Aim: To prepare and evaluate dry powder for oral suspension

Formula for Amoxycillin Trihydrate

Material
Amoxycillin Trihydrate
CMC
Aerosil
Color Tartrazine
Sodium benzoate
Sugar pharma grade
Pineapple flavor dry
Water for reconstitution

Quantity
4 gm
5 gm
1 gm
q.s
0.2
56 q.s
q.s
40 ml

Procedure:
Formulation of oral reconstitutable suspension: Powder blend of Amoxycillin trihydrate was prepared
using suspending agents, sweetener, preservative, flavourant, anti-caking agent.
All ingredients were passed through 200# before mixing.
The drug was dry blended with the other ingredients.
Evaluation:
Particle size: Average particle size of the formulation was examined using standard microscopy method
average and standard deviation of 100 particles were estimated
Viscosity: The rheological behavior of the suspension was determined by using Brookfield viscometer.
Sedimention behavior:
1. Redispersibility: By studying number of strokes to redisperse the formed sediment at the end of
7 days of storage of formulation.
2. Sedimentation volume ratio (SVR): Sedimentation behavior of formulations was studied for
sedimentation volume (f) and degree of flocculaton ()
Evaluation data on flow properties of reconstitutable oral suspension:
Parameter
Angle of repose
Bulk density (g/cm)
True density (g/cm)

Value

Evaluation of reconstitutable oral suspension:

Parameter
Avg. particle size (m)
Viscosity (cps)
pH
Redispersibility (No. of
strokes)
Sedimentation volume

Result:

Value

Initial

Final