The Relationship Between

Metabolic Syndrome
&
Carotenoids
AMANDA ROSENBERG

tp://www.osablog.com/2013/04/sleep-and-metabolic-syndrome

http://www.super-lutein.net/export/sites/superlutein/en/gl/images/faq/image-01.jpg

Metabolic
Syndrome

Carotenoids

Metabolic Syndrome: Pro-oxidative

http://www.obesityresearchclinicalpractice.com/article/S1871403X%2813%2900043-4/fulltext

Carotenoids: Anti-oxidant
1.

Neutralizing singlet oxygen and are an effective scavenger of other reactive oxygen species

2.

Inhibit lipid peroxidation and scavenge lipid peroxyl radicals

3.

Act synergistically as an effective radical-trapping antioxidant which protects cells against

reactive nitrogen species

Metabolic syndrome and serum carotenoids:

findings of a cross-sectional study in Queensland,
Australia

-carotene, -carotene, -cryptoxanthin, lutein, lycopene, and total serum

carotenoids

Results:

All markers of carotenoid status had an inverse relationship with metabolic syndrome

Serum carotenoid status significantly as the number of metabolic syndrome markers and
as BMI

Participants who consumed 4+ servings of vegetables were less likely to have metabolic
syndrome than those who consumed 1 serving of vegetables a day

Conclusion: Those with metabolic syndrome may have oxidative stress and
vegetable intake

High serum carotenoid concentrations associated with a

lower prevalence of the metabolic syndrome in middleaged and elderly Chinese adults

-tocopherol, retinol, -carotene, -carotene, -cryptoxanthin,

lycopene, and lutein+zeaxanthin

Results:

Participants with metabolic syndrome had serum total carotenoids than those
without metabolic syndrome

The serum levels of each individual carotenoid significantly as the number of

metabolic syndrome components

Conclusions:

There was an association between serum carotenoid levels and a prevalence of

metabolic syndrome in Chinese adults

Serum Antioxidant Status Is Associated with

Metabolic Syndrome among U.S. Adults in Recent
National Surveys

-carotene, -carotene, -cryptoxanthin, lutein+zeaxanthin, lycopene, and total

carotenoids

Results:

Adults that met the criteria for metabolic syndrome had a serum carotenoid status

Total serum carotenoids, -carotene, -cryptoxanthin, and lutein+zeaxanthin were

significantly and inversely related to metabolic syndrome

Conclusion:

The underlying mechanism and complications of metabolic syndrome may be the oxidative
stress that accompanies obesity-related disorders

Serum Antioxidant Concentrations and Metabolic

Syndrome Are Associated among U.S. Adolescents in
Recent National Surveys

Serum retinol + retinyl ester, total carotenoid concentrations, -carotene,

-cryptoxanthin, and lutein + zeaxanthin

Results:

Participants that were diagnosed with metabolic syndrome had serum total
carotenoid concentrations, -carotene, -cryptoxanthin, and lutein + zeaxanthin

Conclusion:

Individuals with metabolic syndrome have higher levels of oxidative stress and may
have a higher dietary requirement for antioxidants.

Dietary Carotenoid Intake Is Associated with Lower

Prevalence of Metabolic Syndrome in Middle-Aged and
Elderly Men

Total carotenoids, -carotene, -carotene, -cryptoxanthin, lycopene, and lutein + zeaxanthin

Results:

There was an inverse relationship between higher total dietary carotenoid intake and diagnosis of
metabolic syndrome

intakes of lycopene, -carotene, and -carotene were associated with a risk for metabolic syndrome

total carotenoid, -carotene, -carotene, and lycopene were associated with waist circumference
and visceral and subcutaneous fat mass

-carotene and lycopene intakes were associated with BMI

lutein and zeaxanthin intakes were associated with lower subcutaneous fat mass

lycopene intake with serum triglyceride concentrations

Conclusion:

A intake of total carotenoids may the risk for metabolic syndrome

Effects of long-term antioxidant supplementation and

association of serum antioxidant concentrations with
risk of metabolic syndrome in adults

SUpplementation en Vitamines et Minraux AntioXydants (SU.VI.MAX) prevention trial:

Vitamin C, vitamin E, -carotene, zinc, and selenium

Results:

No difference in diagnosis of metabolic syndrome in the placebo or supplement group

Serum -carotene was inversely related with metabolic syndrome

Conclusion:

There was no benefit or adverse effect of multiple antioxidant supplementation on metabolic syndrome
incidence

Future Research

Randomized controlled trials are needed to assess whether

supplemental or dietary carotenoids may decrease the oxidative
damage associated with metabolic syndrome

http://www.healthierlifevitamins.com/uploaded/images/DATA%20FILES/FOOD%20SUPPLEMENTS/3300_carotenoidcomp_md.jpg

Clinical Pearls

The effect of long term carotenoid supplementation is still unknown

Encourage patients with metabolic syndrome or markers of metabolic syndrome to eat a high
carotenoid, high fruit and vegetable diet

Total carotenoid status may be part of a total panel of markers of oxidative damage

http://www2.mastoloni.com/assets/images/2010/06/8085-18-aafww-3.jpg

References
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