Opening sentence of point paragraph advantages

Convenience aside, ____.

To a certain extent, ____.
More importantly, ____.
On top of that, ____.
____ are of the essence in ____.

Disadvantages
____ can cause detrimental effect in ____.
____ would be disastrous to ____.
____ has resulted in severe problems for the individual who ____.
____ can lead to frightening consequences.
____ can lead to dangerous encounters.
____ and the nightmare is unfathomable.
The question therefore would be, ____?

The most horrifying fact is that ____.

The main problem that requires immediate attention is ____.
The scenario becomes worse when ____.
The drawback I see is that ____.
____ has caused huge handicap in ____.