Griseofulvin

Mechanism of action
Griseofulvin deposits in the stratum corneum layer of skin,
hair, and nails. It inhibits fungal mitosis by blocking assembly
of microtubules. The drug is gradually exfoliated and replaced
by uninfected tissues.
Clinical use
Griseofulvin is used to treat infections of the hair, nails,
and skin.
Adverse effects
The most common side effects are hypersensitive skin
reactions and hives. Although rare, more serious reactions
may occur including angioneurotic edema, gastrointestinal
bleeding, leukopenia, menstrual irregularities, and hepatotoxicity.
The drug is contraindicated in patients with liver disease
and should not be used in pregnant women because of carcinogenic
and teratogenic effects in animal studies. Griseofulvin
may decrease the efficacy of warfarin and oral contraceptives.