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VOL 2
ISSUE 4 (2014)
REVIEW ARTICLE
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Ambika Dhiman et. al., A Review Article on Anticancerous Drugs in Ayurveda and Screened Anticancer Activity of Medicinal Plants, Int. J.
Ayu. Alt. Med., 2014; 2(4):54-60
VOL 2
ISSUE 4 (2014)
eISSN
2348-0173
REVIEW ARTICLE
QR Code IJAAM
ABSTRACT:
Cancer also known as a malignant tumor, is a group of diseases involving
abnormal cell growth with the potential to invade or spread to other parts of the
body. Cancer prevalence in India is estimated to be around 2.5 million, with over
eight lakh new cases and 5, 50,000deaths occurring each year. According to
Ayurveda, in Cancer is termed as Arbuda which is resultant of vitiation of all the
three doshas. They intern vitiate 'mamsa and 'Rakta' results in Arbuda, Current
treatment modalities for cancer include radiotherapy used in conjunction with
chemotherapy or surgery as need be in order to minimize local control. As these
treatments are effective against cancer, they also have adverse effects on the
patient's body. Many plants have been documented in the Ayurvedic Classics for
their use in the treatment of Arbuda.3Also in the recent past many plants have
been screened for their anticancer activity. Some have them have also shown
promising results in vitro. At least these plants can be quite effectively used as
an alternative therapy to counteract the adverse effects produced by current
therapy. This
paper deals with the review of the medicinal plants told in
Ayurveda for Cancer and highlights the
related researches on plants with
promising results with their mechanism of action
Sr
No
Type
Vataja[3]
Pittaja[4]
Kaphaja[5]
Raktaja[6]
Ambika Dhiman et. al., A Review Article on Anticancerous Drugs in Ayurveda and Screened Anticancer Activity of Medicinal Plants, Int. J.
Ayu. Alt. Med., 2014; 2(4):54-60
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Page
INTRODUCTION
The word cancer has been introduced in modern
science only a decade ago. Naturally one cannot
except to find the exact synonym of the word
cancer in Ayurveda texts, but the word Arbuda in
Ayurvedic texts fulfills the most of the signs and
symptoms which are explained for the tumor1 .so
the word tumor can be correlated to the word
arbuda in Ayurveda. Like the different types of
cancer told in modern medicine, In Ayurveda
literature also we find the different type of cancer,
depending upon their site and origin eg. Valya,
Blasa , shataghni are the names of the cancers of
the throat.
Mamsja[7]
Medaja[8]
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Ambika Dhiman et. al., A Review Article on Anticancerous Drugs in Ayurveda and Screened Anticancer Activity of Medicinal Plants, Int. J.
Ayu. Alt. Med., 2014; 2(4):54-60
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Following are the formulations which are quoted in Ayurveda for the treatment of Arbuda [9]
Vataja arbuda
Paste of Benincasa cerifera, Cucumis memordica, Cocos nucifera, and Eranda beeja,
Ricinus communis along with butter or milk were applied
Pittaja arbuda
Tumors were treated with leaves of Ficus glomerata, Tectona grandis, and
Elephantopus scaber repeatedly and then with a honey mixed fine paste of Aglaja
roxburghiana,Caesalpinia sappan, Symplocos racemosa, Terminalia arjuna, Xanthium
strumarium was applied
Kaphaja arbuda
Jasminum grandiflorum and Nerium odorum leaves was used. For the postoperative
care, oil cooked with Premna herbacea, Embelia ribes, Cissampelos pareira was applied
Name of the
herb
Vitis vinifera
(Draksha)
Prosopis
cineraria
8 (Khejri)
Basella rubra
11 (Kalambi)
Flacourtia
12 romantchi
Moringa
oleifera
(Shigru)
13
The
paste
of Moringa
oleifera seeds, Solanum
xanthocarpum, Sinapis
dichotoma,Holarrhena
antidysenterica and Nerium
odorum roots prepared with buttermilk
is used for arbuda tumours
Ficus
14 bengalensis
(Vata)
Application
of
mixture
of Ficus
bengalensis and Saussurea lappa pacify
tumour growth on bone
Pandanus
A paste of Pandanus odoratissimum with
odoratissimum sugar was applied externally
Pterospermum The
flowers
of Pterospermum
5 acerifolium
acerifolium mixed with sugar to be
(Muchkunda) applied locally
Raphanus
sativus
6
(Mulak)
Local
application
of Raphanus
sativus powder paste with the radish ash
was considered effective against kaphaja
arbuda
Ambika Dhiman et. al., A Review Article on Anticancerous Drugs in Ayurveda and Screened Anticancer Activity of Medicinal Plants, Int. J.
Ayu. Alt. Med., 2014; 2(4):54-60
57
S.
No
Barleria
prionitis
7
(Kuranta)
Page
The Curcuma
domestica powder
in
combination
with Symplocos
racemosa, Soymida febrifuga, is mixed
with honey and this is used as an
external remedy
7) Semicarpus anacardium
In Ayurveda numerous references are available on
anticancer properties of Semecarpus anacardium
nuts .An extensive review describes the
phytochemical and pharmacological properties of
semecarpus anacardium. The chloroform extract of
Semecarpus anacardium nuts possesses antitumor
action which increases the life span against
leukemia, melanoma, and glioma. The milk extract
of Semecarpus anacardium produces regression of
hepatocarcinoma by stimulating host immune
system and normalizing tumors markers including
alpha fetoprotein levels. This preparation
stabilizes the lysosomes and normalizes
glycoprotein and mineral content in the body
during cancer progression, it also corrects
hypoglycemia and controls abnormal
lipid
peroxidation by the maintenance of antioxidant
defense status . In the microsomes, it acts as a
functional inducer of both phase I and II
biotransformation enzyme and prevents tumors
initiation by preventing carcinogen activation.[17]
7) Tinospora cordifolia
The active principles from Tinospora cordifolia
enhance host immune system by increasing
immunoglobulin and blood leukocyte levels and by
the stimulation of stem cells proliferation . It has
the ability to reduce solid tumour volume by
58.8% which is comparable to cyclophosphamide
,a known chemotherapeutic agent . these immune
stimulating properties can be used in the
prevention of tumors mediated immune
suppression and hence could be a drug choice for
various cancers.[18]
Table 3 Scientific evidence for the herbs having the
Anticancer Activity
Name of the
herb
Indications
Abrus
precatorius
Albizzia
lebbeck
Allium
sativum
Aloe vera
Alstonia
scholaries
Amura
rohitaka
Leukemia[23]
[19]
Fibro sarcoma
Ambika Dhiman et. al., A Review Article on Anticancerous Drugs in Ayurveda and Screened Anticancer Activity of Medicinal Plants, Int. J.
Ayu. Alt. Med., 2014; 2(4):54-60
58
Curcuma
domestica
15 (Haldi)
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Berberis
aristata
Boswellia
serrata
Calotropis
gigantean
Human epidermal
nasopharynx[24]
Curcuma
longa
carcinoma
carcinoma
Erythrina
suberosa
Sarcoma 180[20]
Euphorbia
hirta
of
of
the
the
Ixora
undulate
Juniperus
indica
Human epidermoid
nasopharynx[28]
Luffa
cylindrical
Schwartz leukemia[24]
Melia
azedarach
Moringa
oleifera
Nerium
indicum
sNigella
sativa
Ocimum
sanctum
Paederia
foetida
Human epidermoid
nasopharynx[20]
Picrorrhiza
kurroa
Hepatic cancers[20]
Plumbago
zeylanica
Hepatoma[31]
Rubia
cordifolia
Taxus
buccata
Vinca rosea
Withania
somnifera
Various tumors[20]
carcinoma
carcinoma
of
of
the
the
DISCUSSION
Review article means compilation of all text
references regarding one topic and previous
researches done like Tinospora cordifolia; by doing
various experiments we can conclude that it acts as
a immunomodulation drug, because cancer leads
to immunosuppressant. And other researches like
the milk extract of
Semecarpus anacardium
produces
regression of hepatocarcinoma by
stimulating host immune system and normalizing
tumor markers including alpha fetoprotein
levels. This preparation stabilizes the lysosomes
and normalizes glycoprotein and mineral content
in the body during cancer progression , it also
corrects hypoglycemia and controls abnormal
lipid peroxidation by the maintenance of
antioxidant defense status because it is having
tendency to act like this .so in proceeding to these
statements we can do animal experimentation and
after animal experimentation we can apply it in
clinical studies. further this paper will help in
Animal and clinical studies.
CONCLUSION
As the paper is concerned with the review of the
plants used in the treatment of cancer told in
Ayurveda and the plants among them and except
them which are screened for their anticancer
activity , hence there is a huge list of drugs which
is screened for the anticancer activity and among
the list very few drugs are being in clinical practice
and the others dont come in the practice because
of their toxicological effect. So when the drug is
going to be screened for the anticancer activity ,
Care should be taken for the safety usage of the
drug from its toxicity and then after the pre
clinical study clinical studies should be undertaken
to asses the efficacy of the drug.With the help of
this paper the drugs which are quoted to be having
anticancer property in Ayurveda can be screened
on the modern parameters for its scientific
validation.
The herbal drugs which are screened for the
activity and clinical trial are over can be used in
the clinical practices for treating the cancers as
quoted in the treatment modality in Ayurveda .
REFERENCES
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Ambika Dhiman et. al., A Review Article on Anticancerous Drugs in Ayurveda and Screened Anticancer Activity of Medicinal Plants, Int. J.
Ayu. Alt. Med., 2014; 2(4):54-60
59
Bacopa
monniera
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Ambika Dhiman et. al., A Review Article on Anticancerous Drugs in Ayurveda and Screened Anticancer Activity of Medicinal Plants, Int. J.
Ayu. Alt. Med., 2014; 2(4):54-60