960 for the
qualification guide or call
for details about our
service capabilities.
Cary 50 UV-VIS Spectrophotometer
Dual Cell Tubing Kit

The Cary 50 makes it easy
to interconnect two different
cells within the 18-position
multicell transport. This
allows you to switch
between two sets of cells
(typically with different
Dual Cell Tubing Kit
pathlengths) with no
disassembling or re-assembling of the tubing lines.
Switching between methods requiring cells of
different pathlengths is as easy as selecting the cells
to be read using the Total Solution software. Only
one tester can be used when the dual cell tubing is
in place.
Part Number
11-1320
Description
Dual Cell Tubing Kit, dual pathlength
VanKel Qualification Guide
For more information call your VanKel

representative.
Part Number
Description
Quartz Flow Cells
11-1000
Cary 50 UV-VIS Spectrophotometer,

115 V or 230 V (requires PC to operate
and card and cable to connect PC and
Spectrophotometer)
Part Number
Flow cells are specially designed for the VanKel

Total Solution System Cary 50. Smaller pathlengths
are available. Call VanKel for details.
Description
11-1030
Cary 50 Card and Cable
11-1300
Flow Cell 1.0 cm for Cary 50 serialized
11-1050
Cary Win UV Dissolution Software
11-1305
Extended Sample Compartment
11-1310
11-1015
Sample Compartment Tubing Coupler
11-1315
11-1020
Eighteen-cell Multitransport
11-1320
Dual Cell Tubing Kit, dual pathlength
11-1035
Cable Kitfor connecting either

one or two VanKel baths
11-1325
Tubing Kit, replaces tubing between

Peristaltic Pump and flow cells
11-1010
Total Solution
25
If you already have a VK 7000 or VK 7010 bath, you can integrate your existing equipment. Depending on the
configuration of your existing equipment, you may need an automated sampling manifold with the internal
motor drive along with the appropriate Peristaltic Pump. Call for more details. To simplify the ordering
procedure, we have created the following packages (flow cells are not includedsee page 24):
Package 11-1100
1 Cary 50 UV-VIS Spectrophotometer
1 Extended cell compartment
1 Sample compartment tubing coupler
1 18-position cell holder
1 Cary 50 accessory card and cable kit
1 Cary Win UV dissolution software
1 Dell Pentium-based PC with monitor
1 HP color printer
Package 11-1105
1 Cary 50 UV-VIS Spectrophotometer
1 Extended cell compartment
1 Sample compartment tubing coupler
1 18-position cell holder
1 Cary 50 accessory card and cable kit
1 Cary Win UV dissolution software
Part Number
Part Number
Description
VanKel Total Solution Upgrade Cary 50 UV package

11-1100
Cary 50 UV Package 115 V, 60 Hz
11-1120
Cary 50 UV Package 230 V, 50 Hz
Description
VanKel Total Solution Upgrade Cary 50 UV package

without PC, monitor and printer
11-1105
Cary 50 UV Package 115 V / 230 V
Dosage Delivery Modules are available for the VK 7000 and are compatible with Cary 50 upgrades.
See page 60 for details.
Varian Fiber Optic Dip Probe

To extend the utility of your Cary 50, we offer as an
accessory a fiber optic dip probe.
Varians fiber optic dip probe is a trouble-free
alternative to a conventional sipper. Measurements
can be taken directly from a vessel. There is no
need to transfer samples to an instrument cuvette or
to pump samples into flow cells. No more bubbles in
the flow cell blocking the light beam and destroying
your measurement. The fiber optic dip probe does
not use tubing or any metallic componentsorganic
or corrosive solutions can be measured with ease.
No more tubing leaks and degradation.
Part Number
11-1130
Description
Varian Fiber Optic Probe
Varian Fiber Optic Dip Probe
Total Solution
Total Solution Upgrade

for Your Existing Apparatus
26
AUTOMATED COMPATIBLE SYSTEMS

VanKel dissolution testers are ideal for use in automated systems. There are a number of analytical instrument
systems designed for use with VanKel testers. The following list of companies is a representative sample of
companies whose products are compatible with VanKels products and is not intended to be an explicit or
implied endorsement, sponsorship or other association by these companies with VanKel or its affiliated
businesses. Among these are:
UV-VIS Spectroscopy
Fiber Optic Spectroscopy
Varian, Inc.
Agilent Technologies (formerly Hewlett Packard)
Liquid Chromatography
Varian, Inc.
Waters Corporation
Shimadzu
Thermo Separations Products
VanKel testers can be integrated to almost any LC

equipment using the VK 8020 Autosampler /
Auto-Injector (see page 105).

Leap Technology
Varian, Inc.
Fully Automated
Zymark Corporation
To learn how to best integrate your analytical
instruments with your VanKel dissolution tester, call
800.229.1108 or contact your local VanKel
representative.
Varian, Inc.
Varian incorporates VK 7000 and VK 7010 baths into
their UV analysis systems. These systems incorporate
either the Cary 50 (see pages 18 - 25) or the Cary 100,
300, 400 and 500 model spectrophotometer. No matter
what your spectral demands are, VanKel has an
automated system that can work for you.
VK 7000 with External DDM connected to a Cary UV Spectrophotometer

27
Agilents ChemStation dissolution software

interfaces with the VK 7000 and VK 7010 baths.
VanKel provides the drivers to communicate with
the HP 8453 Diode Array Spectrophotometer,
ChemStation software (including the dissolution
module) and an 8-position cell changer. You can
easily incorporate an existing VanKel bath to the
ChemStation software utilizing VanKel UV interface
kits (see below). Both single- and multibath
systems are available. Contact us for drivers to
control your VanKel bath. For more information,
contact your VanKel representative.
These devices control both the Agilent Peristaltic
Pump as well as the VanKel bi-directional pump.
Using the VanKel pump allows the back-flushing of
filters.
The VanKel drivers allow for the maximum use of
the VanKel baths. You can control the motorized
manifold, in-vessel temperature measurement as
well as the dosage delivery mechanism (ideal for
staggered starts).
Agilent HP 8453 Spectrophotometer with VK 7000-series Dissolution Tester
Part Number
Description
11-0010
Software drivers for single-bath

configuration. Includes driver qualification
guide and cables for use with HP 8453
Spectrophotometer.
11-0011
Software drivers for multibath configuration.

Includes driver qualification guide and
cables for use with HP 8453
Spectrophotometer.
28
Agilent Single-bath Configuration

Media Flow Diagram
29
Agilent Multibath Configuration

Media Flow Diagram
30

Perkin Elmer Dissolution Lab software works with
VanKel testers in conjunction with their Lambda
Series Spectrometers. The software automates both
online and offline tablet dissolution studies.
Dissolution Lab software includes password security
and provides two levels of access: supervisor and
user. Additional security features include binary
storage of data files for manual verification of results,
if needed. All report printouts include footnotes with
date, time and consecutive page numbers.
Waters Corporation
The VK 7000 and 7010 are fully compatible with the
Waters Alliance System for automated sampling
using programming capabilities built into VanKel
testers. Unlike other testers, VanKel testers do not
require the use of resident dwelling probes. All
operating parameters can be initiated by the transfer
station, including the dropping of tablets and
recording individual vessel temperature
measurements and sampling time points
(dosage dropping and vessel temperature
measurement are standard features of the
VK 7010). The Alliance System, with
Millennium software, allows two testers to
be connected to one LC. To accommodate
the Waters sampling probes, we offer
customized sampling manifolds. These can
be fitted to any VK 7000 or VK 7010.
Using a VK 7010, you can automate the
start of the test (measuring and recording
the temperature) as well as dropping the
dosage form when used with paddles.
Waters Alliance System with VK 7000-series Dissolution Testers
Note that
tubing and sampling cannulas are supplied by
Waters.
manifolds require the use of a motorized drive.
Your tester may or may not have this already
installed.
Please call your VanKel representative if you have
questions.
Part Number
Description
Customized Waters Manifold

17-3130
For Benchsaver testers (3+3

configuration)
17-3132
For Easy Access models (4+2, 4+3 or

4+4 configurations)
31
The Zeiss Optical Dissolution In-situ

Analysis and Control system, known as the
ZodiaC, is a new development which uses
multiple fiber optic probes for multichannel
analysis with the proven MCS
spectrophotometer coupled to an 8-channel
multiplexer. Initially targeted for sustained
release products with dissolution profiles of
24 - 48 hours, the system can also be used
for fast-release products. The system can measure
time points down to a minimum of 1 minute due to
the use of a fast and precise multiplexer. The fiber
optic probes are mounted on a special manifold and
positioned for the correct height and distance from
the vessel walls to comply with USP.
Zeiss ZodiaC with VK 7010
The Cassini multiplexer is an input-output multiplexer
which allows multiple fiber optic probes to be used
with a single Cary 50 spectrophotometer. This
device allows software-controlled switching of the
fibers coupled to the light source and detector of the
spectrophotometer. These probes easily attach to
VanKels manifold for fiber optic dissolution testing.
C Technologies Cassini Multiplexer and Cary 50 with VK 7010

The new Rainbow Dynamic Dissolution Monitor
system can be used with one or more VanKel
dissolution testers. This system gives you complete,
calculated results in real-timeincluding GMPcompliant printouts for a fiber-optic methodology of
dissolution testing accepted by the FDA. It is ideal
for analyzing both immediate- and extended-release
oral forms. As your sample dissolves, fiber-optic
probes deliver a continuous stream of dissolution
datadata displays every ten seconds. Set-up and
suitability testing are quick and easy, and there is no
sampling, no transfer and no post-run calculations.
Delphian Rainbow Dynamic Dissolution Monitor System
32

ZYMARK CORPORATION
Zymark MultiDose
Zymark has developed an advanced workstation for
fully automated USP II dissolution testing. The
MultiDose Automated Dissolution Workstation runs
up to 8 batches (48 samples) without intervention,
using the same method or different methods. The
system can perform single-point dissolution tests or
multiple point dissolution profiles. All activities of the
system are documented in an electronic audit trail.
The system is fully USP compliant. The MultiDose
performs a typical automated dissolution sequence
in the following way:
preheat and degas the media
dispense the requested volume of media into
each vessel with gravimetric confirmation
verify and record the temperature in all six
vessels
automatically introduce the dosage form to start
the test
remove and filter samples at prescribed time
interval(s)
replace the volume of media removed at users
option
perform online UV measurements or collect
fractions
empty vessels, then wash them in place
start again until all methods have been executed
The MultiDose is fully validated upon installation; IQ,
OQ and PQ protocols executed and final report
generated. Also, the new MultiDose G3 software
package now makes the unit fully 21 CFR Part 11
compliant.
Specifications
Height: 101.6 cm (40 in.)
Recommended bench space: 60.96 cm (23.99 in.)
(not including space for PC controller, dissolution
tester or sample output devices, such as fraction
collector or UV-VIS spectrophotometer)
Part Number
Description
VK 7000s for use with the MultiDose

10-6000
VK 7000 Benchsaver 3+3, 115 V, 60 Hz
10-6200
VK 7000 Benchsaver 3+3, 230 V, 50 Hz
10-6400
VK 7000 Easy Access 4+2, 115 V,

60 Hz
10-6600

50 Hz
10-6615

60 Hz
10-6620

50 Hz
Zymark MultiDose with VK 7000-series Dissolution Tester

33
The MultiDose Plus, in conjunction with an

"automation ready" VK 7000 dissolution tester, can
run up to eight batches of samples unattended. The
system preheats and conditions the dissolution
media, fills each vessel with the appropriate volume
of media, verifies temperature, starts the dissolution
test, removes sample aliquots at the user-defined
time intervals, then empties and cleans each vessel
before starting another run. When configured for
Apparatus 1, the system removes the spent basket
and replaces it with a new basket containing the
dosage form for the next analysis. When configured
for Apparatus 2 with capsule sinkers, the system is
capable of retrieving the sinker at the end of the run.
The system can also act as a standard MultiDose
System for ordinary Apparatus 2 dissolution tests.
Dissolution samples are either stored for offline
analysis or can be analyzed online with an
appropriate multicell UV-VIS Spectrophotometer. All
operations of the system are documented in an
electronic audit trail.
The new MultiDose Plus G3 software package now
makes the unit fully 21 CFR Part 11 compliant.
Specifications
Height: 101.6 cm (40 inches)
Recommended bench space
Linear array: 210.82 cm (83 inches)
Non-linear arrangement: 144.78 cm (57 inches)
(not including space for PC controller, dissolution
tester or sample output devices, such as fraction
collector or UV-VIS spectrophotometer)
Part Number
Description
VK 7000s for use with the MultiDose Plus

10-6800

60 Hz
10-6810

50 Hz
Zymark MultiDose Plus with VK 7000-series Dissolution Tester
Zymark MultiDose Plus
34

VK 900 MOBILE WASHING STATIONS
NEW
Dissolution Vessel Washing Station
Clean vessels in place!
Designed to clean 1L vessels

Quickly and efficiently cleans vessels in place
Fits securely over any standard 1L vessel
Reduces risk of damage to vessels
Evacuate, Rinse, Repeat

The VK 900 Washing Station pressure washes the
vessel with three washing cycles. The VK 900s
washing ball uses a revolving action and high
pressure stream to wash the interior of your vessels.
In less than five minutes your tester is ready for the
next test.
With one filling of the rinse tank you can clean up to
32 1L vessels before a changeover is required.
Easy to Fill, Easy to Empty
The quick-disconnect fitting on the top of the
washing station makes filling the rinse tank as easy
as turning on a water faucet. The rinse tank is
equipped with an inlet valve and float device to
prevent overfilling. An LED illuminates to indicate the
tank is full.
An antifoaming agent can be added to the waste
tank to minimize foaming when evacuating media
containing surfactants.
The built-in vacuum pump easily evacuates the
waste tank. Neutralizing agents can be added to the
waste tank prior to disposal.
Saves Time
When you remove vessels for washing, you should
always reverify the centering and height
parameters. Cleaning the vessels in place
preserves set parameters and eliminates the timeconsuming step of reverification from future tests.
VK 900 Washing Station
Did
you
know?
Carry-over studies should be performed on

automated equipment to ensure proper cleaning
between collection and analysis of samples.
Carry-over can affect the sample reading possibly
causing erroneous results.
One Station Fits All

The VK 900 is compatible with most dissolution
testers. The aspiration tube can be configured to
remove spent media from any 1L vessel. The
cleaning head fits securely over any standard
vessel.
Mobile
The VK 900 is a cleaning, containment and disposal
unit all in one mobile housing. The durable casters
smoothly roll the unit directly to your dissolution
tester.
VK 900 In Use
35

The VK 900 is a fully mobile, self-contained washing
station that cleans your vessels quickly and
efficiently.
Specifications
Length: 81.28 cm (32 inches)
Width: 45.72 cm (18 inches)
Part Number
VK 900 Washing Station with Heater

Option
Heats cleaning fluid for better washing efficiency.
The heater option keeps your cleaning fluids heated
up to 50 C.
Specifications
Length: 81.28 cm (32 inches)
Width: 45.72 cm (18 inches)
Description
VK 900
Part Number
11-5000
Mobile Washing Station, 115 V, 60 Hz
11-5010
Description
VK 900 with heater

11-5020
11-5025
Part Number
Description
VK 900 Replacement Parts
Evacuation Stage
11-5200
2-inch VK 900 Cleaning Head Tubing
11-5210
6-inch VK 900 Cleaning Head Tubing
11-5215
VK 900 Rinse Tank Fill Hose
11-5220
VK 900 Rinse / Waste Tank Drain Hose
11-5225
500 mL VK 900 Rinse Tube
Did
you
know?
Rinse Stage
When evacuating media where a surfactant

has been used, an antifoaming agent should
be added to the VK 900 to keep foaming
to a minimum.
Wash Complete
Dissolution Vessel Washing Station
36
QAII STATION
Patent 6,155,113
Effective Measurement System

The QAII allows you to measure and record
dissolution physical parameters (as specified in USP,
EP and JP). It easily measures and documents
individual spindle speeds, shaft wobble, shaft
perpendicularity, temperature and instrument level.
In addition, the QAII measures vibration. The
vibration display shows vibration is a function of four
different parameters (acceleration, velocity,
frequency and displacement) in all three axes X, Y
and Z.
The QAII can be used on almost all brands of
dissolution testers. An adapter ring for non-VanKel
testers is included.
E
B
D
C
NIST-traceable Results
A calibration certificate is included.
Truly Portable
The QAII is battery operated as well as
line-operable. The printer is only operated when the
instrument is plugged into a wall socket to conserve
battery life.
Information Storage
The QAII stores information for up to 30 testers and
retains the serial numbers by unit and each
individual shaft ID.
Digital Wobble Gauge
Vibration Sensor
The easy-to-use menu prompts you through the

step-by-step process. You have the option of
skipping various positions or measurements.
Station includes the following, as pictured above:
Digital wobble gauge, mounted to an EaseAlign
mounting bracket (A)
Magnetic tachometer sensor (B)
Black reflection clip with magnetic tag (C)
Electronic level sensor (also measures shaft
perpendicularity) (D)
Precision temperature probe (E)
Electronic vibration sensor (F)
Universal adapter for use with
non-VanKel units (G)
Calibrated shaft (not shown)
Part Number
Description
12-0520
QAII Station 115 V, 60 Hz
12-0530
QAII Station 230 V, 50 Hz
12-0531
Carrying Case
QAII Printout
37
QA and QAII Station Replacement Parts

If you have an earlier model QA Station, contact
VanKel for part replacement information.
Description
12-9005
Universal Adapter for QAII Station

(for non-VanKel instruments)
12-9006
Adapter, 4L vessels
12-9010
Calibration Shaft
12-9015
RPM Sensor Reflective Clip, black
12-9020
RPM Sensor Reflective Clip, white
12-9021
Magnetic RPM Sensor for 1/4-inch shaft
12-9025
Magnetic RPM Sensor for 3/8-inch shaft
12-9995
Plain Paper for Report Center II printer

for QAII, package of 10 rolls
12-9996
Plain Paper for Report Center II printer

for QAII, package of 100 rolls
12-9997
Ribbon Cartridge for Report Center II

printer for QAII, package of 5
12-9999
Thermal Paper for Report Center I

printer for QA, package of 10 rolls
12-9994
Thermal Paper for Report Center I

printer for QA, package of 100 rolls
12-0531
Carrying Case for QAIIhard

plastic case with foam support inside
NIST-traceable Re-certification of
QAII Station
VanKel will re-certify your QAII Station. Call our
Technical Service Department for packing
instructions and Return Authorization Number (for
tracking purposes) before returning your instrument.
Equipment should be shipped in the original
packaging to prevent damage during shipping.
NIST-traceable items include the wobble gauge,
temperature probe and the tachometer sensor.
If you have an original QA Station, contact VanKel
for calibration information.
Part Number
75-7500
Description
Part Number
Protect your investment by shipping your QAII in this

hard plastic carrying case.
QAII Upgrade
The QA Station with optical reflective chips can be
upgraded to use the new magnetic tachometer
sensor and chip. Call VanKel for details!
Part Number
12-7505
Description
QAII Sensor Upgrade (magnetic)
Return your QA Station to

VanKel for re-calibration!
Call our Technical Service Department to have your
QA Station re-calibrated. Your calibration will be
expedited and your instrument will be back in
service in a very short time.
NIST Re-certification of QAII Station
38
VK 5010 CLH MEASUREMENT SYSTEM
Patent Pending
Provides absolute readings for shaft

centering and paddle or basket height
measuring
Improves accuracy over manual gauges
Takes digital measurements
Reliable Results
For increased overall accuracy of your dissolution
tests, this system utilizes easily calibrated and
traceable gauges to measure the actual centerline
offset for a shaft. It also measures the distance
between the bottom of the paddle or basket and the
inner apex of the bottom of the vessel.
Digital Measurements
The VK 5010 takes measurements digitally
eliminating visual interpretation and estimation and
removing the likelihood of human error.
VK 5010
Reproducible Results and Hard Copy Printouts

Consistently reproducible results are viewable on the
LCD display, and hard copy printouts are provided
by the on-board printer.
Non-volatile Memory
The VK 5010 is also capable of storing the following
data in non-volatile memory:
Tester serial number
Shaft ID
Vessel ID
Vessel position
The VK 5010 can store information for up to
30 testers at 8 vessels per tester.
Centerline Offset Measurement
Part Number
Description
12-0540
VK 5010 CLH Measurement System

centerline offset and height
measurement, 115 V or 230 V, includes
all necessary gauges
12-0531
Carrying Casehard plastic case with

cutouts for instrument and gauges
Paddle Configuration
Height Measurement
Basket Configuration
Height Measurement
39
CALIBRATION TOOLS
EaseAlign Shaft Wobble Gauge
Part Number
These gauges indicate shaft wobble in 0.001 inch or 0.01 millimeter

graduations and include a snap-in adapter for non-VanKel instruments.
Description
10-2429
Digital Wobble Gauge
12-7000
Analog Wobble Gauge, reads in 0.001 inch increments
12-7020
Analog Wobble Gauge, reads in 0.01 mm increments
12-7520
Calibration Certification for thickness and wobble gauge
Analogue Wobble Gauge
Tachometer, Hand-held
The hand-held tachometer measures RPM with continuous update each
second. The measured value can be stored and read on the display by
use of a slide switch. Unit includes three tips: cone shape, conical and
disk. The range is 1 to 19,999 with accuracy of 1.0, 0.5% of mean
value. The power supply is a 9V battery.
Part Number
Description
12-7100
Tachometer
12-7110
Calibration Certificate for hand-held tachometer
12-7120
Calibration Certificate with Calibration Data Sheet for

hand-held tachometer
Hand-held Tachometer
Height Spacers for USP Apparatus 1 and 2

The height spacers are easy to use and are designed for use with
VanKel testers. Height spacers A through E snap on the leg of the tester.
One spacer sets all paddle or basket heights at the same time.
Part Number
12-0321
Description
Spacer, 3.25 inch, for use with 100 / 200 mL vessels.
Can also be used with standard dissolution vessels
when more space between the head and the vessel
plate is desired. This application requires 19-inch
paddles. (A)
12-7210
Depth Spacer for basket (B)
12-7200
Depth Spacer for paddle (C)
12-0320
Height Gauge for use with 15 mm paddle and 100 /

200 mL round-bottom vessel (D)
12-7220
Depth Spacer for use with Peak Vessels (E)
12-7250
Spherical Height Gauge, 25 mm (F)
12-7260
Spherical Height Gauge, 38 mm for

intrinsic dissolution (not shown)
Part Number
NEW
Description
12-7270
Height Gauge for Paddlesattaches to paddles to

position 25 mm above bottom of vessel (G)
12-7280
Height Gauge for Basketsattaches to

basket to position 25 mm above bottom of vessel (H)
NEW
Height Spacers
40
Spacers and Centering Tools

Height tools can be used with dissolution testers
from any manufacturer.
E
d
an
F
B
Spacers and Centering Tools
Part Number
Description
12-7311
Centering tool for use with stainless

steel centering rings. Stainless steel
gauge for checking the centering of
3/8-inch diameter basket or paddle shaft
with dissolution vessels. (A)
12-7310
Centering Pass / Fail Gauge for use with

EaseAlign centering rings. Aluminum
gauge for checking the centering of
3/8-inch diameter basket or paddle shaft
with dissolution vessels. (B)
12-7300
Height tool, stainless steel, to accurately

set the depth (2.5 cm) of the paddle or
basket for USP Apparatus 1 and 2
dissolution tests. (C)
12-7301
Height tool, stainless steel, similar to item

C designed for 2-liter vessels (2.5 cm)
depth with longer handle for deeper
vessel. (D)
12-7330
Height tool, stainless steel, similar to

item C designed with (4.5 cm) depth as
required in some instances for dissolution
testing of antibiotics. (E)
12-7230
Height tool, special design, made of

stainless steel and delrin, to be used with
Peak vessels. (F)
12-7320
Circular level for all directional

horizontal leveling. Base of level is
3/4-inch diameter. (G)
Did
you
know?
When using Peak Vessels, the height is set

as if the indentation were not present.
PN 12-7230 takes this into account,
making it easy to set the height.
41
VanKel Verified Vessels
Individual certificate
Critical dimensions measured
Results are traceable
If an apparatus is not set up correctly from the start,

it is going to need attention in the future. The
VK Verified program is your assurance that your
accessories will conform to all regulatory standards,
as well as to the more stringent internal
specifications of VanKel.
Almost all dissolution vessels are hand-made from
glass tubing. Due to hand-forming, no 2 vessels are
exactly alike. This is particularly important for the
bottom curvature. As of this publication, there are no
published specifications as to the hemisphericity of
the vessel. At VanKel, weve created our own
tolerances based on those the USP has
recommended for the ID. The diameter (1) has a
USP tolerance of 4 mm. We have taken half of this
value and created a requirement for the hemisphere
(3) to be 2 mm. We inspect each vessel and record
the actual dimension. The resultyou get vessels
that are neither too shallow nor too deep and a
certificate to verify the actual dimensions.
The benefit to you is greater consistency of test

results. Although not exactly alike, these VK verified
vessels are held to very tight tolerances. Substituting
a VK verified vessel for a broken vessel should yield
no perceptive difference in results. A certificate is
included to provide the actual measured values, the
type of measuring device used, and its traceability.
Part Number
12-5005V
Description
Certified Glass Vessel, serialized
1000 mL for Apparatus 1 and 2
800.229.1108 (within the US) 919.677.1108 FAX 919.677.1138 Vankel.Info@vankel.com www.vankel.com
VESSELS
42
Glass Dissolution Vessels
Serialized
Wide range of sizes
Custom versions available (amber-coated or
Teflon-lined)
1000 mL Vessels
The standard 1000 mL vessels are designed to meet
or exceed current USP specifications. All are
individually serialized for documentation purposes
and easy relocation.
Part Number
Description
12-5000
USP Vessel, 1000 mL standard
12-5010
USP Vessel, 1000 mL amber-tinted
12-5020
Vessel, 1000 mL Teflon-lined (interior

lower hemispherical radius only)
Amber-tinted
1000 mL
100 mL, 200 mL, 500 mL, 2L and 4L Vessels

Part Number
Description
Glass Dissolution Vessel

12-5040
100 mL, round-bottom
12-5041
100 mL, amber-tinted, round-bottom
12-5050
12-5051
12-5055
200 mL, flat-bottom, self-aligning

indentation for use with Enhancer Cell
12-5060
12-5065
12-5070
USP 2L, round-bottom
12-5075
USP 2L, amber-tinted, round-bottom
12-5080
USP 4L, round-bottom
12-5090
USP 4L, amber-tinted, round-bottom
Teflon-lined
200 mL 200 mL 100 mL

PN 12-5055
500 mL
Peak Vessels
4L
2L
Patent 5,700,087
The Peak vessel reduces the inherent

inconsistencies in the hydrodynamics of standard
hemispherical dissolution vessels. An inverted peak
is designed into the bottom of the vessel, displacing
the unstirred zone, preventing cone formation.
Part Number
Description
12-5500
Peak Vessel 1L
12-5025
Peak Vessel 1L, Teflon-coated bottom
12-5510
Peak Vessel 2L
12-5520
Peak Vessel 4L
Peak
VanKel Peak Vessel

For more detailed information
regarding studies preformed
with the Peak Vessel, call the
VanKel Hotline for a reprint of
the article: Improved
hydrodynamics for USP
Apparatus 2.
TruCenter Vessels
Patent Pending
NEW
Empty vessels will not float

Retrofit kits available
All dissolution vessels have inconsistencies in the

glass thickness. Consequently it is difficult to center
from the outside of the vessel. Not any longer!
These dissolution vessels have a ground concentric
ring around the outside which holds a centering
collar in place. The result is a vessel for which you
can establish the true center from the outside.
Part Number
Description
12-5035
TruCenter Vessel, 1L, with ground

centering groove, vessel only
12-5037
TruCenter Vessel, 500 mL, with ground

centering groove, vessel only
12-6105
TruCenter Centering Collar
TruCenter Vessel must be used only with

VanKel testers equipped with the
TruCenter collar.
Plastic Dissolution Vessels

The standard 1000 mL plastic vessels are designed
to meet or exceed current USP specifications. The
plastic dissolution vessel has 3 molded feet for
support and is manufactured of polyethylene.
Part Number
12-5200
Description
Plastic Dissolution Vessel, 1000 mL
Plastic Vessel
Volumetric Flasks
This volumetric dissolution flask meets class A
specifications. A stopper is included and the flask is
designed with a space-saving square bottom. The
flasks are marked to deliver and to contain.
Part Number
Description
12-5300
Volumetric Flask, 900 mL
12-5310
Volumetric Flask, 500 mL
Calibrated Volumetric Flasks
NEW
This volumetric dissolution flask meets class A

specifications. Unlike other volumetric flasks, these are
calibrated to contain as well as deliver media at 37 C.
Most conventional flasks are calibrated at 20 C.
Part Number
43
Description
12-5315
Calibrated Volumetric Flask, 900 mL
12-5320
Calibrated Volumetric Flask, 500 mL
Volumetric Flasks
Did
you
know?
Preheating media in
volumetric flasks can save time. Be sure
to verify the volume when the media is at
37 C. The volume will differ from that at
room temperature.
44
VESSEL CENTERING RINGS

TruCenter System
NEW
Patent Pending
This system assures you of perfectly centered

vessels every time. We start by turning a dissolution
vessel and grinding a concentric ring around the
outside of the glass vessel. Next we fasten a
centering collar around the ground ring and place
the system into the alignment plate. The result is a
vessel that can be perfectly centered. One less
variable for you to worry about. Once your vessels
are in place, they will not float. This system can be
retrofit to any existing VK 7000 or VK 7010 bath.
Part Number
Description
12-6100
TruCenter System Conversion Kit

includes vessel, centering collar and
alignment plate
12-5035
TruCenter Vessel, 1L, with ground

centering groove
12-5037
TruCenter Vessel, 500 mL, with ground

centering groove
12-6115
TruCenter Alignment Plate
12-6105
12-6120
Pegs for Alignment Plate
12-6110
O-rings for TruCenter Centering Collar
12-6327
Evaporation Covers for TruCenter

Vessels
Stainless Steel Centering Rings

These centering rings provide easy, one-time
centering. PN 12-6000 includes the upper and lower
rings with locating pins to position vessels and
thumb screws to lock the vessel in place.
Part Number
Description
12-6000
Upper and Lower Ring Assembly,

stainless steel
12-6004
Centering Ring, 4L, stainless steel
12-6005
Replacement Gasket
12-6010
Replacement Knobs (2)
12-6015
Upper Centering Ring, stainless steel
12-6020
Lower Centering Ring, stainless steel
12-6025
Adapter Plate for 200 mL conversion kit
Stainless Steel Centering Rings

Patent 5,403,090
These centering rings position the vessels accurately

using the inside diameter of the vessel. Empty
vessels will not float. Locating pegs mounted on the
vessel plates ensure centering each time a vessel is
placed in position. Does not include evaporation
cover or pegs. For use with VK 700, VK 7000 and
VK 7010.
Part Number
12-6050
Description
EaseAlign Centering Rings only
EaseAlign Centering Retrofit Kits

Upgrade your VK 600, 6000, 6010 or Hanson
dissolution testers to accommodate VanKels
EaseAlign Centering Rings. Also designed for use
with most dissolution baths. Easy to assemble.
Part Number
Description
12-6060
EaseAlign Centering Ring 6-position Kit
12-6062
EaseAlign Centering Ring 8-position Kit
12-6065
EaseAlign Locating Pegs, set of 12
12-6070
Complete Conversion Kit for Hanson,

set of 6
EaseAlign Centering Retrofit Kit
VESSEL EVAPORATION COVERS

Evaporation covers slow the loss of media during
dissolution testing.
Part Number
Description
Evaporation Cover for Stainless Steel Rings

12-6200
Standard
12-6205
Robotic Zymark type
12-6210
Amber-tinted
12-6306
For use with baskets
12-6325
For use with 4L vessels
Part Number
Vessel Evaporation Covers for Stainless Steel

Centering Rings
Description
Evaporation Cover for EaseAlign Centering Rings

12-6300
Standard, PETG construction (A)
12-6301
Standard, PVC construction
12-6305
For rotating basket - auto start (B)
12-6310
For Dosage Delivery Module type (C)
12-6330
Solid for use in 7th or 8th position with

an EaseAlign ring when no vessel is in
use (D)
12-6315
200 mL
12-6320
Amber-tinted (same design as

PN 12-6300)
12-0463
Evaporation Cover, basket, Agilent

molded
12-0464
Evaporation Cover only for auto start

with baskets
45
D
Vessel Evaporation Covers for EaseAlign
Centering Rings
46
Low Loss Evaporation Cover

The unique conical design of these low loss
evaporation covers causes condensation to return to
the vessel and is ideal for extended testing. The low
loss evaporation cover dramatically reduces media
loss during long runs. Use with VanKels EaseAlign
Centering Rings.
Part Number
12-0469
Description
Low Loss Evaporation Cover, conical
shape for extended release analysis
Hinged Low Loss Evaporation Cover
Low Loss Evaporation Cover
NEW
VanKels new, two-piece, hinged evaporation cover

is designed for all systems where the evaporation
cover sits directly on the dissolution vessel (either 1L
or 500 mL). Its unique conical shape causes
condensation to return to the vessel. Split hinge
design makes manual sampling easy.
Part Number
12-6327
Description
Evaporation Plugs
Press-fit plugs are used to close sampling holes in
evaporation covers (PNs 12-6300, 12-6305 and
12-6310).
Part Number
12-6350
Description
Set of 36
Evaporation Plugs
47
PADDLES
All VanKel accessories are lot inspected. Many

customers request their accessories be individually
inspected, measured and documented. We now
offer this service for a number of accessories. A
certificate is included to provide the actual measured
values, the measuring device used, and its
traceability.
Part Number
Description
Teflon-coated Paddles
12-1000V
15-inch Shaft with individual inspection

certificate
12-1010V

certificate
12-1015V

certificate
Uncoated Electropolished Paddles

12-1030V

certificate
12-1040V

certificate
12-1045V

certificate
PEEK Paddles
12-1201V

certificate
12-1211V

certificate
VanKel Verified Paddles
48
USP Apparatus 2
Dissolution Paddles
NEW
Teflon-coated
PEEK
These paddles are serialized and designed to meet or

exceed current USP specifications for Apparatus 2.
They are constructed of type 316 stainless steel and
have a 3/8-inch diameter shaft. The blade and lower
part of the shaft are Teflon-coated.
These paddles are serialized and of single-entity

construction. The shaft is manufactured of type 316
stainless steel with a 1/16-inch thick PEEK sleeve
and solid PEEK blade. These paddles meet all the
dimensional specifications of the USP, EP and JP for
Apparatus 2. PEEK paddles are impervious to most
types of media used in dissolution. They offer
greater chemical resistance and have greater rigidity
(thereby ensuring the proper shape is maintained).
Part Number
Description
12-1000
15-inch Shaft, Teflon-coated
12-1010
12-1015

Part Number
Description
12-1201
15-inch Shaft, PEEK
12-1211
19-inch Shaft, PEEK
Electropolished / Stainless Steel

These paddles are serialized and designed to meet or
exceed current USP specifications for Apparatus 2.
They are electropolished and constructed of type 316
stainless steel. The shaft is 3/8-inch diameter.
Part Number
Tefl
o
n-co
Description
12-1030
15-inch Shaft, electropolished
12-1040
12-1045
Elec
trop
olis
hed
ated
/ Sta
inle
ss S
teel
PEE
Paddles
Dura-Tef Replacement Blade and Shafts

Part Number
Description
Teflon Replacement Blade

12-1220
Blade with 1/4-inch diameter opening
12-1225
Blade with 3/8-inch diameter opening
12-1226
Blade fits 1/4-inch threaded shafts,

meets USP dimensional specifications
Dura-Tef Replacement Blade and Shaft
Dura-Tef Shaft
12-1221
15-inch Shaft only, 3/8-inch
12-1222
12-1223
Did
you
know?
PEEK (polyetheretherketone) is biocompatible,

chemically inert, and can be used to replace
stainless steel in most liquid analytical
equipment systems.
49
The mini paddle is made of type 316 stainless steel. It

has a 1.174-inch (29.8 cm) paddle diameter and either a
1/4-inch or 3/8-inch diameter shaft.
Part Number
Description
Mini Paddle
12-1300
Teflon-coated, 1/4-inch diameter shaft
12-1305
Teflon-coated, 3/8-inch diameter shaft
12-1310
Electropolished, 1/4-inch diameter shaft
12-1315
Electropolished, 3/8-inch diameter shaft
Mini Paddle pictured in a 100 mL

dissolution vessel. Vessel not included.
To use the mini paddles, you need the 1/4-inch collet

(see below) with the VanKel type 316 stainless steel
chuck assembly.
Mega Paddle
This paddle can be used in 2L and 4L vessels when
greater fluid movement is required. The proposed
modification to USP dissolution Apparatus 2 may be
found in Pharmacopeial Forum volume 24, number 3,
page 6351.
Part Number
12-1318
Description
Mega Paddle 24-inch, 3/8-inch diameter
shaft
Mega Paddle
Paddle / Basket Support Rack

Protect your investmentavoid bends and nicks. The
support rack, with sturdy acrylic construction, holds 12
dissolution paddles or basket shafts.
Part Number
12-1350
Description
Paddle / Basket Support Rack
Support Rack
Replacement Collets for VanKel Testers

Interchangeable collets allow the use of 3/8-inch or
1/4-inch shafts. Collets are ideal for use with mini
paddles or baskets. Collets have 3-point shaft alignment
and support. They are for use with VanKel stainless steel
spindles. A nose piece and ring secure the collet on the
shaft.
Part Number
Description
12-1320
Collet for use with 3/8-inch diameter shaft
12-1330
Collet for use with 1/4-inch diameter shaft
Collets
Mini Paddles for 100 and 200 mL

Dissolution Vessels
50
BASKETS
VanKel Verified Baskets
VK Verified is your assurance the accessories you

are using meet all the required specifications. We
provide an individual certificate for each basket
detailing the USP specifications, the measured
value, the measuring device used, its serial number
and the date of its inspection.
Part Number
Description
Rotating Basket Assembly

12-2000V
USP 15-inch Shaft, standard head with

individual inspection certificate
12-2020V

12-2025V

Basket Drive Shafts

12-2070V
15-inch Shaft, USP standard head with

12-2080V

12-2095V

Baskets Only, Standard

12-2100V
USP Basket, 40-mesh, type 316 SS

basket standard with individual
inspection certificate
12-2120V
USP Basket, 20-mesh, 864-micron, type

316 stainless steel basket with
51
USP Apparatus 1
Shaft with 40-mesh Basket

The rotating basket assembly is individually
serialized with the serial number laser imprinted on
the shaft for record-keeping purposes. These
assemblies meet USP specifications requiring 3
retention spring clips for Apparatus 1. The shaft is
electropolished (except PN 12-2030 which is Tefloncoated) and constructed of type 316 stainless steel.
It is 15 inches long with a 3/8-inch diameter. Each
basket assembly comes with a Certificate of
Compliance.
Part Number
Description
USP Rotating Basket Assembly

12-2000
15-inch Shaft, standard
12-2020
12-2025
Part Number
Description
Shaft with Conical Head and Basket

12-2010
15-inch Shaft, conical head, disperses

bubbles
12-2030
15-inch Teflon-coated Shaft, (lower 6

inches Teflon-coated) and Teflon-coated
40-mesh Baskets
Did
you
know?
The current USP Apparatus 1 basket shaft

requires three retention clips on 120 degree
centers to hold the basket
in place.
Stationary Basket Assembly

The stationary basket assembly is a stationary
basket attached to the evaporation cover which is
held in place above a rotating paddle by a 1/4-inch
diameter shaft. The 4-inch long shaft constructed of
type 316 stainless steel is threaded at one end for
assembly to the flask cover. The assembly includes
1 mesh basket, 1 basket shaft and fasteners.
Part Number
Description
12-2060
Basket Shaft and 20-mesh Basket
12-2061
12-2063

Stationary Basket Assembly (paddle is
shown for illustrative purposes only)
52
Basket Drive Shafts
Dura-Fit Basket Shafts

The Dura-Fit basket shafts are individually serialized and
are shipped with a Certificate of Lot Compliance. The
3/8-inch diameter shafts are manufactured of type 316
stainless steel. The heads have O-rings for press fit
attachment of the baskets.
Part Number
Description
Dura-Fit Basket Shaft

12-2040
15-inch Shaft, standard head
12-2050
15-inch Shaft, conical head disperses air

bubbles
12-2093
15-inch Shaft, lower 6 inches Teflon-coated
12-2055
19-inch Shaft, standard head
12-2056

bubbles
Dura-Fit Conical Head
Dura-Fit Standard Head
Basket Drive Shafts

The electropolished basket shafts are individually
serialized and are shipped with a Certificate of Lot
Compliance. The drive shafts are only for use with USP
Apparatus 1. The 3/8-inch diameter shafts are
manufactured of type 316 stainless steel. There is a clip
assembly to attach baskets to the shafts.
Part Number
Description
Basket Drive Shaft

12-2070
15-inch Shaft, USP standard head
12-2080
12-2095
12-2075

bubbles
12-2081

bubbles
12-2085
15-inch Shaft, lower 6 inches gold-plated
12-2086
19-inch Shaft, lower 6 inches gold-plated
12-2090
12-2091
12-2097
15-inch Shaft for Bolus Basket (shaft only)
Conical Head Shaft
Gold-plated shaft
Teflon-coated Shaft
Shaft Lock Ring

This adjustable shaft lock ring with type 316 stainless
steel collar is used to preset the basket shaft height.
Part Number
12-2099
Description
Shaft Lock Ring, set of 6
Shaft Locking Ring
53
Standard Baskets
Part Number
Description
12-2100
USP Basket, 40-mesh, type 316

stainless steel, standard
12-2105
USP Basket, 40-mesh, gold-plated

Note: gold-plating may reduce micron
opening
12-2110
Basket, 40-mesh, Teflon-coated, type

316 stainless steel
Note: Teflon-coating may reduce micron
opening
12-2115
Basket, 40-mesh, type 316 stainless

steel, 3-fin assembly,
12-2120
Basket, 20-mesh, 864-micron, type 316

stainless steel
12-2125
Basket, 10-mesh, 1905-micron, type

316 stainless steel
12-2130
Suppository Basket, slotted, plastic
See the following page for additional custom

baskets.
Did
you
know?
Stainless Steel
Gold-plated
Teflon-coated
All stainless steel baskets are vulnerable to

wear over time. Openings increase as
wire diameters decrease. Replace your
baskets as necessary.
Suppository Basket
You wrote the book!

This compilation of the Dissolution Discussion Groups first year of business is
certain to be one of your most valuable reference books on dissolution. This hard
cover text, containing over 300 pages, includes:
Meeting notes from the Dissolution Discussion Group (DDG) regional and annual
meetings.
Transcripts of online discussions and comments submitted to the DDG Web site.
An appendix of USP and EP Apparatus.
A complete glossary of over 200 terms defined and cross-referenced.
See page 152 for more information on the DDG.
Order PN 70-1000 today!
3-fin
The standard baskets fit the standard USP rotating

and stationary basket shafts. USP standard
40-mesh baskets are serialized for traceability.
54
Mini Baskets
This new size basket fits on a specially designed

Dura-Fit basket shaft. Use with 100 and 200 mL
vessels. Inquire about other mesh and micron sizes.
Specifications
Inside diameter: 990.6 mm (0.39 inches)
Height: 32 mm (1.26 inches)
Part Number
Description
12-2057
Mini Basket, 40-mesh and Dura-Fit

Shaft, 15-inch
12-2102
Mini Basket, 40-mesh (basket only)
12-2077
Dura-Fit Shaft, 15-inch for 1/4-inch

drive (shaft only)
Mini Basket and

Dura-Fit Shaft
Custom Baskets
VanKel can manufacture custom-made baskets to
your specifications. We have manufactured the
following basket configurations which fit standard
USP shafts in the past. Contact your VanKel
representative if you are interested in one of these,
or one with different specifications.
Part Number
Description
12-2140
450 x 2750 mesh, 1-micron
12-2145
12-2146
12-2148
12-2149
12-2150
12-2151
12-2152
12-2154
12-2155
12-2160
Baskets - mesh vs. micron
Did
you
know?
Fabricated with 316 stainless steel, baskets

have a standard mesh screen of 40. Mesh is
defined as the number of openings per linear
inch. Another term often associated with mesh
size is micron, which is defined as the size of
the openings. The number of openings per
linear inch and the diameter of the wire will
affect micron size.
Bolus Baskets
The following bolus baskets require a special shaft,
PN 12-2097 (see page 52).
Specifications
Inside diameter: 30 mm (1.18 inches)
Height: 94.97 mm (3.74 inches)
Part Number
Description
12-2180
12-2185
40 x 40 mesh
Bolus Baskets
55
Wire
This wire is flexible enough for weighting capsules. It
is type 316 stainless steel wire and meets current
USP specifications.
Part Number
Description
12-3000
Stainless Steel Wire, 50-foot roll

Stainless Steel Wire
VanKel Type Capsule Weights

The three-prong assembly retains the capsule.
Capsule weights fit capsules sizes three through
one. The part numbers listed below are for capsule
weights sold individually.
Part Number
Description
12-3050
Capsule Weight, three prong
12-3055
Capsule Weight, three prong robotic

type with magnetic contact on end of
capsule weight
12-3056
Capsule Weight, robotic, with steel

embedded in each capsule leg. Assures
better contact during retrieval.
VanKel Type Capsule Weights
Sinker Baskets
The sinker baskets are designed to retain the
dosage form at the bottom of the vessel. They are
made of type 316 stainless steel and use press-on
caps (with O-rings). They are currently manufactured
in 6 mesh sizes. Custom mesh sizes are available
call for details.
Specifications
Inside diameter: 20.2 mm (0.8 inches)
Inside height: 11.7 mm (0.46 inches)
Part Number
Sinker Baskets
Description
Sinker Basket
12-3060
Enclosure 10-mesh, 1905-micron
12-3062
12-3064
Enclosure 40-mesh
12-3066
12-3068
12-3072
12-3070
Japanese Sinker Basket, JP 13 version
Japanese Sinker Baskets
CAPSULE WEIGHTS
56
MANUAL SAMPLING CANNULA ASSEMBLY

Cannula - Luer Lock Type
The cannula is bent for easier accessibility to USP
sampling position. Type 316 stainless steel with
stainless steel Luer fitting. Use with Full Flow filters
(see page 57).
Part Number
Description
12-3200
Bent Cannula, 4.75-inch, for sampling

900 mL
12-3210
Bent Cannula, 7.75-inch, for sampling

500 mL (A)
12-3211
Bent Cannula with Luer fitting for

sampling from 1L vesselincludes
height-adjustment gauge to ensure you
sample at the correct height each time
(C)
12-3215
Bent Cannula, 4.75-inch, with adjustable

gauge for setting proper height
12-3216
Bent Cannula, 7.75-inch, with adjustable

gauge for setting proper height
12-3220
Filter Holder, 25 mm
Glass Syringe
This 20 cc Luer-type syringe is graduated to 1 cc.
Part Number
Description
12-3230
Glass Syringe only, 20 cc (B)

Manual Sampling Manifold
Sampling Syringe Assembly

The sampling syringe assembly includes a 20 cc
syringe and a cannula.
Part Number
Description
12-3240
Syringe with 4.75-inch cannula
12-3250
Syringe with 7.75-inch cannula (A & B)
Manual Sampling
Did
you
know?
Manual Sampling
To gain more working room when sampling
manually, use spacer PN 12-0321 (see page 39).
When used with 19-inch paddles, this allows for
greater accessibility.
57
CANNULA FILTERS
Full Flow Filters

Dissolution continues until the sample is filtered. The
Full Flow filter, when attached to a manual or
automated sampling cannula, provides immediate
filtration which preserves the integrity of the
dissolution sample.
Filters are made of ultrahigh molecular weight
(UHMW) polyethylene. The increased surface area
of the Full Flow filter versus conventional filter tips
optimizes filter life. Use with 1/8-inch cannulas. Sold
in package and case quantity.
Full Flow filters are color coded to avoid using the
wrong porosity.
Part Number
Full Flow Filters
Description
Full Flow Filters

17-4000
Blue, 10-micron, package of 100

(available in cases of 1000)
17-4010
White, 35-micron, package of 100

17-4020
Red, 70-micron, package of 100

Full Flow Filter on Cannula
Did
you
know?
Proper Sampling Position

When sampling, withdraw a sample from
a zone midway between the surface of
the dissolution medium and the top of
the rotating basket or blade,
not less than one centimeter
from the vessel wall.
Full Flow Filter Filtration Diagram
58
Conventional Filter Tips

Filter tips are made of polyethylene and are for use
with 1/8-inch cannulas. Sold in package and case
quantity.
Part Number
Description
Filter Tips
17-4100
2-micron, package of 100 (available in

cases of 1000)
17-4110

cases of 1000)
17-4120

cases of 1000)
17-4130

cases of 1000)
17-4140

cases of 1000)
Conventional Filter Tips
Automation Filters
These 25 mm disk filters are individually lot analyzed
and designed to work with VanKels Automated Filter
Changer (see page 94) as well as the Zymark
Multidose and Tablet Processing Workstation (TPW).
The specially designed housing prevents the
membrane from being compressed. VanKel offers
nylon and PVDF filters as standard products. Filters
are packaged in boxes of 200 and prestacked in
tubes of 25 for easy loading. Other membrane types
are availablecall VanKel for details.
Part Number
17-4200
17-4210
17-4220
Description
Filter, 1.0 m APFB glass fiber prefilter
for processing and clarification of
aqueous and organic solutions
containing high particle levels
Filter, 0.45 m low protein binding
PVDF membrane for processing and
clarification of aqueous and mild organic
solutions
Filter, 0.45 m nylon membrane for
processing and clarification of aqueous
and organic solutions
Automation Filters
Did
you
know?
Deaeration is the process of removing dissolved

gases from a liquid media. The USP method of
deaeration is to heat the media to 41 C with gentle
stirring. Filter under vacuum using a filter having a
porosity of 0.45-micron or less with vigorous
stirring and continue stirring under vacuum for
approximately 5 minutes. Other validated
deaeration methods can be used.
59
RESIDENT CANNULA KITS
Part Number
Where the addition and removal of a sampling

cannula is not mechanically practical, the resident
cannula kit allows you to interface with Agilent,
Beckman, Perkin Elmer and many other UV
instruments for online analysis.
Description
12-0450
Resident Cannula Kit for Stainless Steel

Centering Rings (set of 6)
12-0455
Resident Cannula Kit for EaseAlign

Centering Rings for use with paddles
(set of 6)
12-0447
Cannula and Bushing only

(sampling 4.5 in)
12-0460

Centering Rings for use with baskets
(set of 6)
12-0465

Centering Rings (1 each)
12-0467
Cannula and Bushing (return 2.5)
12-0468
Evaporation Cover only with UV-VIS

adapter for use with EaseAlign
Centering Rings
Resident Cannula Kit
See page 45 for evaporation covers.
VanKel - Your Source for Practical Solutions

Practical Solutions is a quarterly publication.
Our goal is to provide you with a timely communication
vehicle for new regulations, helpful hints
and product updates.
Call today for a free subscription or to receive past
issues including topics such as:
Intrinsic Dissolution Testing: a valuable

characterization tool
Improving Workflow in Your Lab
Precalibration Routine for USP Suitability
Testing of Dissolution Apparatus 1 and 2
60
INTERNAL DOSAGE DELIVERY

MODULE RETROFIT
Saves time
Easy and precise way to drop tablets for
automatic (simultaneous or sequential)
delivery of dosage forms to vessels with
instant or delayed start through keypad or
computer control
Eliminates errors when manually dropping
tablets or capsules
For the VK 7000 Dissolution Tester
This option replaces the existing top cover of the

dissolution tester with a new one containing motors,
staging platforms and Dosage Delivery Module
tubes. This retrofit requires a service technician to
install.
Part Number
Description
12-0101
Dosage Delivery Module for 6-vessel

Benchsaver 3+3
12-0104

Easy Access 4+2
12-0106

Easy Access 4+4
12-0111

Easy Access 4+3
Replacement Delivery Tubes

The dosage form drops into the vessel through
internal delivery tubes. The replacement tubes are
sold in sets of eight and have a threaded end for
easy replacement (except PN 12-0115).
Part Number
Description
12-0115
DDM Tubes (external) with O-rings

(set of 8)
12-0120
DDM Tubes (internal) for use with

VK 7010 (set of 8)
12-0121
DDM Tubes (bottom extension) for use

with VK 7010 (set of 8)
DDM Tubes
Dissolution Discussion Group

www.dissolution.com
See page 152 for more information on the DDG.
000
2
r
Ove mbers
me dwide
l
wor
Join fellow analysts from around the world for an on-going open discussion on
dissolution issues. Free to join; free to use. You can register online at www.dissolution.com.
Mission Statement
Our mission is to provide an independent forum to freely discuss the practical issues which challenge the
industry and affect the day-to-day task of performing dissolution tests and chemical analysis.
61
TEMPERATURE CONTROLLER
AutoTemp In-vessel Temperature

Sensing System
Individual vessel temperatures measured and
recorded
Monitor media temperatures and
automatically start a test once all the vessels
have stabilized
The new AutoTemp System board plugs directly into

the RS232 serial port on your VK 7000 Dissolution
Testing Station. AutoTemp measures individual invessel temperatures, transmitting them via the
RS232 serial port and displaying them on the status
screen of your VK 7000. Sensors are lowered into
the vessels by a motorized manifold and then
removed as soon as temperatures have been
measured to eliminate disturbances associated with
resident dwelling probes during the test. The
AutoTemp accessory is available factory installed
when ordered with a new bath or can be retrofit to
an existing unit. You can program the frequency at
which you wish to monitor and record the
temperature.
Sampling and Temperature Cannula Assemblies
Internal Connection Includes Internally Mounted

Motor Drive
Part Number
Description
12-0601
AutoTemp for 6 vessels, 3+3
12-0606
12-0611
12-0616
Internal Connection without Motor Drive

(for units already equipped with Automated Sampling
Manifold)
Part Number
Description
12-0651
12-0656
12-0661
12-0666
The built-in dot matrix printer documents

the temperature for individual vessels
before and after the test and at
programmable intervals.
62
MOTORIZED SAMPLING MANIFOLD

When using the manual sampling bracket, you will
lower the sampling manifold with the touch of a
button on the front panel of the VK 7000 or VK 7010.
All of the sampling cannulas are lowered into the
vessels simultaneously. Included is the manifold,
internal drive motor, sampling bracket and all tubing
and connections. Includes manual sampling bracket
(PN 17-3150).
Part Number
Description

17-3350
3+3 configuration
17-3355
4+2 or 4+4 configuration
MANUAL SAMPLING BRACKET

This bracket attaches to the spindle drive unit of a
VK 7000 or VK 7010. Designed for manual sampling,
a syringe can be attached to the bracket which is
connected to the automated sampling manifold. The
sampling manifold is lowered into place with the
push of a button. Simply pull the plunger of each
syringe to sample. This system easily incorporates
an in-line 25 mm syringe filter. This system assures
that you sample in the same location each time.
Requires motorized sampling manifold.
Part Number
17-3150
Description
Luer Fitting Bracket for manual
sampling (requires sampling manifold)
Manual Sampling Manifold
REPORT CENTER II RETROFIT KIT

This kit allows easy upgrading of older VK 700 and
VK 7000 equipped with thermal printers to Report
Center II dot matrix printer. Reports print on plain
paper which will not fade or discolor over time or
upon exposure to light. The retrofit kit contains
everything required, including a box of 10 plain
paper rolls.
Part Number
Description
12-0240
Report Center II for Easy Access

models 4+2, 4+4
12-0245
Report Center II for Benchsaver 3+3
12-9997
Replacement Ribbons, package of 5

ribbons
12-9995
Plain Paper, 2.25-inch wide, package of

10 rolls
12-9996
Plain Paper, 2.25-inch wide, case of 100
Report Center II Printer
63
Vessel conversion kits allow you to use your existing

equipment for testing with varying volumes of media.
Saves Money, Less Waste
Use the 100 or 200 mL conversion kits for tests
where a smaller volume is required. Save money
when preparing standards during automated analysis
by only preparing the amount you need. The
conversion kits work with EaseAlign Centering
Rings.
Did
you
know?
VanKels vessel conversion kits not only

work with VanKel dissolution testers, but
also with most other manufacturers
dissolution testers. See page 45
for PN 12-6070.
100 mL Conversion Kits

Part Number
Description
12-0310
100 mL Conversion Kit, single-vessel for

use with EaseAlign Centering Rings
(mini paddle not included)
12-0311
100 mL Conversion Kit, single-vessel for

use with EaseAlign Centering Rings,
includes mini paddle and collet
12-0320
15 mm Height Gauge for 100 / 200 mL

round-bottom vessel
12-1305
Paddle, Teflon-coated, 100 and 200 mL

(1/4-inch diameter shaft for 3/8-inch
drive)
12-1315
Paddle, electropolished, 100 and

200 mL (1/4-inch diameter shaft for
3/8-inch drive)
100 mL Conversion Kit
200 mL Conversion Kits

Part Number
Description
12-0300
200 mL Conversion Kit for use with

stainless steel centering rings, set of 6
12-0305

EaseAlign Centering Rings, set of 6
12-0306

12-0307

stainless steel centering rings, set of 8
12-0309

EaseAlign Centering Rings, set of 8
12-6025
200 mL Adapter Plate only for use with

stainless steel centering rings
12-1305
Paddle, Teflon-coated, 100 and 200 mL

(1/4-inch diameter shaft for 3/8-inch
drive)
12-1315
Paddle, electropolished, 100 and

200 mL (1/4-inch diameter shaft for
3/8-inch drive)
200 mL Conversion Kit
VESSEL CONVERSION KITS
64
USP LARGE VOLUME CONVERSION KITS
Offers great flexibility in changing from one

vessel size to another
The 2L and 4L conversion kits make your existing

dissolution tester more flexible by providing leg
extenders and an extra-deep water bath for use with
either standard 1L vessels or the larger vessels
provided with the kit you select.
The 2L conversion kit is available for the Benchsaver
or Easy Access models of the VK 700, VK 7000 or
the VK 6000 series dissolution tester. VK 7010 2L
conversion kits are available for the Easy Access
models only.
The 4L conversion kit is available only on the

Benchsaver model of the VK 7000 series or VK 6000
series dissolution testers. The convertible base plate
system allows easy switching between 4L vessels
with one plate and either 2L, 1L or 500 mL vessels
with the standard base plate. This kit requires a
VanKel field service technician or factory installation.
The 19- and 24-inch paddles and basket shafts are
sold separately (see pages 48-52).
2L Conversion Kits
Part Number
Description
2L Conversion Kits
12-0400
VK 700 / 7000 Benchsaver, 3+3 units
12-0415
VK 600 / 6000 / 6010 Benchsaver, 3+3 units
12-0420
VK 700 / 7000 / 7010 Easy Access, 4+2 and

4+4 units
12-0425
VK 600 / 6000 / 6010 Easy Access, 4+2 and

4+4 units
2L Conversion Kit
4L Conversion Kits
Part Number
Description
4L Conversion Kit
12-0440
VK 600 / 6000 / 6010
12-0445
VK 700 / 7000
4L Conversion Kit
65
INTRINSIC DISSOLUTION APPARATUS
Part Number
The VanKel Type Intrinsic Dissolution Apparatus is an

updated version of the original Wood Apparatus for
intrinsic dissolution. The VanKel design includes a
hardened punch, a controlled surface area and an
improved die design for more reproducible results. It is
designed to meet or exceed current USP specifications
as described in USP Physical Test <1087>. The ground
and hardened surface plate (ordered separately)
provides an ideal surface for compressing samples. The
intrinsic dissolution apparatus is designed for use with
standard USP Apparatus 1 and 2 dissolution testers.
Description
12-4100
Standard USP design consists of 0.5 cm

Holder, Punch and Die Cavity
(one setsurface plate not included)
12-4110
0.125 cm Holder, Punch and Die Cavity

(one setsurface plate not included)
12-4120
Intrinsic Die only
12-4130
Surface Plate (only one is required)
12-4140
Punch only
12-4150
Shaft and Holder only

Intrinsic Dissolution Apparatus
USP APPARATUS 6 ROTATING CYLINDER

USP Apparatus 6 is used for testing transdermal patches.
The rotating cylinder is manufactured of type 316 stainless
steel with removable extension. The rotating cylinder is
designed for use with standard USP Apparatus 1 and 2
dissolution testers.
Part Number
Description
Rotating Cylinder, 2-piece assembly

12-1360
USP 4.45 cm outside diameter
12-1365
2.5 cm outside diameter
Rotating Cylinder
Did
you
know?
Intrinsic dissolution is the dissolution of a pure

substance under conditions of constant
surface area expressed in terms of mg/time/cm.
Intrinsic dissolution is useful in studying the
solubility characteristics of a pure
drug substance.
66
SUSPENSION CUP
The suspension cup is a Teflon 2-piece assembly. The
weighted holder has a hemispheric bottom designed to
sit in the bottom of a 1L dissolution vessel. The
removable center cup, available in 2 sizes, allows
contents to be weighed, retains the suspension and
provides a controlled surface area.
Part Number
Description
12-4050
Weighted Holder only 5.72 cm outside

diameter, 2.52 cm inside diameter for
suspensions
12-4055
Insert Cup only 17.5 x 8.2 mm, use with

PN 12-4050 (exposed surface area
2.405 cm, vol 1.972 cm)
12-4060
Suspension Cup
Insert Cup only 20 x 8.2 mm, use with

PN 12-4050 (exposed surface area 3.14 cm,
vol 2.576 cm)
PADDLE OVER DISK ASSEMBLY

The paddle over disk assembly includes only the disk
assembly. The VanKel Type comes with a removable
disposable screen and a Teflon locking ring. The type
316 stainless steel ring keeps the screen in place.
Part Number
Description
Paddle Over Disk

12-4200
Assembly 35 mm opening (40-mesh screen),

meets USP Apparatus 5 specifications
12-4210
Replacement Screens for PN 12-4200,

type 316 SS (40-mesh screens), pack of 100
12-4211
Disassembly Tool for PN 12-4200
12-4230
Assembly 56 mm opening (120-mesh screen)
12-4231
Replacement Screens for PN 12-4230,

pack of 100
12-4232
Disassembly Tool for PN 12-4230
Paddle Over Disk Assembly
TRANSDERMAL PATCH HOLDER SYSTEM

Patent 5,108,710
This type 316 stainless steel 2-piece assembly provides

an easy-to-use alternative to the USP Apparatus 5. The
O-ring assembly eliminates the need for adhesives. It is
designed for patches with an inactive perimeter around
the release area. Custom holders (square, oblong) are
also availablecall us!
Part Number
Description
Transdermal Patch Holder

12-4300
Release area
12-4310
Release area
12-4320
Release area
12-4330
Release area
2.5 cm
5.0 cm
7.0 cm
10.0 cm
Transdermal Patch Holder System
67
PRODUCTS FOR RELEASE RATE STUDIES

Patent 5,408,865
Meets SUPAC SS guidelines

Ideal for use with topicals, such as ointments,
creams and suspensions
Can be used with traditional dissolution
apparatus
Available in surface areas of 4.0, 2.0 and
0.5 cm
Alternative to the Franz Cell
Teflon cell with adjustable volume and screw cap to

eliminate air pockets trapped against the skin or
artificial membrane. The result is more consistent
release rates. Designed for research, quality control
and product development laboratories, the Paddle
over Enhancer Cell method provides release rates
comparable to Franz Cell technology. It provides
release rate data for quality control of topicals using
readily available dissolution apparatus, including
200 mL or standard 900 mL dissolution vessels,
without the investment in fragile Franz Cells, pumps
and stirrers.
An alignment tool is used to hold the membrane in
place while using the adjustment tool to set the
volume adjustment plate. Only one alignment and
adjustment tool are required per size. When
purchasing more than one Enhancer Cell, order
separately.
G
E
D
0.5 cm
B
2 cm
4 cm
Adjustment Tool, Enhancer Cells (assembled)

and corresponding Alignment Tools
Part Number
Description
12-4000
Enhancer Cell, 4 cm only (A)
12-4010
Alignment Tool, 4 cm only (B)
12-4001
Enhancer Cell, 2 cm only (C)
12-4011
Alignment Tool, 2 cm only (D)
12-4002
Enhancer Cell, 0.5 cm only (E)
12-4012
Alignment Tool, 0.5 cm only (F)
12-4015
Adjustment Tool only, for all sizes (G)
12-5055
200 mL, flat-bottom, self-aligning

indentation for use with Enhancer Cell
The Enhancer Cell does not include the vessel,

paddle or membrane / skin.
Adjustment Tool
Alignment Tool
Adjustment Plate
with O-ring
Cell Body
Membrane or Skin
Washer
Retaining Ring
Adjustment Tool, Enhancer Cell (disassembled)
and Alignment Tool
Vessel, Mini Paddle

and Enhancer Cell
Enhancer Cell
68
Beyond
high
performance
products...
LABCAST
VanKels chemists
and technicians
are accessible via
live video feeds,
eliminating travel
costs.
SERVICE
Our service technicians

and chemists come to
your facility to perform
physical and chemical
calibration as well as
product maintenance,
maximizing your labs
productivity.
EDUCATION
Our team of expert

instructors will educate
and train your chemists
on all the various aspects
of dissolution testing,
ensuring efficient
application of current
methodologies.
YOUR
SOURCE FOR
PRACTICAL
SOLUTIONS
LAB SERVICES
From documentation to
compliance to education,
we are your Lab Partner,
providing assistance every
step of the way.
HOTLINE
Contact VanKel free

of charge for help with
any dissolution matter.
Call 888.VANKEL1
(888.826.5351) or e-mail
vankel_hotline@vankel.com.
At VanKel, we want to make sure you are minimizing the total cost of ownership of your dissolution equipment.
We go beyond supplying you with high performance products by providing the top-quality service and support you deserve.
Utilize our value-added services. Minimize cost. Maximize ownership.
Stop by and visit our dissolution demonstration lab in Cary, NC, or call your VanKel representative.

Dissolution: Dissolution Apparatus Overview 6 Dissolution Instrumentation 7

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Dissolution: Dissolution Apparatus Overview 6 Dissolution Instrumentation 7

Uploaded by

Copyright:

Available Formats

Dissolution

Dissolution Apparatus Overview

VanKel Total Solution

Dissolution Compatible Systems

Dissolution Vessel Washing Stations

Dissolution Apparatus Overview

Dissolution Apparatus Overview

Standard 40-mesh basket.

Standard stainless steel paddle or Teflon-coated

Sequential operation for pH profiling.

Standard stainless steel with disposable stainless screens.

Two-piece assembly for testing transdermal patches using

Utilizes sequential operation and a variety of dosage

VanKel Quality Policy

conduct design, product quality and program

implement procedures to ensure quality in

operate an effective quality reporting and

provide training programs relating to quality.

maintain the Quality System Manual, so as to

ensure the Quality Policy is understood,

Reliable and robust

The VK 7000 and VK 7010 models are designed

VK 7000 Options Display

Spindle Motor Monitor

Individual Spindle Control

Complete Operating System, No Post-purchase

Preconfigured for automated analysis

VK 7010 Automated Sampling Manifold

Dosage Delivery Module

Resident Probe Effect

Each of the following configurations includes your

6-spindle VK 7010 Benchsaver Vessel Plate

VK 7010, 3+3, 115 V, 60 Hz

VK 7010, 3+3, 230 V, 50 Hz

VK 7010 Easy Access

6-spindle VK 7010 Easy Access Vessel Plate

VK 7010, 4+2, 115 V, 60 Hz

VK 7010, 4+2, 230 V, 50 Hz

VK 7010 Easy Access

8-spindle VK 7010 Easy Access Vessel Plate

VK 7010, 4+4, 115 V, 60 Hz

VK 7010, 4+4, 230 V, 50 Hz

VK 7010 equipped with a 2L bath

Easy Access 4+2, 115 V, 60 Hz

Easy Access 4+4, 115 V, 60 Hz

Easy Access 4+4, 230 V, 50 Hz

Easy Access 4+2, 230 V, 50 Hz

VanKel is always working to develop new technology.

Microprocessor-controlled dissolution testing

These microprocessor-controlled units offer

VanKel offers a manual

Motorized Sampling ManifoldThere are two

Manual Sampling Bracket

Motorized Sampling Manifold

Each of the following configurations includes your choice

VK 7000, 3+3, 115 V, 60 Hz

VK 7000, 3+3, 230 V, 50 Hz

VK 7000 Easy Access

VK 7000, 4+2, 115 V, 60 Hz

VK 7000, 4+2, 230 V, 50 Hz

VK 7000 Easy Access

VK 7000, 4+4, 115 V, 60 Hz

VK 7000, 4+4, 230 V, 50 Hz