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@acute Nephrotic Syndrome
@acute Nephrotic Syndrome
@acute Nephrotic Syndrome
PATHOGENESIS
PATHOGENESIS
-hypertension result from fluid retention & renin release from ischemic
kidney.
CAUSES OF NEPHROTIC SYNDROME
1. 1ry glomerular disease
-infection:
Post-streptococcal GN
Non-streptococcal GN (certain pneumococcal &
stapylococcal infections, some viral infections as HCV and
HBV)
2. 2ry to systemic disease
In some cases,
Injury of glomerular capillary wall + injury of pulmonary alveolar
basement membrane wall(due to formation of anti-GBM Ab that cross
react with alveolar basement membrane)
Clinical picture:
Pulmonary haemorrhage with haemoptysis and acute renal failure
(Goodpasture syndrome)
IF: deposits of Ig G/Ig M and complement along capillary wall of kidney
and alveoli wall(Linear pattern)