QUESTION BANK FOR UNIT TEST

Semester: IV
Title of Paper: Medicinal Chemistry
Paper Code: PS04ECHE01

# ANTI NEOPLASTIC AGENTS

1) Write a short note on cancer.
2) Give the synthesis of Melphalan.
3) Define and illustrate various alkylating agents employed in the treatment of cancer.
Discuss the alkylation of guanine in DNA by Methchlorethamine hydrochloride.
4) Write the synthesis of cyclophosphamide and explain its activation by metabolic
transformation.
5) Write a short note on analogue of folate with example of methotraxate.

# CARDIOVASCULAR
1)
2)
3)
4)

Write a short note on Cardiotonic drugs.

What is angina pectoris? Give example of drugs used in it.
Explain -blockers in detail.
Write synthesis and therapeutic uses of the following drugs:
1) Isosorbid dinitrate
2) Erythritol tetranitrate.
5) Explain the term Angina attack.