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  • Normal Liver

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    amthaikratai
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    Cirrhosis is caused by injury to liver cells that activates stellate cells. Activated stellate cells deposit excess extracellular matrix, which leads to fibrosis. As fibrosis progresses, it restricts blood flow through the liver, causing portal hypertension and other complications. The accumulation of collagen in the space of Disse between hepatocytes and sinusoids is a hallmark of cirrhosis.

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    mechanism causing cirrhosis

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    Cirrhosis is caused by injury to liver cells that activates stellate cells. Activated stellate cells deposit excess extracellular matrix, which leads to fibrosis. As fibrosis progresses, it restricts blood flow through the liver, causing portal hypertension and other complications. The accumulation of collagen in the space of Disse between hepatocytes and sinusoids is a hallmark of cirrhosis.

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    31 views2 pages

    Normal Liver

    Uploaded by

    amthaikratai
    Cirrhosis is caused by injury to liver cells that activates stellate cells. Activated stellate cells deposit excess extracellular matrix, which leads to fibrosis. As fibrosis progresses, it restricts blood flow through the liver, causing portal hypertension and other complications. The accumulation of collagen in the space of Disse between hepatocytes and sinusoids is a hallmark of cirrhosis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 2

    Cirrhosis

    Normal liver

     Stellate cells(perisinusoidal space) extracellular


    matrix(collagen type 1,3,4 and glycoprotein,proteoglycan)

    Injury
    Kupffer’s cell,hepatocyteand sinusoidal Portal hypertension
    endothelium

    Produce cytokine, transforming


    growth factor(TGF) Stellate cells have contractile (ที่หดตัวได้ )
    property

    Activate stellate cells Capillarization of sinusoid

    Extracellular matrix Diminution (การลดลง) of


    endothelial fenestrae (ช่อง
    เปิ ดเล็ก)

    fibrosis

    Collagen deposition increases in the


    space of Disse (space between
    hapatocyte and sinusoid)
    Fungal lung infection
    Fungi

    Mucous attack fungi

    hemoptysis
    Mast cells

    Produce histamine Blood vessels dilate

    Difficulty breathing

    Blood permeability

    Dead cells deposit on walls of


    bronchus

    Diapedesis(ออกจากหลอด
    เลือด) of neutrophil

    Neutrophil produces NO (nitric oxide), ROI (reactive Lysis of elastic walls of bronchus
    oxygen intermediate) and proteolytic enzymes

    Dilation of bronchus
    (bronchiectasis)

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