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Carotid Duplex

Scan
IMPRESSION:
Circumferential
wall thickening &
significant
stenosis of R
distal CCA & total

Ischemi
a

Common Carotid Artery


occlusion

Turbulent blood flow from


stenotic vessel

R & L Subclavian
Artery Affectation

Joint Pains
Occasional tremors
Diminished brachial Pulse
(Left)
Cold and clammy hands
& feet

Insufficient O2 delivery to
head & brain
(+) Bruit & Thrills
bilateral carotid
area

Transient Ischemic
Dizziness/Lightheadednes
s
Headache
Hypertension
Visual Disturbances

TAKAYASUS
ARTERITIS

PATHOPHYSIOLOGY
Non Modifiable Factors
Race: Asian (Most
common)
Gender: Woman (9:1)
Age: 20 (teens-40s)

Other Risk Factors


Hyperthyroidism
History
Hepatitis A History
Stimulation from
Antigen
Triggering HSP-65 expression to
aortic tissue

Perforin
Acute
Inflammation
Recruiting more
mononuclear cells
(monocytes/phagoc
ytes)
Alpha-beta T-cells
infiltrates

Inducing MICA
(MHC class I
related chain A)

Releasing
NKG2D
Receptors

Inducing more
MICA &
costimulation on
vascular wall

Amplifying
inflammatio
n

Activation of
Dendritic Cell on
Vascular wall

Gamma-delta Tcells & Natural


Killer cells
infiltration
Releasing of pro
inflammatory
cytokines

Cooperates with BCells

Determining Humoral immunity


consisting of anti-endothelial
autoantobodies
Triggering cytotoxicity to
Endothelial Cells

ESR= 19 mm/hr
(Normal value per
age= Age +10/2)

Massive inflammation of Aorta and its


branches
Stenosis of blood
vessels
Anemia (Hgb-10.7
g/dl; hct-32.5%)

Insufficient blood
flow
Cardiovascul
ar

Easy Fatigability
Pale skin
Pale palpebral
conjunctiva

Formation of
Collateral Vessels

Musculoskele
tal

Duplex UTz (0911-13) REMARKS:


Collaterals are
seen along the
Left proximal to
distal CCA, ICA &

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