Penulis : Sularsih , drg

Fakultas : Kedokteran Gigi

Program Studi : Biomaterial
IPK : 3.90
Pembimbing I : Prof. Dr.Anita Yuliati,drg.,M.Kes
Pembimbing II : Prof. R.M. Coen Pramono D., drg.,SU.,SpBM(K)

Penggunaan Kitosan Dalam Penyembuhan Luka Pencabutan Gigi

Rattus Norvegius.
Abstrak :
Background. Chitosan have some characters such as good biocompability, non toxic. biodegradable,
hemostatic and healing accelerator. Chitosan have ability to facilitate migration, proliferation and
progenitor cell differentiation on wound healing process of dental extraction. Purpose. The aim of this
study was to account the rate of fibroblast cells, osteoblast cells and collagen type 1 on acceleration wound
healing process of dental extraction in Rattus norvegicus for 7 and 14 days. Methods. Rattus nornegicus
strain wistar male, aged 8-16 weeks, divided into 2 treatment groups namely group 1 which given chitosan
and group II as control which were not given chitosan. Chitosan were applied into the socket of dental
extraction. Rat was decaputated 7 and 14 days after chitosan application and the jaw in the treated regions
and control group were cut for histopatological to observe the number of fibroblast cells and osteoblast
cells. Immunohistochemical examination was used to observe collagen type 1. Data were analyzed using t
test. Results. The result showed significant differences in fibroblast cells, osteoblast cells and collagen
type 1, in 7 and 14 days observation (p
Keyword :
chitosan, fibroblast cell, chitosan, fibroblast cells, osteoblast cells , collagen type 1, wound healing process

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