INVESTIGATION OF GENE

MARKERS WHICH LEADS TO

DIABETES MELLITUS THAT HELPS
IN THE DIAGONIS USING
PERSOLALIZED MEDICINE

BACKROUND
The world is facing an epidemic rise in
diabetes mellitus (DM) incidence
Personalized
medicine
combines
bioinformatics
with
genomic,proteomic,metabolomic,
pharmacogenomic (omics) and other
new technologies to explore patho
physiology and to characterize more
precisely an individuals risk for disease,
as well as response to interventions

What is personalised
medicine..?

Fundamental Steps
1. Identification of gene markers and
motifs which are involved in
diabetes mellitus.
2. Using tools obtaining translated
protein and its structure in normal
condition.
3. Again protein and its structure are
predicted for mutated genes.
4. Comparing both the structure for
the variations caused by the

Gene markers associated with

diabetes
CDKAL1, CDKN2A , and CDKN2B that
influence -cell mass.
MTNR1B, TCF7L2, and KCNJ11 that
influence -cell function.
FTO that is associated with obesity.
IRS1 and PPAR- that contribute to
insulin resistance independent of
obesity.

Sample
SIRT1 gene:
It is involved in regulating
metabolism.
A T-C mutation leads to leucine to
proline mutation at residue 107.
This decreases the insulin production
and increase other chemokines level.
For this SIRT1 activators are
developed to blocks the early
disfunction of beta cells.